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Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response.
Mandal, Rajarsi; Samstein, Robert M; Lee, Ken-Wing; Havel, Jonathan J; Wang, Hao; Krishna, Chirag; Sabio, Erich Y; Makarov, Vladimir; Kuo, Fengshen; Blecua, Pedro; Ramaswamy, Apoorva T; Durham, Jennifer N; Bartlett, Bjarne; Ma, Xiaoxiao; Srivastava, Raghvendra; Middha, Sumit; Zehir, Ahmet; Hechtman, Jaclyn F; Morris, Luc Gt; Weinhold, Nils; Riaz, Nadeem; Le, Dung T; Diaz, Luis A; Chan, Timothy A.
Afiliação
  • Mandal R; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21287, USA.
  • Samstein RM; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Lee KW; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Havel JJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Wang H; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Krishna C; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Sabio EY; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Makarov V; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Kuo F; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Blecua P; Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Ramaswamy AT; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Durham JN; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Bartlett B; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Ma X; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Srivastava R; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Middha S; Department of Otolaryngology-Head and Neck Surgery, Weill Cornell New York Presbyterian Hospital, New York, NY 10065, USA.
  • Zehir A; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Hechtman JF; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Morris LG; Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Weinhold N; Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Riaz N; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Le DT; Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Diaz LA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Chan TA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Science ; 364(6439): 485-491, 2019 05 03.
Article em En | MEDLINE | ID: mdl-31048490
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Instabilidade de Microssatélites / Reparo de Erro de Pareamento de DNA / Receptor de Morte Celular Programada 1 / Imunoterapia / Neoplasias Limite: Animals Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Instabilidade de Microssatélites / Reparo de Erro de Pareamento de DNA / Receptor de Morte Celular Programada 1 / Imunoterapia / Neoplasias Limite: Animals Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos