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Synthesis, and evaluation of in vitro and in vivo anticancer activity of 14-substituted oridonin analogs: A novel and potent cell cycle arrest and apoptosis inducer through the p53-MDM2 pathway.
Shen, Qing-Kun; Deng, Hao; Wang, Shi-Ben; Tian, Yu-Shun; Quan, Zhe-Shan.
Afiliação
  • Shen QK; Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China.
  • Deng H; Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China.
  • Wang SB; School of Pharmacy, Liaocheng University, LiaoCheng, Shandong, 252059, China.
  • Tian YS; Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China. Electronic address: ystian@ybu.edu.cn.
  • Quan ZS; Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China. Electronic address: zsquan@ybu.edu.cn.
Eur J Med Chem ; 173: 15-31, 2019 Jul 01.
Article em En | MEDLINE | ID: mdl-30981113
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Apoptose / Diterpenos do Tipo Caurano / Proteínas Proto-Oncogênicas c-mdm2 / Antineoplásicos Limite: Animals / Female / Humans / Male Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Apoptose / Diterpenos do Tipo Caurano / Proteínas Proto-Oncogênicas c-mdm2 / Antineoplásicos Limite: Animals / Female / Humans / Male Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: França