RESUMO
Leaves of Eugenia jambolana yielded the new flavonol, myricetin 3-O-(4"-acetyl)-alpha-L-rhamnopyranoside (1).
Assuntos
Flavonoides/química , Glicosídeos/química , Myrtaceae , Fitoterapia , Humanos , Extratos Vegetais/química , Folhas de PlantaRESUMO
A partir do fracionamento em coluna de gel de sílica do extrato clorofórmico de Polygala paniculata (Polygalaceae), foram isolados 7-metóxi-8-(1',2'-epóxi-3'-metil-3'-butenil)-cumarina (1) e dois artefatos cumarínicos (2a-2b), formados a partir da abertura do anel epóxido de 1 durante o processo de isolamento. O tratamento de 1 com EtOH/SiO2, sob agitação e à temperatura ambiente durante 24 horas, resultou na formação dos respectivos artefatos: 7-metóxi-8-(1'-hidróxi-2-etóxi-3'-metil-3'-butenil)-cumarina (2a) e 7-metóxi-8-(1'-etóxi-2-hidróxi-3'-metil-3'-butenil)-cumarina (2b). As estruturas químicas desses compostos foram determinadas através da análise de seus dados espectrais, incluindo RMN bidimensional.
Fractionation of a chloroform extract of Polygala paniculata (Polygalaceae) on silica gel column chromatography yielded 7-methoxy-8-(1',2'-epoxy-3'-methyl-3'-butenyl)-coumarin (1) and two coumarinic artifacts (2a-2b). The reaction of 1 with EtOH/SiO2 at room temperature for 24 hours yielded 7-methoxy-8-(1'-hydroxy-2'-ethoxy-3'-methyl-3'-butenyl)-coumarin (2a) and 7-methoxy-8-(1'-ethoxy-2'-hydroxy-3'-methyl-3'-butenyl)-coumarin (2b). The structures have been determined by spectral data, including 2D NMR experiments.
RESUMO
Along with three known drimanes, polygodial. 1-beta-(p-methoxycinnamoyl) polygodial and mukaadial, the sesquiterpene drimane named drimanial was isolated from the bark of Drimys winteri (Winteraceae). Its structure was elucidated based on spectroscopic evidence. Drimanial exhibited antinociceptive action against acetic acid induced pain, being about 3-fold less active than polygodial.
Assuntos
Analgésicos/farmacologia , Magnoliopsida/química , Sesquiterpenos/farmacologia , Espectroscopia de Ressonância Magnética , Sesquiterpenos Policíclicos , Sesquiterpenos/química , Análise EspectralRESUMO
Extracts and fractions rich in flavonoids from fruits and leaves of Vitex polygama Cham. (Verbenaceae) were tested against acyclovir-resistant herpes simplex virus type 1 (ACV-HSV-1). Both fruit and leaf extracts exhibited a dose-dependent antiviral activity. The extract from the leaves showed intracellular antiviral activity while the extract from the fruits had virucidal effect. A fraction from the ethyl actetate extract of the leaves inhibited virus propagation by blocking HEp-2 cell receptors.
Assuntos
Aciclovir/farmacologia , Antivirais/farmacologia , Flavonoides/farmacologia , Herpesvirus Humano 1/efeitos dos fármacos , Extratos Vegetais/farmacologia , Vitex , Relação Dose-Resposta a Droga , Frutas/química , Humanos , Folhas de Planta/química , Células Tumorais CultivadasRESUMO
Two dihydrostyrylpyrones and a styrylpyrone were isolated from Polygala sabulosa, together with five known styrylpyrones. Their structures were established on the basis of spectral evidence as 4-methoxy-6-(11,12-methylenedioxy-14-methoxydihydrostyryl)-2-pyrone, 4-methoxy-6-(11,12-methylenedioxy-10,14-dimethoxydihydrostyryl)-2-pyrone, and 4-methoxy-6-(11,12-methylenedioxy-14-methoxystyryl)-2-pyrone.
Assuntos
Pironas/isolamento & purificação , Rosales/química , Estrutura Molecular , Pironas/química , Análise EspectralRESUMO
The present work describes the antinociceptive effects of some fractions and two pure compounds obtained from the Wedelia paludosa, a Brazilian medicinal plant employed in folk medicine against a variety of diseases, including dolorous pathologies. It was found that such fractions as well as kaurenoic acid and luteolin exhibit marked antinociceptive action in mice using acetic acid-induced writhing. They were more active than some well-known analgesic drugs, such as acetyl salicylic acid, acetaminophen, dipyrone and indomethacin. The results confirm our previous studies conducted with this plant, suggesting that different chemical constituents are responsible for the antinociceptive activity shown by the extracts and fractions prepared from W. paludosa.
Assuntos
Analgésicos não Narcóticos/farmacologia , Anti-Inflamatórios não Esteroides/farmacologia , Medicina Tradicional , Dor/tratamento farmacológico , Plantas Medicinais , Abdome , Acetaminofen/farmacologia , Ácido Acético , Analgésicos não Narcóticos/administração & dosagem , Animais , Aspirina/farmacologia , Brasil , Dipirona/farmacologia , Diterpenos/isolamento & purificação , Diterpenos/farmacologia , Flavonoides/isolamento & purificação , Flavonoides/farmacologia , Indometacina/farmacologia , Luteolina , Masculino , Camundongos , Extratos Vegetais/farmacologiaRESUMO
An original compound, named karalicin, was isolated from a fermentation broth of the Pseudomonas fluorescens/putida strain SS-3 (CCM 4430). Production, physico-chemical properties and structure elucidation are described.
