Assuntos
Anemia/tratamento farmacológico , Darbepoetina alfa/uso terapêutico , Eritropoetina/uso terapêutico , Hematínicos/uso terapêutico , Insuficiência Renal Crônica/tratamento farmacológico , Anemia/complicações , Darbepoetina alfa/farmacologia , Eritropoetina/farmacologia , Hematínicos/farmacologia , Hemoglobinas , Humanos , Falência Renal Crônica , Proteínas Recombinantes , Diálise Renal , Insuficiência Renal Crônica/complicaçõesRESUMO
Experiments were designed to elucidate the differences, if any, in the liver histology induced by aflatoxin B in newborn and adult animals. The transfer of toxic metabolites from pregnant rats to their litters was confirmed by thin layer chromatography of liver homogenates in the latter. Extensive cystic lesions of the biliary and hepatic type developed only in young animals. Multifocal hepatic necrosis, bile ductular proliferation, areas of altered hepatocytes, neoplastic nodules and hepatocellular carcinoma constituted the total spectrum in both adult and newborn animals. Increased susceptibility to the toxins early in life appears to be responsible for this intriguing phenomenon. These aspects may have a bearing on the genesis of childhood liver disease.