Impaired Cytolytic Activity and Loss of Clonal Neoantigens in Elderly Patients With Lung Adenocarcinoma.

Gong, Zhihua; Jia, Qingzhu; Chen, Junying; Diao, Xinwei; Gao, Jianbao; Wang, Xinxin; Zhu, Bo

Gong, Zhihua; Jia, Qingzhu; Chen, Junying; Diao, Xinwei; Gao, Jianbao; Wang, Xinxin; Zhu, Bo.

Afiliação

Gong Z; Institute of Cancer, Xinqiao Hospital of The Third Military Medical University, Chongqing, China.
Jia Q; Institute of Cancer, Xinqiao Hospital of The Third Military Medical University, Chongqing, China.
Chen J; Institute of Cancer, Xinqiao Hospital of The Third Military Medical University, Chongqing, China.
Diao X; Department of Pathology, Xinqiao Hospital of The Third Military Medical University, Chongqing, China.
Gao J; Institute of Cancer, Xinqiao Hospital of The Third Military Medical University, Chongqing, China.
Wang X; Institute of Cancer, Xinqiao Hospital of The Third Military Medical University, Chongqing, China.
Zhu B; Institute of Cancer, Xinqiao Hospital of The Third Military Medical University, Chongqing, China; Chongqing Key Laboratory of Immunotherapy, Xinqiao Hospital of The Third Military Medical University, Chongqing China. Electronic address: bo.zhu@tmmu.edu.cn.

J Thorac Oncol ; 14(5): 857-866, 2019 05.

Article em En | MEDLINE | ID: mdl-30768970

Assuntos

Adenocarcinoma de Pulmão/genética; Antígenos de Neoplasias/imunologia; Imunoterapia/métodos; Neoplasias Pulmonares/genética; Adenocarcinoma de Pulmão/patologia; Fatores Etários; Idoso; Idoso de 80 Anos ou mais; Estudos de Coortes; Feminino; Humanos; Neoplasias Pulmonares/patologia; Masculino

Palavras-chave

Clonal neoantigen; Immune checkpoint inhibitor; Programmed death ligand 1; Senescence; Tumor mutation burden

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenocarcinoma de Pulmão / Imunoterapia / Neoplasias Pulmonares / Antígenos de Neoplasias Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Thorac Oncol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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