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Identification of potent, selective and orally bioavailable phenyl ((R)-3-phenylpyrrolidin-3-yl)sulfone analogues as RORγt inverse agonists.
Lu, Zhonghui; Duan, James J-W; Xiao, Haiyun; Neels, James; Wu, Dauh-Rurng; Weigelt, Carolyn A; Sack, John S; Khan, Javed; Ruzanov, Max; An, Yongmi; Yarde, Melissa; Karmakar, Ananta; Vishwakrishnan, Sureshbabu; Baratam, Venkata; Shankarappa, Harisha; Vanteru, Sridhar; Babu, Venkatesh; Basha, Mushkin; Kumar Gupta, Arun; Kumaravel, Selvakumar; Mathur, Arvind; Zhao, Qihong; Salter-Cid, Luisa M; Carter, Percy H; Murali Dhar, T G.
Afiliação
  • Lu Z; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States. Electronic address: zhonghui.lu@bms.com.
  • Duan JJ; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States. Electronic address: james.duan@bms.com.
  • Xiao H; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Neels J; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Wu DR; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Weigelt CA; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Sack JS; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Khan J; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Ruzanov M; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • An Y; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Yarde M; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Karmakar A; Bristol-Myers Squibb-Biocon Research Center, Bangalore, India.
  • Vishwakrishnan S; Bristol-Myers Squibb-Biocon Research Center, Bangalore, India.
  • Baratam V; Bristol-Myers Squibb-Biocon Research Center, Bangalore, India.
  • Shankarappa H; Bristol-Myers Squibb-Biocon Research Center, Bangalore, India.
  • Vanteru S; Bristol-Myers Squibb-Biocon Research Center, Bangalore, India.
  • Babu V; Bristol-Myers Squibb-Biocon Research Center, Bangalore, India.
  • Basha M; Bristol-Myers Squibb-Biocon Research Center, Bangalore, India.
  • Kumar Gupta A; Bristol-Myers Squibb-Biocon Research Center, Bangalore, India.
  • Kumaravel S; Bristol-Myers Squibb-Biocon Research Center, Bangalore, India.
  • Mathur A; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Zhao Q; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Salter-Cid LM; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Carter PH; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
  • Murali Dhar TG; Research and Development, Bristol-Myers Squibb Company, Princeton, NJ 08543-4000, United States.
Bioorg Med Chem Lett ; 29(16): 2265-2269, 2019 08 15.
Article em En | MEDLINE | ID: mdl-31257087
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinas / Sulfonas / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinas / Sulfonas / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido