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1.
J Am Chem Soc ; 2024 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-39440841

RESUMO

Molecular transformation behavior within a mechanically interlocked system is often assisted by chemical manipulation, such as the inclusion of guest molecules, variation in the solution concentration, or swapping of solvents. We present in this report the synthesis of ruthenium metal and π-conjugated pyrene-based (2 + 2)2 catenated rectangles. Additionally, we discuss the structural conversion of these catenated rectangles into monorectangles through adjustments in concentration and solvent composition. In the presence of a methanol solution, a transformation into monorectangles was observed as the concentration declined. However, interestingly, in the presence of a nitromethane solution, an alteration in conformation to monorectangles was noted by just standing at room temperature for a few hours without any chemical manipulation. Furthermore, theoretical calculations were studied to provide insights into the formation of catenated structures over other potential ring-in-ring or Borromean-ring-type structures. The computational study with the GFN2-xTB method combined with density functional theory (DFT) calculations showed that the lower binding energy within the rectangles favors a catenated structure over other potential ring-in-ring or Borromean-ring-type structures. This work represents a new example of an intertwined structure that self-assembles into a catenated ring rather than a ring-in-ring or Borromean ring and transforms into a monorectangle in nitromethane without the use of any template, alteration in solution concentration, or exchange of solvents, but simply by standing at room temperature.

2.
J Int Adv Otol ; 20(4): 372-374, 2024 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-39162066

RESUMO

Hemangioma is a common vascular neoplasm that arises in the head and neck regions but is rare in the petrous bone. We report the first case of a solitary cavernous hemangioma in the mastoid antrum. A 68-year-old woman visited our hospital with a complaint of tinnitus without any other symptoms. Tinnitus of the right ear occurred especially when the patient yawned or swallowed. Both tympanic membranes appeared normal on otoscopic examination. On pure-tone audiometry, mild hearing loss up to 25 dB was detected in the right ear. Temporal bone computed tomography revealed a 7.0 mm × 4.5 mm × 5 mm, solitary soft tissue mass in the aditus ad antrum. Excisional biopsy was performed under general anesthesia through the canal wall as in a mastoidectomy. The mass was completely removed without any bleeding or ossicular chain damage. The mass was confirmed as a cavernous hemangioma. During follow-up, the patient's tinnitus and right low-tone hearing loss improved. No solitary hemangioma of the mastoid antrum has been reported previously. Surgical excision of the lesion appears to be proper treatment to achieve pathologic confirmation along with resolution of symptoms.


Assuntos
Hemangioma Cavernoso , Processo Mastoide , Zumbido , Humanos , Feminino , Idoso , Hemangioma Cavernoso/cirurgia , Hemangioma Cavernoso/patologia , Hemangioma Cavernoso/diagnóstico por imagem , Hemangioma Cavernoso/diagnóstico , Processo Mastoide/cirurgia , Processo Mastoide/patologia , Zumbido/etiologia , Mastoidectomia/métodos , Tomografia Computadorizada por Raios X , Audiometria de Tons Puros/métodos , Neoplasias Cranianas/cirurgia , Neoplasias Cranianas/patologia , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/diagnóstico por imagem , Resultado do Tratamento
3.
Nanomaterials (Basel) ; 14(5)2024 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-38470806

RESUMO

Exploring the utilization of ion exchange membranes (IEMs) in salinity gradient energy harvesting, a technique that capitalizes on the salinity difference between seawater and freshwater to generate electricity, this study focuses on optimizing PVDF to Nafion ratios to create ultra-thin membranes. Specifically, our investigation aligns with applications such as reverse electrodialysis (RED), where IEMs facilitate selective ion transport across salinity gradients. We demonstrate that membranes with reduced Nafion content, particularly the 50:50 PVDF:Nafion blend, retain high permselectivity comparable to those with higher Nafion content. This challenges traditional understandings of membrane design, highlighting a balance between thinness and durability for energy efficiency. Voltage-current analyses reveal that, despite lower conductivity, the 50:50 blend shows superior short-circuit current density under salinity gradient conditions. This is attributed to effective ion diffusion facilitated by the blend's unique microstructure. These findings suggest that blended membranes are not only cost-effective but also exhibit enhanced performance for energy harvesting, making them promising candidates for sustainable energy solutions. Furthermore, these findings will pave the way for advances in membrane technology, offering new insights into the design and application of ion exchange membranes in renewable energy.

