RESUMEN
PURPOSE: Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its a-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders. METHODS: This is a randomized, crossover, open-labeled, two- center study. Forty patients (20 open-angle glaucoma patients and 20 healthy subjects) were treated with ibopamine 2% eye drops and phenylephrine 10% eye drops. RESULTS: Ibopamine induced a significant increase in IOP only in glaucomatous eyes (p<0.001) without a significant hypertensive effect in normal eyes. Ibopamine and phenylephrine showed a similar mydriatic activity but ibopamine was able to induce an hypertensive effect only in glaucomatous eyes. CONCLUSIONS: The results confirm the use of ibopamine as provocative test in detection of hydrodynamic disorders.(Eur J Ophthalmol 2004; 14: #-13).
RESUMEN
PURPOSE: Ibopamine is a prodrug of N-methyldopamine that has a non-cycloplegic mydriatic action due to its alpha-adrenergic properties and is able to induce, when topically given, a transient increase of intraocular pressure (IOP) in eyes with hydrodynamic disorders. METHODS: This is a randomized, crossover, open-labeled, two- center study. Forty patients (20 open-angle glaucoma patients and 20 healthy subjects) were treated with ibopamine 2% eye drops and phenylephrine 10% eye drops. RESULTS: Ibopamine induced a significant increase in IOP only in glaucomatous eyes (p<0.001) without a significant hypertensive effect in normal eyes. Ibopamine and phenylephrine showed a similar mydriatic activity but ibopamine was able to induce an hypertensive effect only in glaucomatous eyes. CONCLUSIONS: The results confirm the use of ibopamine as provocative test in detection of hydrodynamic disorders.
Asunto(s)
Desoxiepinefrina/análogos & derivados , Desoxiepinefrina/farmacología , Glaucoma de Ángulo Abierto/complicaciones , Presión Intraocular/efectos de los fármacos , Midriáticos/farmacología , Pupila/efectos de los fármacos , Administración Tópica , Anciano , Antihipertensivos/uso terapéutico , Estudios Cruzados , Desoxiepinefrina/administración & dosificación , Femenino , Glaucoma de Ángulo Abierto/diagnóstico , Glaucoma de Ángulo Abierto/tratamiento farmacológico , Humanos , Masculino , Persona de Mediana Edad , Midriáticos/administración & dosificación , Soluciones Oftálmicas/administración & dosificación , Soluciones Oftálmicas/farmacología , Fenilefrina/administración & dosificación , Fenilefrina/uso terapéutico , Tonometría OcularRESUMEN
The authors evaluated the effect of the replacement of beta-blockers with brimonidine drops in patients taking beta-blockers only or with dorzolamide, having IOP > 20 mmHg. The study was divided into two sections: one group treated with brimonidine b.i.d. (23 patients) and the other group treated with brimonidine + dorzolamide b.i.d. (17 patients). The effect of the substitution showed after 90 days of treatment with a reduction of 8.59 +/- 1.2 mmHg (P < 0.001) in the first group and 6.1 +/- 1.7 mmHg (P < 0.001) in the second group. Three patients in the first group and four patients in the second group presented minor adverse effects which did not justify discontinuation of treatment. Brimonidine was effective treatment as a substitute for beta-blockers only when associated with dorzolamide.
Asunto(s)
Agonistas alfa-Adrenérgicos/uso terapéutico , Antagonistas Adrenérgicos beta/uso terapéutico , Glaucoma de Ángulo Abierto/tratamiento farmacológico , Presión Intraocular/efectos de los fármacos , Quinoxalinas/uso terapéutico , Anciano , Anciano de 80 o más Años , Tartrato de Brimonidina , Enfermedad Crónica , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Insuficiencia del TratamientoAsunto(s)
Catarata/terapia , Glaucoma de Ángulo Abierto/cirugía , Facoemulsificación , Esclerostomía , Trabeculectomía , Anciano , Catarata/complicaciones , Glaucoma de Ángulo Abierto/complicaciones , Humanos , Presión Intraocular , Implantación de Lentes Intraoculares , Estudios Prospectivos , Resultado del Tratamiento , Agudeza VisualAsunto(s)
Desoxiepinefrina/análogos & derivados , Agonistas de Dopamina , Síndrome de Exfoliación/complicaciones , Glaucoma/diagnóstico , Midriáticos , Humor Acuoso/efectos de los fármacos , Humor Acuoso/metabolismo , Glaucoma/etiología , Humanos , Presión Intraocular/efectos de los fármacos , Hipertensión Ocular/diagnóstico , Hipertensión Ocular/etiologíaAsunto(s)
Catarata/congénito , Glaucoma/congénito , Adulto , Catarata/diagnóstico por imagen , Cuerpo Ciliar/cirugía , Estudios de Seguimiento , Glaucoma/diagnóstico por imagen , Glaucoma/cirugía , Gonioscopía , Humanos , Presión Intraocular , Coagulación con Láser , Masculino , Desprendimiento de Retina/cirugía , Curvatura de la Esclerótica , UltrasonografíaAsunto(s)
Desoxiepinefrina/análogos & derivados , Desoxiepinefrina/administración & dosificación , Midriáticos/administración & dosificación , Refracción Ocular/fisiología , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Presión Intraocular/efectos de los fármacos , Masculino , Persona de Mediana Edad , Soluciones Oftálmicas , Estudios ProspectivosRESUMEN
Trans-scleral cyclophotocoagulation is an efficacious method in neovascular glaucoma (NVG) treatment. We have used it with krypton laser on 12 eyes of 12 patients affected by NVG with algetic symptoms. Six months after treatment, intraocular pressure was down enough for the pain to disappear. Executional simplicity and the possibility of modulating the intensity of the treatment are grounds for the encouragement of the technique's use in NVG.
