[Fatal Toxic Epidermal Necrolysis Induced by Diclofenac Re-Administration in the Teaching Hospital of Bouaké (Côte d'Ivoire)]. / Syndrome de Lyell d'évolution fatale suite à la réadministration de diclofénac, au CHU de Bouaké (Côte d'Ivoire).

Lyell's syndrome or toxic epidermal necrolysis is an acute and severe cutaneous adverse drug reaction with a significant morbidity and mortality. It is a very rare condition but a vital emergency with a poor prognosis. The diagnosis is clinical and confirmed by a cutaneous biopsy showing a necrosis of the epidermis. It can be due to many drugs including non-steroidal anti-inflammatory drugs. We report a case of fatal Lyell's syndrome after oral re-administration of diclofenac in a patient with a previous history of diclofenac-related Stevens-Johnson syndrome, four years back.

Nous rapportons un cas de syndrome de Lyell mortel après réadministration orale de diclofénac chez un patient ayant des antécédents de syndrome de Stevens-Johnson lié au diclofénac quatre ans auparavant.

Investigation and management of suspected urachal anomalies in children.

Urachal anomalies occur infrequently, but may be associated with morbidity, particularly when the diagnosis has been delayed. We retrospectively reviewed our institution's experience over a 10-year and 7-month period in the investigation and management of suspected urachal anomalies. There were 25 children between November 1995 and June 2006, who presented with a suspected urachal anomaly. The mean age was 12 months (range 3 days to 13 years); 14 were male. Presentations included granulomatous polyp (16), umbilical discharge (4), umbilical sepsis (2) and abdominal pain (2). One case was diagnosed incidentally during a renal ultrasound scan (US). The main investigative tool was US (10), followed by micturating cystourethrogram (2). Of the 25 children, 12 had a patent urachus confirmed by subsequent further imaging or surgery. Our review suggests that whilst clinical examination remains important in the management of a child presenting with a possible urachal pathology, in 36% of the cases the correct diagnosis was only made with further radiological imaging or at operation. Surgical excision was effective with no morbidity or mortality.