Detalhe da pesquisa
1.
A roadmap towards a human-centric safety assessment of advanced therapy medicinal products.
Regul Toxicol Pharmacol;
150: 105631, 2024 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38648873
2.
Exploring Greater Flexibility for Chronic Toxicity Study Designs to Support Human Safety Assessment While Balancing 3Rs Considerations.
Int J Toxicol;
: 10915818241255885, 2024 May 31.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38822557
3.
Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.
Regul Toxicol Pharmacol;
138: 105329, 2023 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36592682
4.
The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.
Regul Toxicol Pharmacol;
138: 105339, 2023 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36649820
5.
Applicability of organ-on-chip systems in toxicology and pharmacology.
Crit Rev Toxicol;
51(6): 540-554, 2021 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34463591
6.
Animal-free applications in the development of cell-based therapies.
Br J Clin Pharmacol;
87(6): 2425-2427, 2021 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32935350
7.
Translatability of preclinical to early clinical tolerable and pharmacologically active dose ranges for central nervous system active drugs.
Transl Psychiatry;
13(1): 74, 2023 03 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36859342
8.
The ability of animal studies to detect serious post marketing adverse events is limited.
Regul Toxicol Pharmacol;
64(3): 345-9, 2012 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22982732
9.
Tradition, not science, is the basis of animal model selection in translational and applied research.
ALTEX;
38(1): 49-62, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32591838
10.
Sex Proportionality in Pre-clinical and Clinical Trials: An Evaluation of 22 Marketing Authorization Application Dossiers Submitted to the European Medicines Agency.
Front Med (Lausanne);
8: 643028, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33791329
11.
Levelling the Translational Gap for Animal to Human Efficacy Data.
Animals (Basel);
10(7)2020 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32679706
12.
Comparison of drug efficacy in two animal models of type 2 diabetes: A systematic review and meta-analysis.
Eur J Pharmacol;
879: 173153, 2020 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32360835
13.
Baseline imbalances and clinical outcomes of atypical antipsychotics in dementia: A meta-epidemiological study of randomized trials.
Int J Methods Psychiatr Res;
28(1): e1757, 2019 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30515916
14.
Correction: A standardised framework to identify optimal animal models for efficacy assessment in drug development.
PLoS One;
14(7): e0220325, 2019.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31329650
15.
Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer's disease.
Eur J Pharmacol;
859: 172524, 2019 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31291566
16.
A standardised framework to identify optimal animal models for efficacy assessment in drug development.
PLoS One;
14(6): e0218014, 2019.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31194784
17.
Role of histamine in short- and long-term effects of methamphetamine on the developing mouse brain.
J Neurochem;
107(4): 976-86, 2008 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18786166
18.
An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity.
J Pharmacol Exp Ther;
323(3): 888-98, 2007 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17855474
19.
Impairments in spatial memory retention of GFAP-apoE4 female mice.
Behav Brain Res;
176(2): 372-5, 2007 Jan 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17126420
20.
Mouse behavioural analysis in systems biology.
Biochem J;
389(Pt 3): 593-610, 2005 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16035954