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The incidence of coronary artery aneurysm is between 1.4% and 4.9% based on autopsy or angiographic series. Mycotic coronary arteries aneurysms are very rare and represent less than 3% of all coronary aneurysms. We report the case of a patient who presented with multiple coronary mycotic aneurysms.
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Background: Previous data have shown that sex-related differences exist in aortic arch surgery, with female patients experiencing worse outcomes. Over time, as surgical techniques and strategies have improved, these improvements have benefitted female patients. Using a multicenter national aortic registry from the Canadian Thoracic Aortic Collaborative (CTAC), we aimed to determine the relationship between sex and outcomes following aortic arch repair and to examine how these have changed over time. Methods: The multicenter prospective CTAC database of all aortic procedures performed under circulatory arrest from participating centers across Canada (n=9) was used. Patients were included who underwent elective or urgent/emergency arch reconstruction under circulatory arrest from 2002 to 2021. The primary composite endpoint was defined as the occurrence of one of the following endpoints: in-hospital mortality, stroke, dialysis-dependent renal failure, deep sternal wound infection, reoperation, or prolonged ventilation of >40 hours. Secondary endpoints included in-hospital mortality, in-hospital stroke, and a modified version of the Society of Thoracic Surgeons-defined composite endpoint for mortality and major morbidity (MMOM). Results: A total of 2,592 patients who underwent aortic arch repair between 2002 and 2021 (31.4% female and 68.6% male patients). Operative mortality decreased through the study period for female patients. No change in operative mortality was observed in male patients or following elective repair. The composite endpoint improved for female patients over time in both elective and urgent surgery, while for male patients, rates improved for elective surgery and remained stable for urgent. Ultimately, female sex was not an independent predictor of adverse outcomes following aortic arch repair. Conclusions: Our results are congruent with existing data and are highly encouraging. It shows that multilevel improvements in our approach to aortic arch surgery have helped to serve female patients who were previously disadvantaged.
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Patients with new-onset left bundle branch block (LBBB) after transcatheter aortic valve implantation (TAVI) are at risk of developing delayed high-degree atrioventricular block. Management of new-onset LBBB post-TAVI remains controversial. In the Comparison of a Clinical Monitoring Strategy Versus Electrophysiology-Guided Algorithmic Approach in Patients With a New LBBB After TAVI (COME-TAVI) trial, consenting patients with new-onset LBBB that persists on day 2 after TAVI, meeting exclusion/inclusion criteria, are randomized to an electrophysiological study (EPS)-guided approach or 30-day electrocardiographic monitoring. In the EPS-guided approach, patients with a His to ventricle (HV) interval ≥ 65 ms undergo permanent pacemaker implantation. Patients randomized to noninvasive monitoring receive a wearable continuous electrocardiographic recording and transmitting device for 30 days. Follow-up will be performed at 3, 6, and 12 months. The primary endpoint is a composite outcome designed to capture net clinical benefit. The endpoint incorporates major consequences of both strategies in patients with new-onset LBBB after TAVI, as follows: (i) sudden cardiac death; (ii) syncope; (iii) atrioventricular conduction disorder requiring a pacemaker (for a class I or IIa indication); and (iv) complications related to the pacemaker or EPS. The trial incorporates a Bayesian design with a noninformative prior, outcome-adaptive randomization (initially 1:1), and 2 prespecified interim analyses once 25% and 50% of the anticipated number of primary endpoints are reached. The trial is event-driven, with an anticipated upper limit of 452 patients required to reach 77 primary outcome events over 12 months of follow-up. In summary, the aim of this Bayesian multicentre randomized trial is to compare 2 management strategies in patients with new-onset LBBB post-TAVI-an EPS-guided approach vs noninvasive 30-day monitoring. Trial registration number: NCT03303612.
