First-In-Class Inhibitors Targeting the Interaction between Bacterial RNA Polymerase and Sigma Initiation Factor Affect the Viability and Toxin Release of <i>Streptococcus pneumoniae</i>.

Ye, Jiqing; Chu, Adrian Jun; Lin, Lin; Yang, Xiao; Ma, Cong

First-In-Class Inhibitors Targeting the Interaction between Bacterial RNA Polymerase and Sigma Initiation Factor Affect the Viability and Toxin Release of Streptococcus pneumoniae.

Ye, Jiqing; Chu, Adrian Jun; Lin, Lin; Yang, Xiao; Ma, Cong.

Afiliação

Ye J; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
Chu AJ; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Lin L; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Yang X; Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. xiaoyang@cuhk.edu.hk.
Ma C; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong. cong.ma@polyu.edu.hk.

Molecules ; 24(16)2019 Aug 09.

Article em En | MEDLINE | ID: mdl-31405060

Assuntos

Anti-Infecciosos; Proteínas de Bactérias/antagonistas & inibidores; Toxinas Bacterianas/biossíntese; Fator sigma/antagonistas & inibidores; Streptococcus pneumoniae/metabolismo; Células A549; Anti-Infecciosos/síntese química; Anti-Infecciosos/química; Anti-Infecciosos/farmacologia; Células Hep G2; Humanos; Streptococcus pneumoniae/patogenicidade

Palavras-chave

RNA polymerase; antimicrobial discovery; inhibitor; sigma factor; transcription

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator sigma / Streptococcus pneumoniae / Proteínas de Bactérias / Toxinas Bacterianas / Anti-Infecciosos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Hong Kong País de publicação: Suíça

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