4.
Adv Sci (Weinh) ; 11(11): e2309016, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38233207

RESUMO

A novel class of o-carboranyl luminophores, 2CB-BuDABNA (1) and 3CB-BuDABNA (2) is reported, in which o-carborane moieties are incorporated at the periphery of the B,N-doped multi-resonance thermally activated delayed fluorescence (MR-TADF) core. Both compounds maintain the inherent local emission characteristics of their MR-emitting core, exhibiting intense MR-TADF with high photoluminescence quantum yields in toluene and rigid states. In contrast, the presence of the dark lowest-energy charge transfer state, induced by cage rotation in THF, is suggested to be responsible for emission quenching in a polar solvent. Despite the different arrangement of the cage on the DABNA core, both 1 and 2 show red-shifted emissions compared to the parent compound BuDABNA (3). By utilizing 1 as the emitter, high-efficiency blue organic light-emitting diodes (OLEDs) are achieved with a remarkable maximum external quantum efficiency of 25%, representing the highest reported efficiency for OLEDs employing an o-carboranyl luminophore as the emitter.

5.
Plant Direct ; 7(12): e552, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38116182

RESUMO

Arabidopsis flowering is dependent on interactions between a component of the florigens FLOWERING LOCUS T (FT) and the basic leucine zipper (bZIP) transcription factor FD. These proteins form a complex that activates the genes required for flowering competence and integrates environmental cues, such as photoperiod and temperature. However, it remains largely unknown how FT and FD are regulated at the protein level. To address this, we created FT transgenic plants that express the N-terminal FLAG-tagged FT fusion protein under the control of its own promoter in ft mutant backgrounds. FT transgenic plants complemented the delayed flowering of the ft mutant and exhibited similar FT expression patterns to wild-type Col-0 plants in response to changes in photoperiod and temperature. Similarly, we generated FD transgenic plants in fd mutant backgrounds that express the N-terminal MYC-tagged FD fusion protein under the FD promoter, rescuing the late flowering phenotypes in the fd mutant. Using these transgenic plants, we investigated how temperature regulates the expression of FT and FD proteins. Temperature-dependent changes in FT and FD protein levels are primarily regulated at the transcript level, but protein-level temperature effects have also been observed to some extent. In addition, our examination of the expression patterns of FT and FD in different tissues revealed that similar to the spatial expression pattern of FT, FD mRNA was expressed in both the leaf and shoot apex, but FD protein was only detected in the apex, suggesting a regulatory mechanism that restricts FD protein expression in the leaf during the vegetative growth phase. These transgenic plants provided a valuable platform for investigating the role of the FT-FD module in flowering time regulation.

6.
BMC Musculoskelet Disord ; 24(1): 973, 2023 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-38102571

RESUMO

BACKGROUND: The upper normoglycemic range has been proposed as a risk factor for degenerative rotator cuff tendon tear (RCT), and insulin resistance has been suggested as a risk factor for tendinopathy. However, no research has established their association with degenerative RCT in the general population. This study aimed to determine whether fasting glucose levels and insulin resistance are risk factors for degenerative RCT in the normoglycemic population and identify the risk range for fasting glucose. METHODS: This study included 418 normoglycemic participants from a rural cohort. Participants completed questionnaires, physical exams, blood tests, and MRI evaluations of both shoulders. Insulin resistance was assessed using a triglyceride/high-density-lipoprotein (TG/HDL) ≥ 3.5. Logistic regression analysis was used to determine the association between fasting glucose level, TG/HDL ≥ 3.5, and other factors and degenerative RCT. The study calculated the areas under the receiver operating characteristic curve (AUC) to determine the more appropriate predicting value between the scale and categorical values of fasting glucose levels, and compared the AUCs using the DeLong method. RESULTS: In the multivariable analyses, both scale and categorical values of fasting glucose levels, and TG/HDL ≥ 3.5 were significantly associated with degenerative RCT. Fasting glucose levels ≥ 90.5 mg/dL (OR: 3.87, 95% CI: 2.10-7.06) in scale value and 90-99 mg/dL (OR: 4.13, 95% CI: 2.87-8.12) in categorical value were significantly associated with degenerative RCT (P < .001). The AUC of the scale value of fasting glucose levels ≥ 90.5 mg/dL was 0.68. The AUC of the categorical value of fasting glucose levels of 90-99 mg/dL was 0.70. Because of the significantly larger AUC of the categorical value of fasting glucose levels of 90-99 mg/dL, those fasting glucose levels were determined to be independently associated with degenerative RCT (P < .001). CONCLUSIONS: High fasting glucose levels within the normal range may link to increase insulin resistance and risk of degenerative RCT. Normoglycemic levels of 90-99 mg/dL and insulin resistance may be risk factors for degenerative RCT. LEVEL OF EVIDENCE: Level III, prognostic study.


