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Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity.
Malfacini, Davide; Patt, Julian; Annala, Suvi; Harpsøe, Kasper; Eryilmaz, Funda; Reher, Raphael; Crüsemann, Max; Hanke, Wiebke; Zhang, Hang; Tietze, Daniel; Gloriam, David E; Bräuner-Osborne, Hans; Strømgaard, Kristian; König, Gabriele M; Inoue, Asuka; Gomeza, Jesus; Kostenis, Evi.
Afiliação
  • Malfacini D; From the Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Patt J; From the Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Annala S; From the Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Harpsøe K; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Eryilmaz F; From the Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Reher R; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Crüsemann M; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Hanke W; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Zhang H; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Tietze D; Eduard Zintl Institute of Inorganic and Physical Chemistry, Technische Universität Darmstadt, 64287 Darmstadt, Germany.
  • Gloriam DE; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Bräuner-Osborne H; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • Strømgaard K; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
  • König GM; Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
  • Gomeza J; From the Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany.
  • Kostenis E; From the Molecular, Cellular and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany. Electronic address: kostenis@uni-bonn.de.
J Biol Chem ; 294(15): 5747-5758, 2019 04 12.
Article em En | MEDLINE | ID: mdl-30745359
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Engenharia de Proteínas / Subunidades alfa de Proteínas de Ligação ao GTP / Depsipeptídeos / Inibidores Enzimáticos Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Engenharia de Proteínas / Subunidades alfa de Proteínas de Ligação ao GTP / Depsipeptídeos / Inibidores Enzimáticos Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos