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Epigenomics ; 12(19): 1689-1706, 2020 10.
Artículo en Inglés | MEDLINE | ID: mdl-33125285

RESUMEN

Aim: To evaluate CpG methylation of long interspersed nuclear elements 1 (LINE-1) and human endogenous retrovirus K (HERV-K) retroelements as potential prognostic biomarkers in cutaneous melanoma. Materials & methods: Methylation of HERV-K and LINE-1 retroelements was assessed in resected melanoma tissues from 82 patients ranging in age from 14 to 88 years. In addition, nevi from eight patients were included for comparison with nonmalignant melanocytic lesions. Results: Methylation levels were lower in melanomas than in nevi. HERV-K and LINE-1 methylation were decreased in melanoma patients with clinical parameters associated with adverse prognosis, while they were independent of age and gender. Hypomethylation of HERV-K (but not LINE-1) was an independent predictor of reduced disease-free survival. Conclusion: HERV-K hypomethylation can be a potential independent biomarker of melanoma recurrence.


Asunto(s)
Metilación de ADN , Elementos de Nucleótido Esparcido Largo , Melanoma/genética , Retroelementos , Neoplasias Cutáneas/genética , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Islas de CpG , Supervivencia sin Enfermedad , Retrovirus Endógenos , Femenino , Humanos , Masculino , Melanoma/patología , Persona de Mediana Edad , Recurrencia Local de Neoplasia/genética , Estadificación de Neoplasias , Nevo/genética , Pronóstico , Neoplasias Cutáneas/patología , Secuencias Repetidas Terminales , Adulto Joven
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