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Synthetic lethality of combined AT-101 with idarubicin in acute myeloid leukemia via blockade of DNA repair and activation of intrinsic apoptotic pathway.
Yang, Qianying; Chen, Kai; Zhang, Leisi; Feng, Liying; Fu, Guofeng; Jiang, Shan; Bi, Silei; Lin, Chunjie; Zhou, Yong; Zhao, Haijun; Chen, Xiao Lei; Fu, Guo; Xu, Bing.
Afiliação
  • Yang Q; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
  • Chen K; The First People's Hospital of Foshan (The Affiliated Foshan Hospital of Sun Yat-sen University), Foshan, Guangdong, 528000, China; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
  • Zhang L; Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China.
  • Feng L; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
  • Fu G; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
  • Jiang S; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
  • Bi S; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
  • Lin C; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
  • Zhou Y; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
  • Zhao H; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
  • Chen XL; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
  • Fu G; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China. Electronic address: guofu@xmu.edu.cn.
  • Xu B; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China. Electronic address: xubingzhangjian@126.com.
Cancer Lett ; 461: 31-43, 2019 Oct 01.
Article em En | MEDLINE | ID: mdl-31301319
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Regulação Neoplásica da Expressão Gênica / Apoptose / Reparo do DNA / Mutações Sintéticas Letais Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Lett Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Irlanda
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Regulação Neoplásica da Expressão Gênica / Apoptose / Reparo do DNA / Mutações Sintéticas Letais Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Lett Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Irlanda