Les patients chez qui un bloc de branche gauche (BBG) est récemment apparu à la suite de l'implantation valvulaire aortique par cathéter (IVAC) présentent un risque de bloc auriculoventriculaire de haut degré tardif. La prise en charge d'un BBG récemment apparu après une IVAC demeure controversée. Dans le cadre de l'essai COME-TAVI (Comparison of a ClinicalMonitoring Strategy VersusElectrophysiology-Guided Algorithmic Approach in Patients With a New LBBB AfterTAVI, ou comparaison d'une stratégie de surveillance clinique, par rapport à une approche guidée par étude électrophysiologique et fondée sur un algorithme, chez des patients présentant un BBG d'apparition récente à la suite d'une IVAC), des patients qui présentent un BBG d'apparition récente persistant le 2e jour après une IVAC, qui répondent aux critères d'admissibilité et qui ont donné leur consentement sont répartis aléatoirement pour être suivis à l'aide d'une approche guidée par une étude électrophysiologique (EEP) ou faire l'objet d'une surveillance électrocardiographique d'une durée de 30 jours. Un stimulateur cardiaque est implanté chez les patients du groupe de l'EEP dont l'intervalle HV (temps de conduction dans le tronc du faisceau de His jusqu'aux ventricules) est ≥ 65 ms. Les patients du groupe de surveillance non invasive reçoivent un dispositif portable d'enregistrement et de transmission continue de données électrocardiographiques pour une période de 30 jours. Le suivi sera réalisé aux 3e, 6e et 12e mois. Le critère d'évaluation principal est un paramètre composite conçu afin de saisir le bienfait clinique net. Il comprend les conséquences majeures des deux stratégies chez les patients présentant un BBG d'apparition récente après une IVAC, comme suit : (i) mort subite d'origine cardiaque; (ii) syncope; (iii) trouble de la conduction auriculoventriculaire nécessitant la pose d'un stimulateur cardiaque (pour une indication de classe I ou IIa); et (iv) complications relatives au stimulateur cardiaque ou à l'EEP. L'essai intègre une conception bayésienne avec une répartition aléatoire (dans un rapport initial de 1:1) antérieure non informative adaptée aux résultats et deux analyses intermédiaires définies au préalable lorsque 25 % et 50 % du nombre anticipé des critères d'évaluation principaux seront atteints. L'essai est axé sur les événements, et la limite supérieure anticipée pour atteindre 77 événements relatifs aux critères d'évaluation principaux sur 12 mois de suivi est de 452 patients. En résumé, l'objectif de cet essai bayésien multicentrique à répartition aléatoire est de comparer deux stratégies de prise en charge de patients présentant un BBG d'apparition récente après une IVAC, soit une approche guidée par une EEP, par rapport à une surveillance non invasive de 30 jours. Trial registration number: NCT03303612.
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Management of aortic arch pathologies remains challenging. Open total arch replacements have been associated with significant morbidity and mortality owing to the need for cardiopulmonary bypass and circulatory arrest. On the other hand, aortic arch-branched stent grafts are not widely available. In this context, hybrid techniques combining open arch debranching with endovascular graft placement have been identified as an attractive option in select patients. However, there still is a paucity of literature on their application and outcomes. A case is presented of an elderly frail patient diagnosed with a pseudoaneurysm of the aortic arch and who was successfully treated by an off-pump arch debranching followed by endovascular arch repair. This case highlights (i) the feasibility of hybrid debranching techniques, (ii) their technical challenges, and (iii) the need for long-term follow-up data.
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Aneurisma da Aorta Torácica , Implante de Prótese Vascular , Procedimentos Endovasculares , Humanos , Idoso , Aneurisma da Aorta Torácica/cirurgia , Procedimentos Endovasculares/métodos , Aorta Torácica/cirurgia , Prótese Vascular , Implante de Prótese Vascular/métodos , Stents , Resultado do TratamentoRESUMO
OBJECTIVE: This study evaluated the frequency and clinical impact of thromboembolic complications after frozen elephant trunk aortic arch repair using the Thoraflex device (Terumo Aortic). METHODS: A total of 128 consecutive patients (mean age 67.9 ± 13.7 years, 31.0% female) underwent frozen elephant trunk aortic arch repair using the Thoraflex device between September 2014 and May 2021 in 4 Canadian centers. Patient baseline characteristics, intraoperative details, and frozen elephant trunk thromboembolic complications were collected retrospectively and analyzed. RESULTS: Fifteen patients (11.7%) had thrombus visualized within the frozen elephant trunk stent graft on imaging (n = 8; 53.3%) or had a thromboembolic event (n = 9; 60.0%) before hospital discharge. Sites of embolism were mesenteric (n = 8; 88.9%), renal (n = 4; 44.4%), and iliofemoral (n = 1; 11.1%). Patients who experienced thromboembolic complications were more likely to have a history of autoimmune disease (n = 3; 20.0% vs n = 2; 1.8%; P = .01) and implantation of a longer frozen elephant trunk stent graft (150 mm vs 100 mm) (n = 13; 86.7% vs n = 45; 39.8%; P < .001). All patients with thromboembolic complications received therapeutic anticoagulation, and a smaller proportion required an open surgical (n = 5; 33.3%) or an endovascular (n = 2; 13.3%) intervention. Radiographic resolution of thromboembolic complications was observed in 86.7% of patients (n = 13). In-hospital mortality occurred in 1 patient, stroke occurred in 1 patient, and transient spinal cord injury occurred in 1 patient. CONCLUSIONS: Thromboembolic complications occur more often than previously recognized after frozen elephant trunk aortic arch repair using the Thoraflex device and are associated with increased rates of surgical and endovascular reintervention. Prevention and management of these complications require further study.