Assuntos
Resistência à Insulina , Lesões do Manguito Rotador , Humanos , Lesões do Manguito Rotador/diagnóstico por imagem , Lesões do Manguito Rotador/complicações , Ombro , Jejum , Glucose
7.
J Adv Res ; 2023 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-37926145

RESUMO

INTRODUCTION: Ambient temperature-induced hypocotyl elongation in Arabidopsis seedlings is sensed by the epidermis-localized phytochrome B (phyB) and transduced into auxin biosynthesis via a basic helix-loop-helix transcription factor, phytochrome-interacting factor 4 (PIF4). Once synthesized, auxin travels down from the cotyledons to the hypocotyl, triggering hypocotyl cell elongation. Thus, the phyB-PIF4 module involved in thermosensing and signal transduction is a potential genetic target for engineering warm temperature-insensitive plants. OBJECTIVES: This study aims to manipulate warm temperature-induced elongation of plants at the post-translational level using phyB variants with dark reversion, the expression of which is subjected to heat stress. METHODS: The thermosensitive growth response of Arabidopsis was manipulated by expressing the single amino acid substitution variant of phyB (phyB[G515E]), which exhibited a lower dark reversion rate than wild-type phyB. Other variants with slow (phyB[G564E]) or rapid (phyB[S584F]) dark reversion or light insensitivity (phyB[G767R]) were also included in this study for comparison. Warming-induced transient expression of phyB variants was achieved using heat shock-inducible promoters. Arabidopsis PHYB[G515E] and PHYB[G564E] were also constitutively expressed in rice in an attempt to manipulate the heat sensitivity of a monocotyledonous plant species. RESULTS: At an elevated temperature, Arabidopsis seedlings transiently expressing PHYB[G515E] under the control of a heat shock-inducible promoter exhibited shorter hypocotyls than those expressing PHYB and other PHYB variant genes. This warm temperature-insensitive growth was related to the lowered PIF4 and auxin responses. In addition, transgenic rice seedlings expressing Arabidopsis PHYB[G515E] and PHYB[G564E] showed warm temperature-insensitive shoot growth. CONCLUSION: Transient expression of phyB variants with altered dark reversion rates could serve as an effective optogenetic technique for manipulating PIF4-auxin-mediated thermomorphogenic responses in plants.

