Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of <i>C. elegans</i> through regulating reproductive signals.

Wan, Qin-Li; Meng, Xiao; Fu, Xiaodie; Chen, Bohui; Yang, Jing; Yang, Hengwen; Zhou, Qinghua

Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals.

Wan, Qin-Li; Meng, Xiao; Fu, Xiaodie; Chen, Bohui; Yang, Jing; Yang, Hengwen; Zhou, Qinghua.

Afiliação

Wan QL; The Center for Precision Medicine of First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou 510632, China.
Meng X; The Center for Precision Medicine of First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou 510632, China.
Fu X; The Center for Precision Medicine of First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou 510632, China.
Chen B; The Center for Precision Medicine of First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou 510632, China.
Yang J; The Center for Precision Medicine of First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou 510632, China.
Yang H; The Center for Precision Medicine of First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou 510632, China.
Zhou Q; The Center for Precision Medicine of First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou 510632, China.

Aging (Albany NY) ; 11(12): 3993-4010, 2019 06 21.

Article em En | MEDLINE | ID: mdl-31232697

Assuntos

Proteínas de Caenorhabditis elegans/metabolismo; Caenorhabditis elegans/fisiologia; Longevidade/fisiologia; Pirimidinas/metabolismo; Animais; Proteínas de Caenorhabditis elegans/genética; Regulação da Expressão Gênica/fisiologia; Interferência de RNA; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Reprodução

Palavras-chave

Caenorhabditis elegans; longevity; pyrimidine metabolism; reproductive signals

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Caenorhabditis elegans / Proteínas de Caenorhabditis elegans / Longevidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Aging (Albany NY) Assunto da revista: GERIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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