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A pericardial cyst is one of the rare causes of mediastinal masses. Most of the cases are secondary to congenital incomplete fusion of the pericardial sac. More than two-thirds of the cases are present in the right cardiophrenic angle, and the left cardiophrenic angle is the second most common location. In our study, we illustrated an incidental finding of the pericardial cyst in a patient who presented with nonspecific symptoms and was found to have a left-sided cardiophrenic pericardial cyst, which is only found in about 20% of the cases. A CT scan and echocardiogram confirmed the diagnosis of a 4.39-centimeter cyst with no signs of complications like tamponade or pericarditis. As the patient's symptoms resolved, outpatient follow-up with serial echocardiogram was advised. Through this report, we aim to raise awareness of the importance of further investigation for nonspecific symptoms like atypical chest tightness and differentiating simple pericardial cysts from other pericardial lesions. Based on the symptoms, size, and compression effect of the cyst, management may vary from serial echocardiogram to aspiration or surgical resection.
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False lumen patency is a poor prognostic factor for favorable aortic remodeling in patients with chronic aortic dissection. Several endovascular techniques are available to obliterate the false lumen; however, they are not always successful. We present the case of a 55-year old male with a chronic type B dissection and a large descending thoracic aortic aneurysm with rapid growth, up to 90 mm, despite attempted control of the false lumen with several endovascular devices (thoracic aortic stent graft, Amplatzer device, glue and candy plug). Successful aneurysmal open repair was achieved by removing these devices during the procedure. This case demonstrates the technical challenges of explanting an aortic stent graft and multiple other devices during distal aortic repair.
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Aneurisma da Aorta Torácica , Implante de Prótese Vascular , Procedimentos Endovasculares , Aorta Torácica/cirurgia , Aneurisma da Aorta Torácica/cirurgia , Prótese Vascular , Implante de Prótese Vascular/métodos , Procedimentos Endovasculares/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Stents , Resultado do TratamentoRESUMO
BACKGROUND: To explore evolving surgical techniques and outcomes for aortic arch surgery. METHODS: A total of 2435 consecutive patients underwent aortic arch repair with hypothermic circulatory arrest between 2008 and 2018 in 12 institutions across Canada. Trends in patient characteristics, surgical techniques, and in-hospital outcomes, including major morbidity or mortality, were examined. RESULTS: From 2008 to 2018, the age of patients (62.3 ± 13.2 years) and the proportion of women (30.2%) undergoing arch surgery did not change significantly. Aortic diameters at operation decreased (2008: 58 ± 13 mm; 2018: 53 ± 11 mm; P < 0.01). Surgeons performed more valve-sparing root replacements (2008: 0%; 2018: 15%; P < 0.001) and fewer Bentall procedures (2008: 27%; 2018: 20%; P < 0.01). Total arch replacement rates were similar (Pâ¯=â¯0.18); however, elephant trunk (2008: 9.5%; 2018: 19%; P < 0.001) and frozen elephant trunk (2008: 3.1%; 2018: 15%; P < 0.001) repair rates have increased. Over time, higher nadir temperatures (2008: 18 [17-21]°C; 2018: 25 [23-28]°C; P < 0.001), and more frequent antegrade cerebral perfusion (2008: 61%; 2018: 83%; P < 0.001) were used. For elective cases, in-hospital mortality rates declined (2008: 6.8%; 2018: 1.2%; Pâ¯=â¯< 0.01), as did major morbidity or mortality (2008: 24%; 2018: 13%; P < 0.001) and transfusion rates (2008: 61%; 2018: 41%; P < 0.001), but stroke rates remained constant (2008: 6.8%; 2018: 5.3%; Pâ¯=â¯0.12). Outcomes remained the same over time for urgent or emergent cases. CONCLUSIONS: Outcomes have improved over the past decade in Canada for elective aortic arch surgery, in the context of operating on smaller aortas, and more frequent use of moderate hypothermia and antegrade cerebral perfusion. Further research is needed to improve stroke rates and outcomes in the emergency setting.
