Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway.

Zhang, Xing; Wang, Sen; Wang, Haixiao; Cao, Jiacheng; Huang, Xiaoxu; Chen, Zheng; Xu, Penghui; Sun, Guangli; Xu, Jianghao; Lv, Jialun; Xu, Zekuan

Zhang, Xing; Wang, Sen; Wang, Haixiao; Cao, Jiacheng; Huang, Xiaoxu; Chen, Zheng; Xu, Penghui; Sun, Guangli; Xu, Jianghao; Lv, Jialun; Xu, Zekuan.

Afiliação

Zhang X; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Wang S; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Wang H; Department of General Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, 223300, Jiangsu, China.
Cao J; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Huang X; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Chen Z; Department of Surgical Oncology, University of Miami, Miami, USA.
Xu P; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Sun G; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Xu J; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Lv J; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China.
Xu Z; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, No.300, Guangzhou Road, Nanjing, Jiangsu Province, China. xuzekuan@njmu.edu.cn.

Mol Cancer ; 18(1): 20, 2019 02 04.

Article em En | MEDLINE | ID: mdl-30717751

Assuntos

Adenocarcinoma/genética; Regulação Neoplásica da Expressão Gênica; MicroRNAs/genética; Proteínas Proto-Oncogênicas c-akt/genética; RNA/genética; Neoplasias Gástricas/genética; Serina-Treonina Quinases TOR/genética; Adenocarcinoma/metabolismo; Adenocarcinoma/mortalidade; Adenocarcinoma/patologia; Idoso; Animais; Linhagem Celular Tumoral; Movimento Celular; Proliferação de Células; Progressão da Doença; Exossomos/metabolismo; Exossomos/patologia; Feminino; Xenoenxertos; Humanos; Metástase Linfática; Masculino; Camundongos; MicroRNAs/metabolismo; Pessoa de Meia-Idade; Estadiamento de Neoplasias; Proteínas Proto-Oncogênicas c-akt/metabolismo; RNA/antagonistas & inibidores; RNA/metabolismo; RNA Circular; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/metabolismo; Transdução de Sinais; Neoplasias Gástricas/metabolismo; Neoplasias Gástricas/mortalidade; Neoplasias Gástricas/patologia; Análise de Sobrevida; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

AKT1; Gastric cancer; Organoid; PDX model; ceRNA; circRNA; miRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / RNA / Adenocarcinoma / Regulação Neoplásica da Expressão Gênica / MicroRNAs / Proteínas Proto-Oncogênicas c-akt / Serina-Treonina Quinases TOR Idioma: En Revista: Mol Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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