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Outbreak of aplastic crises in sickle cell anaemia associated with parvovirus-like agent
Lancet ; 2(8247): 595-7, Sept. 19, 1981.
Article em En | MedCarib | ID: med-14386
Biblioteca responsável: JM3.1
Localização: JM3.1; R31.L3
ABSTRACT
Since 1952, 112 childen with sickle cell anaemia (SCA) in Jamaica have had an aplastic crisis. Outbreaks occurred in 1956, 1960, 1965-67, 1971-73, and 1979-80. Most cases occurred in children under 10 years of age, and an aplastic crisis in a patient over the age of 15 years is rare. There were 38 cases in 1970-80 and stored serum specimens from 28 of these were available for virus studies. Evidence for infection with a parvovirus-like agent was found in 24 of these 28 cases. Viral antigen was detected in 2 patients, both of whom demonstated seroconversion. Serconversion during 1980 was detected in a further 7, increasing amounts of antibody during the convalescent period were found in 5, antibody was found in 2 of 4 patients from whom only an acute phase specimen was available and the remaining 10 were antibody positive in the only convalescent phase sample available for testing. Antibody was found in 4 of 94 controls with the SS genotype (in retrospect 2 of these may have had an aplastic crisis) and in 17 percent of 48 controls with a normal haemoglobin (AA) genotype. The results accord with the possibility that the parvovirus-like agent is the principal cause of aplastic crisis in SCA (Summary)
Assuntos
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Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Parvoviridae / Viroses / Surtos de Doenças / Anemia Falciforme Tipo de estudo: Risk_factors_studies Limite: Child / Child, preschool / Humans / Infant País/Região como assunto: Caribe ingles / Jamaica Idioma: En Revista: Lancet Ano de publicação: 1981 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Parvoviridae / Viroses / Surtos de Doenças / Anemia Falciforme Tipo de estudo: Risk_factors_studies Limite: Child / Child, preschool / Humans / Infant País/Região como assunto: Caribe ingles / Jamaica Idioma: En Revista: Lancet Ano de publicação: 1981 Tipo de documento: Article