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The Apparent Genetic Anticipation in PMS2-Associated Lynch Syndrome Families Is Explained by Birth-cohort Effect.
Ten Broeke, Sanne W; Rodríguez-Girondo, Mar; Suerink, Manon; Aretz, Stefan; Bernstein, Inge; Capellá, Gabriel; Engel, Christoph; Gomez-Garcia, Encarna B; van Hest, Liselot P; von Knebel Doeberitz, Magnus; Lagerstedt-Robinson, Kristina; Letteboer, Tom G W; Moller, Pal; van Os, Theo A; Pineda, Marta; Rahner, Nils; Olderode-Berends, Maran J W; von Salomé, Jenny; Schackert, Hans K; Spruijt, Liesbeth; Steinke-Lange, Verena; Wagner, Anja; Tops, Carli M J; Nielsen, Maartje.
Afiliação
  • Ten Broeke SW; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. s.w.ten.broeke@umcg.nl.
  • Rodríguez-Girondo M; Department of Medical Statistics, Leiden University Medical Center, Leiden, the Netherlands.
  • Suerink M; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
  • Aretz S; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Bernstein I; Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany.
  • Capellá G; The Danish HNPCC-register, Hvidovre Hospital, Hvidovre, Denmark.
  • Engel C; Department of Surgery, Aalborg University Hospital, Aalborg, Denmark.
  • Gomez-Garcia EB; Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL, ONCOBELL, CIBERONC, L'Hospitalet de Llobregat, Barcelona, Spain.
  • van Hest LP; Leipzig University, Leipzig, Germany.
  • von Knebel Doeberitz M; Maastricht University Medical Center Maastricht, Maastricht, the Netherlands.
  • Lagerstedt-Robinson K; Amsterdam UMC, Vrije Universiteit Amsterdam, Clinical Genetics, Amsterdam, the Netherlands.
  • Letteboer TGW; Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.
  • Moller P; Clinical Cooperation Unit Applied Tumor Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • van Os TA; Department of Molecular Medicine and Surgery, Karolinska Institutet and Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
  • Pineda M; Department of Clinical Genetics, University Medical Center, Utrecht, the Netherlands.
  • Rahner N; Research Group Inherited Cancer Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Norway.
  • Olderode-Berends MJW; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Oslo, Norway.
  • von Salomé J; Center for Hereditary Tumors HELIOS-Klinikum Wuppertal, University of Witten-Herdecke, Wuppertal, Germany.
  • Schackert HK; Department of Clinical Genetics, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
  • Spruijt L; Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL, ONCOBELL, CIBERONC, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Steinke-Lange V; Heinrich-Heine-University Medical Faculty, Institute of Human Genetics, Düsseldorf, Germany.
  • Wagner A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Tops CMJ; Department of Molecular Medicine and Surgery, Karolinska Institutet and Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
  • Nielsen M; Department of Surgical Research, Technische Universität Dresden, Dresden, Germany.
Cancer Epidemiol Biomarkers Prev ; 28(6): 1010-1014, 2019 06.
Article em En | MEDLINE | ID: mdl-30824524
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais Hereditárias sem Polipose / Antecipação Genética / Endonuclease PMS2 de Reparo de Erro de Pareamento / Mutação Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Assunto da revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais Hereditárias sem Polipose / Antecipação Genética / Endonuclease PMS2 de Reparo de Erro de Pareamento / Mutação Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Assunto da revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda País de publicação: Estados Unidos