Assuntos
Anisóis/química , Anisóis/metabolismo , Antivirais/química , Antivirais/metabolismo , Pentanóis/química , Pentanóis/metabolismo , Anisóis/isolamento & purificação , Antivirais/isolamento & purificação , Fenômenos Químicos , Físico-Química , Fermentação , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Pentanóis/isolamento & purificação , Pseudomonas fluorescens/classificação , Pseudomonas fluorescens/metabolismo , Pseudomonas putida/classificação , Pseudomonas putida/metabolismoRESUMO
The biological activities of karalicin, a new product from the Pseudomonas fluorescens/putida strain SS-3 (CCM 4430) are described. It shows a weak, but specific and irreversible, antiviral activity on Herpes simplex viruses. It also presents some inhibitory activity on different species of yeasts.
Assuntos
Anisóis/farmacologia , Antivirais/farmacologia , Pentanóis/farmacologia , Animais , Anisóis/química , Anisóis/metabolismo , Antifúngicos/química , Antifúngicos/metabolismo , Antifúngicos/farmacologia , Antivirais/química , Antivirais/metabolismo , Candida/efeitos dos fármacos , Morte Celular/efeitos dos fármacos , Linhagem Celular , Chlorocebus aethiops , Herpesvirus Humano 1/efeitos dos fármacos , Herpesvirus Humano 1/crescimento & desenvolvimento , Herpesvirus Humano 2/efeitos dos fármacos , Estrutura Molecular , Pentanóis/química , Pentanóis/metabolismo , Poliovirus/efeitos dos fármacos , Pseudomonas fluorescens/metabolismo , Pseudomonas putida/metabolismo , Vaccinia virus/efeitos dos fármacos , Células Vero , Leveduras/efeitos dos fármacosRESUMO
The isolation of the cyclopeptide alkaloids, adoutine-Y', discarine-B, discarine-E, and discarine-X, a new 14-membered cyclopeptide alkaloid from D. longispina, are reported. The structure of the new alkaloid was elucidated by spectroscopic methods and by chemical degradation.
Assuntos
Alcaloides/isolamento & purificação , Peptídeos Cíclicos/isolamento & purificação , Plantas Medicinais/química , Alcaloides/química , Argentina , Brasil , Espectroscopia de Ressonância Magnética , Peptídeos Cíclicos/química , Raízes de Plantas/química , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
A fraction obtained from the culture fluids of Pycnoporus sanguineus fungus was shown to contain a compound with biological activity against strains of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and members of the genus Streptococcus. The fraction was clearly more active on Gram-positive cocci than on Gram-negative bacilli.
Assuntos
Anti-Infecciosos/farmacologia , Bactérias/efeitos dos fármacos , Polyporaceae/metabolismo , Antibacterianos , Anti-Infecciosos/isolamento & purificação , Anti-Infecciosos/metabolismo , Fracionamento Químico , Cromatografia em Camada Fina , Meios de Cultura , Escherichia coli/efeitos dos fármacos , Klebsiella pneumoniae/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Pseudomonas aeruginosa/efeitos dos fármacos , Salmonella typhi/efeitos dos fármacos , Espectrofotometria Ultravioleta , Staphylococcus aureus/efeitos dos fármacos , Streptococcus/efeitos dos fármacosRESUMO
Vismiones and ferruginins, representatives of a new class of lypophilic anthranoids from the genusVismia were found to inhibit feeding in larvae of species ofSpodoptera, Heliothis, and inLocusta migratoria.
RESUMO
The alkaloid and procyanidin composition of Uncaria sp. from eastern Peru, used in folk medicine was studied. Five alkaloids have been separated and identified as pteropodine, speciophylline, isopteropodine, uncarine F and isomytraphylline, all belonging to the oxindole group characteristic of the Rubiaceae. Moreover (--) epicatechin and four dimeric procyanidins A1, B1, B2 and B4 have been shown to constitute the polyphenolic fraction of the plant extract.
Assuntos
Alcaloides/isolamento & purificação , Plantas Medicinais , Espectroscopia de Ressonância Magnética , Peru , Espectrofotometria InfravermelhoRESUMO
The authors present the first observations on the isolation of two quinonoid compounds from Hyptis fructicosa Salzm ex Benth; Labiatae. The referred naturally compounds present antimicrobial and antineoplastic activity against Gram-positive microrganisms and mouse Erlich carcionama, respectivelly.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Extratos Vegetais/isolamento & purificação , Plantas Medicinais , Quinonas/isolamento & purificação , Animais , Antineoplásicos Fitogênicos/uso terapêutico , Bactérias/efeitos dos fármacos , Carcinoma de Ehrlich/tratamento farmacológico , Avaliação de Medicamentos , Resistência Microbiana a Medicamentos , Métodos , Camundongos , Testes de Sensibilidade Microbiana , Transplante de Neoplasias , Neoplasias Experimentais/tratamento farmacológico , Fitoterapia , Extratos Vegetais/uso terapêutico , Quinonas/uso terapêutico , Sarcoma 180/tratamento farmacológicoRESUMO
In this paper the authors present the first report concerning the biological effects of a diterpene isolated from Croton aff. argyrophylloides Muell. Arg (Euphorbiaceae). Some biological and physiochemical properties of the antibiotic, named argyrophillic acid, were appreciated in comparison with those presented by cunabic acid, an antibiotic isolated from Icthyothere cunabi. The authors still show the microbial action of the abietic acid and confront it with that of the argyrophilic acid, the new antibiotic here reported.