miR-449a inhibits cell proliferation, migration, and inflammation by regulating high-mobility group box protein 1 and forms a mutual inhibition loop with Yin Yang 1 in rheumatoid arthritis fibroblast-like synoviocytes.

Cai, Yongsong; Jiang, Congshan; Zhu, Jialin; Xu, Ke; Ren, Xiaoyu; Xu, Lin; Hu, Peijing; Wang, Bo; Yuan, Qiling; Guo, Yuanxu; Sun, Jian; Xu, Peng; Qiu, Yusheng

Cai, Yongsong; Jiang, Congshan; Zhu, Jialin; Xu, Ke; Ren, Xiaoyu; Xu, Lin; Hu, Peijing; Wang, Bo; Yuan, Qiling; Guo, Yuanxu; Sun, Jian; Xu, Peng; Qiu, Yusheng.

Afiliação

Cai Y; Department of Orthopaedics of the First Affiliated Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Jiang C; Department of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710054, China.
Zhu J; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Xu K; Department of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710054, China.
Ren X; Department of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710054, China.
Xu L; Department of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710054, China.
Hu P; Department of Orthopaedics of the 3201 Hospital, Hanzhong, 723000, China.
Wang B; Department of Cardiovascular Medicine of the Second Affiliated Hospital, Xi'an Medical School, Xi'an, 710038, China.
Yuan Q; Center for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Guo Y; Department of Orthopaedics of the First Affiliated Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Sun J; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Xu P; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Qiu Y; Department of Joint Surgery, Xi'an Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, 710054, China. sousou369@163.com.

Arthritis Res Ther ; 21(1): 134, 2019 06 03.

Article em En | MEDLINE | ID: mdl-31159863

Assuntos

Artrite Reumatoide/genética; Regulação da Expressão Gênica; Proteína HMGB1/genética; Inflamação/genética; MicroRNAs/genética; Sinoviócitos/patologia; Fator de Transcrição YY1/genética; Idoso; Apoptose; Artrite Reumatoide/metabolismo; Artrite Reumatoide/patologia; Western Blotting; Movimento Celular; Proliferação de Células; Células Cultivadas; Ensaio de Imunoadsorção Enzimática; Feminino; Fibroblastos/metabolismo; Fibroblastos/patologia; Proteína HMGB1/biossíntese; Humanos; Inflamação/metabolismo; Inflamação/patologia; Masculino; MicroRNAs/biossíntese; Pessoa de Meia-Idade; RNA/genética; Sinoviócitos/metabolismo; Fator de Transcrição YY1/biossíntese

Palavras-chave

Fibroblast-like synoviocytes; High-mobility group box protein 1; Inflammation; Proliferation; Rheumatoid arthritis; miR-449a

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Regulação da Expressão Gênica / Proteína HMGB1 / MicroRNAs / Fator de Transcrição YY1 / Sinoviócitos / Inflamação Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arthritis Res Ther Assunto da revista: REUMATOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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