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Novel 2-Benzoyl-6-(2,3-Dimethoxybenzylidene)-Cyclohexenol Confers Selectivity toward Human MLH1 Defective Cancer Cells through Synthetic Lethality.
Song, Dedrick Soon Seng; Leong, Sze Wei; Ng, Kwok Wen; Abas, Faridah; Shaari, Khozirah; Leong, Chee Onn; Chung, Felicia Fei-Lei; Mai, Chun Wai; Hii, Ling Wei; Tan, Pei Jean; Patel, Vyomesh.
Afiliação
  • Song DSS; 1 Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
  • Leong SW; 2 Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia.
  • Ng KW; 1 Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
  • Abas F; 2 Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia.
  • Shaari K; 3 Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia.
  • Leong CO; 2 Laboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia.
  • Chung FF; 4 Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia.
  • Mai CW; 5 Center for Cancer and Stem Cell Research, International Medical University, Bukit Jalil, Malaysia.
  • Hii LW; 5 Center for Cancer and Stem Cell Research, International Medical University, Bukit Jalil, Malaysia.
  • Tan PJ; 5 Center for Cancer and Stem Cell Research, International Medical University, Bukit Jalil, Malaysia.
  • Patel V; 6 School of Pharmacy, International Medical University, Bukit Jalil, Malaysia.
SLAS Discov ; 24(5): 548-562, 2019 06.
Article em En | MEDLINE | ID: mdl-30897027
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Benzilideno / Neoplasias Colorretais / Estresse Oxidativo / Cicloexenos / Proteína 1 Homóloga a MutL Limite: Humans Idioma: En Revista: SLAS Discov Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Malásia País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Benzilideno / Neoplasias Colorretais / Estresse Oxidativo / Cicloexenos / Proteína 1 Homóloga a MutL Limite: Humans Idioma: En Revista: SLAS Discov Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Malásia País de publicação: Estados Unidos