INTRODUCTION: Examiner l'évolution des techniques chirurgicales et les résultats de l'intervention chirurgicale de l'arc aortique. MÉTHODES: Un total de 2 435 patients consécutifs ont subi une réparation de l'arc aortique en arrêt circulatoire en hypothermie entre 2008 et 2018 dans 12 établissements du Canada. Nous avons examiné les tendances en ce qui concerne les caractéristiques des patients, les techniques chirurgicales et les résultats cliniques intrahospitaliers, y compris les principales causes de morbidité ou de mortalité. RÉSULTATS: De 2008 à 2018, l'âge des patients (62,3 ± 13,2 ans) et la proportion de femmes (30,2 %) subissant l'intervention chirurgicale de l'arc n'a pas montré de changement significatif. Les diamètres aortiques à l'opération ont diminué (2008 : 58 ± 13 mm; 2018 : 53 ± 11 mm; P < 0,01). Les chirurgiens ont réalisé un plus grand nombre de remplacements de la racine aortique sans remplacement de la valve (2008 : 0 %; 2018 : 15 %; P < 0,001) et un moins grand nombre d'opérations de Bentall (2008 : 27 %; 2018 : 20 %; P < 0,01). Les taux totaux de remplacements de l'arc étaient similaires (P = 0,18). Toutefois, les taux de réparation avec la technique de la trompe d'éléphant; (2008 : 9,5 %; 2018 : 19 %; P < 0,001) et de la trompe d'éléphant congelée (2008 : 3,1 %; 2018 : 15 %; P < 0,001) ont augmenté. Avec le temps, des nadirs supérieurs de température (2008 : 18 [17-21]°C; 2018 : 25 [23-28]°C; P < 0,001) et des perfusions cérébrales antérogrades plus fréquentes (2008 : 61 %; 2018 : 83 %; P < 0,001) ont été utilisés. Pour les cas non urgents, les taux de mortalité intrahospitalière (2008 : 6,8 %; 2018 : 1,2 %; P = < 0,01) et les taux de morbidité grave et de mortalité (2008 : 24 %; 2018 : 13 %; P < 0,001) et de transfusion (2008 : 61 %; 2018 : 41 %; P < 0,001) ont décru, mais les taux d'accidents vasculaires cérébraux (2008 : 6,8 %; 2018 : 5,3 %; P = 0,12) sont demeurés constants. Les résultats cliniques sont demeurés identiques au fil du temps pour les cas urgents ou les nouveaux cas. CONCLUSIONS: Au Canada, les résultats de l'intervention chirurgicale non urgente de l'arc aortique se sont améliorés au cours de la dernière décennie dans le contexte de l'opération d'aortes plus petites et de l'utilisation plus fréquente de l'hypothermie modérée et de la perfusion cérébrale antérograde. D'autres recherches sont nécessaires pour améliorer les taux d'accidents vasculaires cérébraux et les résultats cliniques dans le cadre d'interventions urgentes.
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OBJECTIVE: There is a need to develop a realistic model of open saphenous vein harvesting for simulation training and assessment. The purpose of this study was to develop a novel simulated model of this procedure and to examine its viability by examining participants' performance and feedback on this model. METHODS: A total of 14 participants (cardiac surgeons, residents, students) conducted open saphenous vein harvesting on a portable, noncommercial, simulated vein model (complete with artificial vein, subcutaneous tissue, and skin) within an operating room. Surgical assistance was provided by a cardiac resident. Participants provided feedback through questionnaires and interviews. Technical performance was rated by 2 blinded raters using a global rating scale for operative technical skills. RESULTS: Quantitative analyses demonstrated that participants considered the model to be realistic and useful. Analyses of performance ratings indicated that the model could be used as a reliable indicator of skill level, given that raters were able to use performance scores to discriminate participants according to their level of experience at a high level of accuracy. Participants with a higher level of experience performed significantly better than those with a lower level of experience. Qualitative analyses revealed the model was considered to be most beneficial to learn procedural steps of vein harvesting and basic surgical skills. CONCLUSIONS: Results provide support for the technical fidelity of this model and its ability to identify skill level for assessment of vein harvesting. Future work should examine transfer of surgical skills from simulator to clinical practice to assess its viability for training.
