Influenza vaccination and major adverse vascular events in high-risk patients
Circulation
; 126: 278-286, 2012. tab
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1062024
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
BackgroundWe sought to determine the association between influenza vaccination and major adverse vascular events because the association remains uncertain.Methods and ResultsA total of 31 546 participants were enrolled from 40 countries. Eligibility included age 55 years and known vascular disease. The primary outcome was a composite of death resulting from cardiovascular causes, myocardial infarction, or stroke during 4 influenza seasons (20032007). Influenza vaccination was associated with a lower risk of the outcome during 3 influenza seasons (defined using World Health Organization FluNet reports) 2004to 2005 (adjusted odds ratio [OR], 0.62; 95% confidence interval [CI], 0.500.77), 2005 to 2006 (adjusted OR, 0.69; 95% CI, 0.53 0.91), and 2006 to 2007 (adjusted OR, 0.52; 95% CI, 0.42 0.65), the same years that circulating influenza matched the vaccine antigen. In 2003 to 2004, there was an incomplete match between circulating influenza and the vaccine antigen, and there was no association between influenza vaccination and the outcome (adjusted OR, 0.96; 95% CI, 0.731.27). However, tests of potential biases in the analyses revealed associations between influenza vaccination and outcome during noninfluenza seasons except 2003 to 2004. The summary ORs in the influenza season (OR, 0.65; 95% CI, 0.580.74]) and noninfluenza season (OR, 0.66; 95% CI, 0.57 0.76) were almost identical. The reduction in risk of noncardiovascular death associated with the influenza vaccine ranged from 73% to 79%.ConclusionAlthough initial analyses suggest that influenza vaccination was associated with reduced risk of majoradverse vascular events during influenza seasons when the influenza vaccine matched the circulating virus, sensitivity analyses revealed that risk of bias remained. A randomized trial is needed to definitively address this question.
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Coleções:
Bases de dados nacionais
/
Brasil
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.8 Atingir a cobertura universal de saúde
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Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
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Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
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Doença Cardiovascular
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Doença Cerebrovascular
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Doença Isquêmica do Coração
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Vacinação
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Acidente Vascular Cerebral
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Prevenção de Doenças
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Infecções
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Infarto do Miocárdio
Tipo de estudo:
Ensaio clínico controlado
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Estudo de etiologia
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Fatores de risco
Idioma:
Inglês
Revista:
Circulation
Ano de publicação:
2012
Tipo de documento:
Artigo
Instituição/País de afiliação:
Cardiovascular Medicine, John Radcliffe Hospital/GB
/
Chinese Academy of Medical Sciences/CN
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Dante Pazzanese Institute of Cardiology/BR
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Hypertension Unit, UZ Gasthuisberg/BE
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McMaster University/CA
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University of Guadalajara/MX