1.
J Med Chem
; 65(16): 11388-11403, 2022 08 25.
Artículo
en Inglés
| MEDLINE
| ID: mdl-35972896
RESUMEN
Filarial diseases, including lymphatic filariasis and onchocerciasis, are considered among the most devastating of all tropical diseases, affecting about 145 million people worldwide. Efforts to control and eliminate onchocerciasis are impeded by a lack of effective treatments that target the adult filarial stage. Herein, we describe the discovery of a series of substituted di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as novel macrofilaricides for the treatment of human filarial infections.
Asunto(s)
Filariasis Linfática , Oncocercosis , Adulto , Aminas , Humanos
2.
Angew Chem Int Ed Engl
; 41(22): 4233-6, 2002 Nov 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12434348