8.
Drug Test Anal ; 15(11-12): 1439-1448, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37667448

RESUMO

Due to athletes' misuse of recombinant human growth hormone (rhGH) for performance improvement, the World Anti-Doping Agency has designated rhGH as a prohibited substance. This study focuses on the development and improvement of a simple and fast rhGH detection method using a fluorescence-incorporated antibody sensor "Quenchbody (Q-body)" that activates upon antigen binding. Camelid-derived nanobodies were used to produce stable Q-bodies that withstand high temperatures and pH levels. Notably, pituitary human growth hormone (phGH) comprises two major isoforms, namely 22 and 20 kDa GH, which exist in a specific ratio, and the rhGH variant shares the same sequence as the 22 kDa GH isoform. Therefore, we aimed to discriminate rhGH abuse by analyzing its specific isoform ratio. Two nanobodies, NbPit (recognizing phGH) and NbRec (preferentially recognizing 22 kDa rhGH), were used to develop the Q-bodies. Nanobody production in Escherichia coli involved the utilization of a vector containing 6xHis-tag, and Q-bodies were obtained using a maleimide-thiol reaction between the N-terminal of the cysteine tag and a fluorescent dye. The addition of tryptophan residue through antibody engineering resulted in increased fluorescence intensity (FI) (from 2.58-fold to 3.04-fold). The limit of detection (LOD) was determined using a fluorescence response, with TAMRA-labeled NbRec successfully detecting 6.38 ng/ml of 22 kDa rhGH while unable to detect 20 kDa GH. However, ATTO520-labeled NbPit detected 7.00 ng/ml of 20 kDa GH and 2.20 ng/ml 22 kDa rhGH. Q-bodies successfully detected changes in the GH concentration ratio from 10 to 40 ng/ml in human serum within 10 min without requiring specialized equipment and kits. Overall, these findings have potential applications in the field of anti-doping measures and can contribute to improved monitoring and enforcement of rhGH misuse, ultimately enhancing fairness and integrity in competitive sports.


Assuntos
Hormônio do Crescimento Humano , Anticorpos de Domínio Único , Humanos , Hormônio do Crescimento , Proteínas Recombinantes , Isoformas de Proteínas
9.
Sci Data ; 10(1): 642, 2023 09 20.
Artigo em Inglês | MEDLINE | ID: mdl-37730712

RESUMO

The blue bat star, a highly adaptive species in the East Sea of Korea, has displayed remarkable success in adapting to recent climate change. The genetic mechanisms behind this success were not well-understood, prompting our report on the first chromosome-level assembly of the Patiria genus. We assembled the genome using Nanopore and Illumina sequences, yielding a total length of 615 Mb and a scaffold N50 of 24,204,423 bp. Hi-C analysis allowed us to anchor the scaffold sequences onto 22 pseudochromosomes. K-mer based analysis revealed 5.16% heterozygosity rate of the genome, higher than any previously reported echinoderm species. Our transposable element analysis exposed a substantial number of genome-wide retrotransposons and DNA transposons. These results offer valuable resources for understanding the evolutionary mechanisms behind P. pectinifera's successful adaptation in fluctuating environments.


Assuntos
Evolução Biológica , Genoma , Estrelas-do-Mar , Mudança Climática , Elementos de DNA Transponíveis , Retroelementos
10.
Trends Plant Sci ; 28(10): 1098-1100, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-37574427

RESUMO

In 1998, Bill Gray and colleagues showed that warm temperatures trigger arabidopsis hypocotyl elongation in an auxin-dependent manner. This laid the foundation for a vibrant research discipline. With several active members of the 'thermomorphogenesis' community, we here reflect on 25 years of elevated ambient temperature research and look to the future.


Assuntos
Proteínas de Arabidopsis , Arabidopsis , Proteínas de Arabidopsis/metabolismo , Regulação da Expressão Gênica de Plantas , Arabidopsis/genética , Arabidopsis/metabolismo , Temperatura , Hipocótilo/metabolismo , Ácidos Indolacéticos
11.
Sci Data ; 10(1): 560, 2023 08 23.
Artigo em Inglês | MEDLINE | ID: mdl-37612339

RESUMO

This study presents the first chromosome-level genome assembly of Hanwoo, an indigenous Korean breed of Bos taurus taurus. This is the first genome assembly of Asian taurus breed. Also, we constructed a pangenome graph of 14 B. taurus genome assemblies. The contig N50 was over 55 Mb, the scaffold N50 was over 89 Mb and a genome completeness of 95.8%, as estimated by BUSCO using the mammalian set, indicated a high-quality assembly. 48.7% of the genome comprised various repetitive elements, including DNAs, tandem repeats, long interspersed nuclear elements, and simple repeats. A total of 27,314 protein-coding genes were identified, including 25,302 proteins with inferred gene names and 2,012 unknown proteins. The pangenome graph of 14 B. taurus autosomes revealed 528.47 Mb non-reference regions in total and 61.87 Mb Hanwoo-specific regions. Our Hanwoo assembly and pangenome graph provide valuable resources for studying B. taurus populations.


