Intravascular imaging comparison of two metallic limus-eluting stents abluminally coated with biodegradable polymers: IVUS and OCT results of the DESTINY trial
Int J Cardiovasc Imaging
; 33(2): 161-168, 2017.
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1063485
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
We sought to compare, by means of IVUS and OCT imaging, the performance of a novel sirolimus-eluting drug-eluting stent (DES) with biodegradable polymer (Inspiron) to the Biomatrix DES. From the DESTINY trial, a total of 70 randomized patients (21) were enrolled in the IVUS substudy (Inspiron, n = 46; Biomatrix n = 20) while 25 patients were evaluated with OCT (Inspiron, n = 19; Biomatrix n = 06) at 9-month follow-up. The main endpoints were % of neointimal tissue obstruction (IVUS) and neointimal stut coverage (OCT) at 9 months. Patients treated with both DES had very little NIH formation at 9 months either by IVUS (% of NIH obstruction of 4.9 ± 4.1 % with Inspiron vs. 2.7 ± 2.9 % with Biomatrix, p = 0.03) or by OCT (neointimal thickness of 144.2 ± 72.5 µm Inspiron vs. 115.0 ± 53.9 µm with Biomatrix, p = 0.45). Regarding OCT strut-level assessment, again both devices showed excellent 9-month performance, with high rates of strut coverage (99.49 ± 1.01 % with Inspiron vs. 97.62 ± 2.21 % with Biomatrix, p < 0.001) and very rare malapposition (0.29 ± 1.06 % with Inspiron vs. 0.53 ± 0.82 % with Biomatrix, p = 0.44). Patients with any uncovered struts were more frequently identified in the Biomatrix group (9.78 ± 7.13 vs. 2.29 ± 3.91 %, p < 0.001)...
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Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Sirolimo
/
Stents Farmacológicos
Tipo de estudo:
Ensaio clínico controlado
Idioma:
Inglês
Revista:
Int J Cardiovasc Imaging
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Cardiovascular Research Center/BR
/
Hospital Encore/BR
/
Hospital do Servidor Público Estadual-IAMSPE/BR
/
Instituto Dante Pazzanese de Cardiologia/BR
/
University of São Paulo Medical School/BR