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OBJECTIVE: Postpartum hysterectomy is an uncommon yet serious obstetric procedure associated with maternal morbidity and mortality. The objectives of our study were to assess the incidence of and indications for PH and to identify predictors of massive hemorrhage and coagulopathy. METHODS: We conducted a retrospective cohort study on all cases of PH performed at the Jewish General Hospital, McGill University, between 1992 and 2011. Data were collected from individual patient charts and logistics regression models were used to evaluate predictors of adverse events. RESULTS: Over a 20-year study period, there were 76 938 live births and 67 postpartum hysterectomies for an overall incidence of 0.87/1000. Although overall PH rates increased over time predominantly because of increasing rates of planned PH for placental abnormalities, there was a decrease in unplanned emergency postpartum hysterectomies. The main indications for PH were abnormal placentation (64.2%) and postpartum hemorrhage (26.9%). In adjusted analysis, the risk of requiring massive blood transfusion was increased when PH was performed after vaginal delivery or Caesarean section (OR 102.1; 95% CI 4.22 to 2468) and in association with postpartum hemorrhage (OR 9.1; 95% CI 1.3 to 64.3). The risk of massive hemorrhage was lower if occlusive balloons were placed antenatally in the uterine arteries (OR 0.13; 95% CI 0.03 to 0.68) and if PH was performed by a dedicated experienced surgeon (OR 0.23; 95% CI 0.06 to 0.86). CONCLUSION: Although overall rates of PH are increasing, antenatal recognition of placental pathologies have resulted in fewer postpartum hysterectomies being done as emergencies. The use of occlusive balloons in the uterine arteries and having the procedure performed by a dedicated surgeon skilled in performing postpartum hysterectomy can reduce overall serious morbidity.
Objectif : L'hystérectomie postpartum (HP) est une intervention obstétricale peu courante, mais grave, qui est associée à de la morbidité et à la mortalité chez la mère. Les objectifs de notre étude étaient d'évaluer l'incidence de l'HP et ses indications, et d'identifier les facteurs prédictifs de l'hémorragie massive et de la coagulopathie. Méthodes : Nous avons mené une étude de cohorte rétrospective qui portait sur tous les cas d'HP menés à l'Hôpital général juif de l'Université McGill entre 1992 et 2011. Les données ont été tirées des dossiers des patientes ciblées et nous avons utilisé des modèles de régression logistique pour évaluer les facteurs prédictifs d'événements indésirables. Résultats : Au cours de la période d'étude de 20 ans, nous avons constaté 76 938 naissances vivantes et 67 cas d'hystérectomie postpartum, l'incidence globale de cette dernière étant donc de 0,87/1 000. Bien que les taux globaux d'HP aient connu une hausse avec le temps (principalement en raison de la hausse des taux d'HP planifiée en raison de la présence d'anomalies placentaires), nous avons constaté une baisse du nombre de cas d'hystérectomie postpartum d'urgence (non planifiées). Les principales indications de l'HP ont été la présence d'une placentation anormale (64,2 %) et celle d'une hémorragie postpartum (26,9 %). Dans le cadre d'une analyse corrigée, nous avons constaté que le risque de nécessiter une transfusion massive de sang connaissait une hausse lorsqu'une HP était menée à la suite d'un accouchement vaginal ou d'une césarienne (RC, 102,1; IC à 95 %, 4,22 - 2 468), ainsi qu'en association avec la présence d'une hémorragie postpartum (RC, 9,1; IC à 95 %, 1,3 - 64,3). Le risque d'hémorragie massive était moindre lorsque des ballonnets occlusifs étaient placés, avant la naissance, dans les artères utérines (RC, 0,13; IC à 95 %, 0,03 0,68) et lorsque l'HP était menée par un chirurgien d'expérience spécialisé (RC, 0,23; IC à 95 %, 0,06 - 0,86). Conclusion : Bien que les taux globaux d'HP soient en hausse, la capacité de reconnaître la présence de pathologies placentaires pendant la période prénatale s'est soldée en un nombre moindre de cas d'hystérectomie postpartum de nature urgente. L'utilisation de ballonnets occlusifs dans les artères utérines et le fait d'avoir recours à un chirurgien d'expérience spécialisé dans la tenue d'interventions d'hystérectomie postpartum peuvent atténuer le taux global de morbidité grave.