Assuntos
Povo Asiático , Bovinos , Genoma , Sequências de Repetição em Tandem , Animais , Bovinos/genética , Humanos , Cromossomos/genética , República da Coreia
12.
Angew Chem Int Ed Engl ; 62(32): e202306879, 2023 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-37321976

RESUMO

Designing multi-resonance (MR) emitters that can simultaneously achieve narrowband emission and suppressed intermolecular interactions is challenging for realizing high color purity and stable blue organic light-emitting diodes (OLEDs). Herein, a sterically shielded yet extremely rigid emitter based on a triptycene-fused B,N core (Tp-DABNA) is proposed to address the issue. Tp-DABNA exhibits intense deep blue emissions with a narrow full width at half maximum (FWHM) and a high horizontal transition dipole ratio, superior to the well-known bulky emitter, t-DABNA. The rigid MR skeleton of Tp-DABNA suppresses structural relaxation in the excited state, with reduced contributions from the medium- and high-frequency vibrational modes to spectral broadening. The hyperfluorescence (HF) film composed of a sensitizer and Tp-DABNA shows reduced Dexter energy transfer compared to those of t-DABNA and DABNA-1. Notably, deep blue TADF-OLEDs with the Tp-DABNA emitter display higher external quantum efficiencies (EQEmax =24.8 %) and narrower FWHMs (≤26 nm) than t-DABNA-based OLEDs (EQEmax =19.8 %). The HF-OLEDs based on the Tp-DABNA emitter further demonstrate improved performance with an EQEmax of 28.7 % and mitigated efficiency roll-offs.

13.
Trends Plant Sci ; 28(8): 924-940, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37045740

RESUMO

Plants constantly face fluctuating ambient temperatures and must adapt to survive under stressful conditions. Temperature affects many aspects of plant growth and development through a complex network of transcriptional responses. Although temperature sensing is a crucial primary step in initiating transcriptional responses via Ca2+ and/or reactive oxygen species signaling, an understanding of how plants perceive temperature has remained elusive. However, recent studies have yielded breakthroughs in our understanding of temperature sensors and thermosensation mechanisms. We review recent findings on potential temperature sensors and emerging thermosensation mechanisms, including biomolecular condensate formation through phase separation in plants. We also compare the temperature perception mechanisms of plants with those of other organisms to provide insights into understanding temperature sensing by plants.


Assuntos
Desenvolvimento Vegetal , Plantas , Temperatura , Plantas/genética , Transdução de Sinais , Percepção
14.
Plant Signal Behav ; 18(1): 2193913, 2023 12 31.
Artigo em Inglês | MEDLINE | ID: mdl-36961244

RESUMO

Ambient temperature is one of the major environmental factors affecting flowering. As the temperature rises, most plants, including Arabidopsis, flower more rapidly. In addition, phenotypic variability in flowering time tends to increase at warm ambient temperatures. The increased variability of flowering time at warm temperatures prevents accurate flowering time measurements, particularly when evaluating the flowering time of Arabidopsis plants under short-day conditions in order to restrict the photoperiodic effect. Here, we propose a simple method for reducing the variability of flowering time at warm temperatures. Instead of growing plants at different temperatures from germination, the strategy of first vegetative growth at cool temperatures and then shifting to warm temperatures allows plants to respond more stably and robustly to warm temperatures. Consistent with flowering time measurements, plants grown under the modified growth condition exhibited higher levels of FLOWERING LOCUS T (FT) gene expression than plants grown exclusively at warm temperatures. This approach enables more precise thermo-response studies of flowering time control in Arabidopsis.


Assuntos
Proteínas de Arabidopsis , Arabidopsis , Arabidopsis/fisiologia , Fatores de Transcrição/metabolismo , Temperatura , Proteínas de Ligação a DNA/metabolismo , Proteínas de Arabidopsis/genética , Proteínas de Arabidopsis/metabolismo , Plantas Geneticamente Modificadas/metabolismo , Flores/fisiologia , Fotoperíodo , Regulação da Expressão Gênica de Plantas
15.
J Med Chem ; 66(7): 5154-5170, 2023 04 13.
Artigo em Inglês | MEDLINE | ID: mdl-36987735

