Assuntos
Janus Quinase 2/genética , Mutação Puntual , Policitemia Vera/genética , Adulto , Humanos , MasculinoRESUMO
A 56-year-old farmer who had been suffering from exogenous allergic alveolitis developed, after a long prodromal period of illness, a granulocyte-rich pericardial effusion and bilateral pleural effusions in which Actinomyces aggregates were identified. Despite intensive treatment with clindamycin, erythromycin and tetracycline (he was allergic to penicillin) he died in septic shock.
Assuntos
Actinomicose/diagnóstico , Doenças Torácicas/diagnóstico , Actinomicose/etiologia , Actinomicose/patologia , Doenças dos Trabalhadores Agrícolas/complicações , Doenças dos Trabalhadores Agrícolas/patologia , Alveolite Alérgica Extrínseca/complicações , Alveolite Alérgica Extrínseca/patologia , Empiema/diagnóstico , Empiema/etiologia , Empiema/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Derrame Pericárdico/diagnóstico , Derrame Pericárdico/etiologia , Derrame Pericárdico/patologia , Choque Séptico/etiologia , Choque Séptico/patologia , Doenças Torácicas/etiologia , Doenças Torácicas/patologiaRESUMO
In a case of oral overdose of cyclosporin we measured plasma concentrations by radioimmunoassay and high pressure liquid chromatography. We observed unchanged pharmacokinetic parameters after the overdose indicating normal renal and hepatic function. Laboratory findings showed no renal or hepatic damage. As toxic symptoms, only emesis and a short, mild drowsiness were noted.
Assuntos
Transplante de Medula Óssea , Ciclosporinas/intoxicação , Erros de Medicação , Criança , Cromatografia Líquida de Alta Pressão , Ciclosporinas/sangue , Ciclosporinas/farmacocinética , Feminino , Humanos , RadioimunoensaioRESUMO
We report on the first Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) characterized by a rearrangement within the 5' part of the bcr gene on chromosome 22, but outside the restricted breakpoint cluster region. In situ hybridization studies revealed a translocation of the c-abl oncogene to the Ph chromosome and Northern blot analysis identified a chimeric 8 kb bcr/abl RNA transcript in leukemic cells. These data suggest that 1. less bcr coding sequences than previously assumed may be essential for the putative transforming activity of the rearranged bcr/abl gene and 2. the bcr probes currently used for diagnostic purposes could miss Ph-positive CML cases.
Assuntos
Leucemia Mieloide/genética , Oncogenes , Cromossomo Filadélfia , Adulto , Humanos , MasculinoRESUMO
We report on a 39-year-old male patient suffering from seropositive rheumatoid arthritis who developed severe colitis during oral gold (Auranofin) therapy. So far, two further cases of colitis during oral, and 28 cases of enterocolitis during parenteral chrysotherapy have been described. The pathomechanism has not been identified. Symptomatic therapy was applied, under which our patient recovered from intestinal discomfort in a few weeks. In differential diagnosis gold induced colitis has to be distinguished both from loose stools occurring during oral gold therapy, most probably caused by an inhibition of NA+K+ ATPase, and from colitis induced by concomitant application of nonsteroidal anti-inflammatory drugs.