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Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.
Wang, Zhen; Jiang, Xiangrui; Zhang, Xianglei; Tian, Guanghui; Yang, Rulei; Wu, Jianzhong; Zou, Xiaoli; Liu, Zheng; Yang, Xiaojun; Wu, Chunhui; Shi, Jing; Li, Jianfeng; Suo, Jin; Wang, Yu; Zhang, Rongxia; Xu, Zhijian; Gong, Xudong; He, Yang; Zhu, Weiliang; Aisa, Haji Akber; Jiang, Hualiang; Xu, Yechun; Shen, Jingshan.
Afiliação
  • Wang Z; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Jiang X; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Zhang X; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Tian G; School of Pharmacy , University of Chinese Academy of Sciences , Beijing 100049 , China.
  • Yang R; Vigonvita Life Science Co., Ltd. , Suzhou 215123 , China.
  • Wu J; Vigonvita Life Science Co., Ltd. , Suzhou 215123 , China.
  • Zou X; Vigonvita Life Science Co., Ltd. , Suzhou 215123 , China.
  • Liu Z; Vigonvita Life Science Co., Ltd. , Suzhou 215123 , China.
  • Yang X; Topharman Shanghai Co., Ltd. , Shanghai 201203 , China.
  • Wu C; Topharman Shanghai Co., Ltd. , Shanghai 201203 , China.
  • Shi J; Topharman Shanghai Co., Ltd. , Shanghai 201203 , China.
  • Li J; Topharman Shanghai Co., Ltd. , Shanghai 201203 , China.
  • Suo J; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Wang Y; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Zhang R; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Xu Z; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Gong X; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • He Y; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Zhu W; Key Laboratory of Plant Resources and Chemistry in Arid Regions , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
  • Aisa HA; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Jiang H; CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
  • Xu Y; School of Pharmacy , University of Chinese Academy of Sciences , Beijing 100049 , China.
  • Shen J; Key Laboratory of Plant Resources and Chemistry in Arid Regions , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
J Med Chem ; 62(10): 4979-4990, 2019 05 23.
Article em En | MEDLINE | ID: mdl-31021628
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Inibidores da Fosfodiesterase 5 / Hipertensão Pulmonar Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Inibidores da Fosfodiesterase 5 / Hipertensão Pulmonar Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos