Magnesium isoglycyrrhizinate ameliorates radiation-induced pulmonary fibrosis by inhibiting fibroblast differentiation via the p38MAPK/Akt/Nox4 pathway.

Yang, Qunfang; Zhang, Pan; Liu, Tao; Zhang, Xuan; Pan, Xichun; Cen, Yanyan; Liu, Ya; Zhang, Haigang; Chen, Xiaohong

Yang, Qunfang; Zhang, Pan; Liu, Tao; Zhang, Xuan; Pan, Xichun; Cen, Yanyan; Liu, Ya; Zhang, Haigang; Chen, Xiaohong.

Afiliação

Yang Q; Department of Pharmacology, College of Pharmacy and Laboratory Medicine, Army Medical University(Third Military Medical University), Chongqing, 400038, China.
Zhang P; Department of Pharmacy, Army Special Medical Center, Army Medical University(Third Military Medical University), Chongqing, 400042, China.
Liu T; Department of Pharmacology, College of Pharmacy and Laboratory Medicine, Army Medical University(Third Military Medical University), Chongqing, 400038, China.
Zhang X; Department of Pharmacology, College of Pharmacy and Laboratory Medicine, Army Medical University(Third Military Medical University), Chongqing, 400038, China.
Pan X; Department of Pharmacology, College of Pharmacy and Laboratory Medicine, Army Medical University(Third Military Medical University), Chongqing, 400038, China.
Cen Y; Department of Pharmacology, College of Pharmacy and Laboratory Medicine, Army Medical University(Third Military Medical University), Chongqing, 400038, China.
Liu Y; Department of Pharmacology, College of Pharmacy and Laboratory Medicine, Army Medical University(Third Military Medical University), Chongqing, 400038, China.
Zhang H; Department of Pharmacology, College of Pharmacy and Laboratory Medicine, Army Medical University(Third Military Medical University), Chongqing, 400038, China.
Chen X; Department of Pharmacology, College of Pharmacy and Laboratory Medicine, Army Medical University(Third Military Medical University), Chongqing, 400038, China. Electronic address: pharma821@163.com.

Biomed Pharmacother ; 115: 108955, 2019 Jul.

Article em En | MEDLINE | ID: mdl-31075733

Assuntos

Diferenciação Celular/efeitos dos fármacos; Fibroblastos/efeitos dos fármacos; Pulmão/metabolismo; Fibrose Pulmonar/prevenção & controle; Lesões Experimentais por Radiação/prevenção & controle; Saponinas/farmacologia; Triterpenos/farmacologia; Animais; Linhagem Celular; Medicamentos de Ervas Chinesas; Feminino; Fibroblastos/metabolismo; Fibroblastos/efeitos da radiação; Raios gama; Humanos; Pulmão/efeitos dos fármacos; Pulmão/patologia; Camundongos Endogâmicos C57BL; NADPH Oxidase 4/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fibrose Pulmonar/metabolismo; Fibrose Pulmonar/patologia; Lesões Experimentais por Radiação/metabolismo; Lesões Experimentais por Radiação/patologia; Transdução de Sinais/efeitos dos fármacos; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

Fibroblast differentiation; Magnesium isoglycyrrhizinate; Pulmonary fibrosis; Radiation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose Pulmonar / Lesões Experimentais por Radiação / Saponinas / Triterpenos / Diferenciação Celular / Fibroblastos / Pulmão Limite: Animals / Female / Humans Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: França

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