Chiral ruthenium(II) complex &#916;-[Ru(bpy)<sub>2</sub>(o-FMPIP)] (bpy = bipyridine, o-FMPIP = 2-(2'-trifluoromethyphenyl) imidazo[4,5-f][1,10]phenanthroline) as potential apoptosis inducer via DNA damage.

Bai, Mingjun; Pan, Tao; Yu, Gengnan; Xie, Qiang; Zeng, Zhaolin; Zhang, Yanyang; Zhu, Duo; Mu, Luwen; Qian, Jiesheng; Chang, Boyang; Mei, Wen-Jie; Guan, Shouhai

Chiral ruthenium(II) complex Δ-[Ru(bpy)₂(o-FMPIP)] (bpy = bipyridine, o-FMPIP = 2-(2'-trifluoromethyphenyl) imidazo[4,5-f][1,10]phenanthroline) as potential apoptosis inducer via DNA damage.

Bai, Mingjun; Pan, Tao; Yu, Gengnan; Xie, Qiang; Zeng, Zhaolin; Zhang, Yanyang; Zhu, Duo; Mu, Luwen; Qian, Jiesheng; Chang, Boyang; Mei, Wen-Jie; Guan, Shouhai.

Afiliação

Bai M; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Pan T; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Yu G; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Xie Q; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. Electronic address: doctorxie@126.com.
Zeng Z; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Zhang Y; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Zhu D; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Mu L; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Qian J; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Chang B; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Mei WJ; School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Province Engineering Technology Centre for Molecular Probe and Biomedicine Imaging, Guangzhou 510006, China. Electronic address: wenjiemei@126.com.
Guan S; The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. Electronic address: 1148598268@qq.com.

Eur J Pharmacol ; 853: 49-55, 2019 Jun 15.

Article em En | MEDLINE | ID: mdl-30880177

Assuntos

Apoptose/efeitos dos fármacos; Dano ao DNA; Compostos Organometálicos/química; Compostos Organometálicos/farmacologia; Fenantrolinas/química; Piridinas/química; Rutênio/química; Inibidores da Angiogênese/química; Inibidores da Angiogênese/farmacologia; Inibidores da Angiogênese/toxicidade; Animais; Relação Dose-Resposta a Droga; Células Hep G2; Humanos; Camundongos; Compostos Organometálicos/toxicidade; Estereoisomerismo; Peixe-Zebra

Palavras-chave

Angiogenesis; Apoptosis; Chiral ruthenium(II) complex; DNA Damage

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Fenantrolinas / Piridinas / Rutênio / Dano ao DNA / Apoptose Limite: Animals / Humans Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

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