RESUMO

Chronic exposure to stress or unwanted stimuli has been known to activate kappa opioid receptor/dynorphin (KOR/DYN) systems, which could induce depressive states and develop into some psychiatric disorders. Here, we report the first discovery of pyrazoloisoquinoline-based novel KOR ß-arrestin inverse agonists through synthesis, structure-activity relationships, optimization, and the biological evaluations of µ/κ/δ opioid receptor activities with cAMP and ß-arrestin recruitment assays. The optimized compound 7q shows potent and selective ß-arrestin inverse agonism at KOR with an EC50 value of 9.33 nM in contrast to lower activities at DOR and no activity at MOR. Moreover, we use molecular dynamics simulations to predict the binding mode of the inverse agonist and propose a mechanism for the inverse agonism. We find that the transmembrane helix 6 position of the activated state is different for the OR subtypes, leading to significantly different interactions between the receptor and ß-arrestin.


Assuntos
Agonismo Inverso de Drogas , Receptores Opioides kappa , Humanos , Receptores Opioides kappa/metabolismo , beta-Arrestinas/metabolismo , Dinorfinas/metabolismo , Relação Estrutura-Atividade , Receptores Opioides mu/metabolismo
16.
ACS Appl Mater Interfaces ; 15(12): 15758-15767, 2023 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-36930863

RESUMO

Three donor-acceptor-type thermally activated delayed fluorescence (TADF) emitters (PXZBAO (1), PXZBTO (2), and PXZBPO (3)) comprising a phenoxazine (PXZ) donor and differently π-expanded boron-carbonyl (BCO) hybrid acceptor units are proposed. The emitters exhibit red (1) to orange (3) emissions with an increase in the π-expansion in the BCO acceptors. The control of the strength of local aromaticity for the BCO unit and the corresponding LUMO level is attributed to inducing the unusual emission color shifts. The photoluminescence quantum yield and delayed fluorescence lifetime of the emitters are also adjusted by the π-expansion. Notably, although 1 possesses a 3nπ* state in the acceptor unit as a local triplet excited state (3LE, T2), the T2 states of 2 and 3 mainly comprise a 3ππ* state in the acceptor. Consequently, all of the emitters exhibit strong spin-orbit coupling between their T2 and excited singlet (S1) states, leading to a fast reverse intersystem crossing with rate constants of ∼106 s-1. By employing the emitters as dopants, we realize efficient red-to-orange TADF-OLEDs. Maximum external quantum efficiencies of 17.7% for the yellowish-orange (3), 15.5% for the orange (2), and 13.9% for the red (1) devices are achieved, and the values are very close to the theoretical limit predicted from the optical simulation.

17.
ACS Nano ; 2023 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-36633192

RESUMO

A highly reproducible route for the epitaxial growth of single-crystalline monolayer MoS2 on a C-plane sapphire substrate was developed using vapor-pressure-controllable inorganic molecular precursors MoOCl4 and H2S. Microscopic, crystallographic, and spectroscopic analyses indicated that the epitaxial MoS2 film possessed outstanding electrical and optical properties, excellent homogeneity, and orientation selectivity. The systematic investigation of the effect of growth temperature on the crystallographic orientations of MoS2 revealed that the surface termination of the sapphire substrate with respect to the growth temperature determines the crystallographic orientation selectivity of MoS2. Our results suggest that controlling the surface to form a half-Al-terminated surface is a prerequisite for the epitaxial growth of MoS2 on a C-plane sapphire substrate. The insights on the growth mechanism, especially the significance of substrate surface termination, obtained through this study will aid in designing efficient epitaxial growth routes for developing single-crystalline monolayer transition metal dichalcogenides.

