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Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures.
Zheng, Jie; Maerz, Winfried; Gergei, Ingrid; Kleber, Marcus; Drechsler, Christiane; Wanner, Christoph; Brandenburg, Vincent; Reppe, Sjur; Gautvik, Kaare M; Medina-Gomez, Carolina; Shevroja, Enisa; Gilly, Arthur; Park, Young-Chan; Dedoussis, George; Zeggini, Eleftheria; Lorentzon, Mattias; Henning, Petra; Lerner, Ulf H; Nilsson, Karin H; Movérare-Skrtic, Sofia; Baird, Denis; Elsworth, Benjamin; Falk, Louise; Groom, Alix; Capellini, Terence D; Grundberg, Elin; Nethander, Maria; Ohlsson, Claes; Davey Smith, George; Tobias, Jonathan H.
Afiliação
  • Zheng J; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Maerz W; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
  • Gergei I; SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany.
  • Kleber M; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Drechsler C; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Wanner C; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Brandenburg V; Department of Cardiology and Nephrology, Rhein-Maas-Klinikum Würselen, Germany.
  • Reppe S; Department of Cardiology and Nephrology, Rhein-Maas-Klinikum Würselen, Germany.
  • Gautvik KM; Department of Cardiology and Nephrology, Rhein-Maas-Klinikum Würselen, Germany.
  • Medina-Gomez C; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
  • Shevroja E; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
  • Gilly A; Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
  • Park YC; Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • Dedoussis G; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  • Zeggini E; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  • Lorentzon M; Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
  • Henning P; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Lerner UH; Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
  • Nilsson KH; University of Cambridge, Cambridge, UK.
  • Movérare-Skrtic S; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
  • Baird D; Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
  • Elsworth B; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Falk L; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Groom A; Geriatric Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Capellini TD; Geriatric Medicine Clinic, Sahlgrenska University Hospital, Mölndal, Sweden.
  • Grundberg E; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Ohlsson C; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Davey Smith G; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
  • Tobias JH; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
J Bone Miner Res ; 34(10): 1824-1836, 2019 10.
Article em En | MEDLINE | ID: mdl-31170332
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Densidade Óssea / Proteínas Adaptadoras de Transdução de Sinal / Fraturas Ósseas / Análise da Randomização Mendeliana Tipo de estudo: Clinical_trials / Prognostic_studies / Systematic_reviews Limite: Aged / Animals / Child / Humans / Middle aged Idioma: En Revista: J Bone Miner Res Assunto da revista: METABOLISMO / ORTOPEDIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Densidade Óssea / Proteínas Adaptadoras de Transdução de Sinal / Fraturas Ósseas / Análise da Randomização Mendeliana Tipo de estudo: Clinical_trials / Prognostic_studies / Systematic_reviews Limite: Aged / Animals / Child / Humans / Middle aged Idioma: En Revista: J Bone Miner Res Assunto da revista: METABOLISMO / ORTOPEDIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos