1.
Bioorg Med Chem Lett
; 26(8): 2072-6, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26948541
RESUMO
A series of aminonaphthoquinone-sulfonylamidine conjugates were synthesized via a copper-catalyzed three-component reaction of N-propargyl aminonaphthoquinone, sulfonyl azides and various amines. Majority of the compounds exhibited promising antiproliferative potential when evaluated against a panel of four cancer cell lines. Docking experiments of representative compounds indicated that the conjugates can occupy the ATP-binding pocket of topoisomerase-II enzyme.