18.
Retina ; 43(1): 120-129, 2023 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-36165992

RESUMO

PURPOSE: To investigate bilateral macular features on optical coherence tomography in patients with unilateral peripheral exudative hemorrhagic chorioretinopathy (PEHCR). METHODS: In this cross-sectional study, optical coherence tomography features of affected eyes (PEHCR group, n = 30) and unaffected contralateral eyes (contralateral group, n = 30) were investigated. Age-matched and sex-matched patients with polypoidal choroidal vasculopathy (PCV group, n = 51) and healthy controls (normal group, n = 50) were included to compare choroidal thickness, measured at six points apart from the fovea, with the PEHCR group. RESULTS: Subretinal drusenoid deposits were the most common feature in the PEHCR (20%) and contralateral (23%) groups, followed by soft drusen. Although the macular choroid was comparably thin in both the PEHCR and contralateral groups, pachyvessels were also observed. The choroids of the PEHCR group were significantly thinner than those of the normal group at the subfovea and 1-mm temporal to the fovea and considerably thinner than those of the polypoidal choroidal vasculopathy group from 3-mm nasal to 3-mm temporal to the fovea. CONCLUSION: In patients with unilateral PEHCR, bilateral choroidal thinning and drusenoid deposit accumulation were noted in the macula. The pathophysiology of PEHCR may be a rare peripheral complication of age-related macular degeneration with pathologic choroid.


Assuntos
Doenças da Coroide , Drusas Retinianas , Humanos , Estudos Transversais , Angiofluoresceinografia , Doenças da Coroide/diagnóstico , Doenças da Coroide/patologia , Corioide/patologia , Drusas Retinianas/diagnóstico , Drusas Retinianas/etiologia , Drusas Retinianas/patologia , Tomografia de Coerência Óptica , Estudos Retrospectivos
19.
Diabetes Metab J ; 47(1): 135-139, 2023 01.
Artigo em Inglês | MEDLINE | ID: mdl-35487507

RESUMO

We compared the glycemic efficacy of treatment intensification between quadruple oral antidiabetic drug therapy and once-weekly glucagon-like peptide-1 receptor agonist (GLP-1RA)-based triple therapy in patients with poorly controlled type 2 diabetes mellitus refractory to triple oral therapy. For 24 weeks, changes in glycosylated hemoglobin (HbA1c) from baseline were compared between the two treatment groups. Of all 96 patients, 50 patients were treated with quadruple therapy, and 46 were treated with GLP-1RA therapy. Reductions in HbA1c for 24 weeks were comparable (in both, 1.1% reduction from baseline; P=0.59). Meanwhile, lower C-peptide level was associated with a lower glucose-lowering response of GLP-1RA therapy (R=0.3, P=0.04) but not with quadruple therapy (R=-0.13, P=0.40). HbA1c reduction by GLP-1RA therapy was inferior to that by quadruple therapy in the low C-peptide subgroup (mean, -0.1% vs. -1.3%; P=0.04). Treatment intensification by switching to quadruple oral therapy showed similar glucose-lowering efficacy to weekly GLP-1RA-based triple therapy. Meanwhile, the therapeutic response was affected by C-peptide levels in the GLP-1RA therapy group but not in the quadruple therapy group.


Assuntos
Doenças Autoimunes , Diabetes Mellitus Tipo 2 , Humanos , Diabetes Mellitus Tipo 2/tratamento farmacológico , Hemoglobinas Glicadas , Insulina/uso terapêutico , Peptídeo C , Glicemia
20.
RSC Adv ; 12(46): 29892-29899, 2022 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-36321109

RESUMO

Highly fluorescent blue emitters with high color purity are of great significance for optical applications. Herein, a series of planarized B,N-diarylated benzonaphthoazaborine compounds, namely, BzNp (1), BuBzNp (2), Bu2BzNp (3), Bu2BzMeNp (4), and Bu2BzBuNp (5), where electron-donating t Bu and Me groups are differently introduced into the B-Ph, N-Ph, or benzoazaborine rings, are prepared and characterized. All compounds exhibit low-energy absorptions (λ abs = 462-467 nm) and emissions (λ PL = 472-478 nm) remarkably red-shifted compared with those found for the pristine dibenzoazaborine compound (404 and 415 nm, respectively). Although the expansion of π-conjugation in the azaborine ring by replacing one phenyl ring with a naphthyl ring is mainly responsible for the redshifts, the emission is also fine-tuned by attached alkyl groups, which have a greater impact on the B-centered LUMO level at the azaborine ring than at the B-Ph ring. The bandgap control and emission tuning are further supported by electrochemical and theoretical studies. Notably, blue to sky-blue fluorescence of all compounds exhibits unitary photoluminescence quantum yields, narrow full width at half maximum values (∼20 nm), and small Stokes shifts (∼11 nm), indicating strong emissions with high color purity.

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