[Endolymphatic antibiotic administration in the combined treatment of peritonitis]. / Endolimfaticheskoe vvedenie antibiotikov v kompleksnom lechenii peritonita.

The endolymphatic method of infusion of antibiotics was used in 165 patients with acute inflammatory diseases of organs of the abdominal cavity, 84,8% of them recovered. A single endolymphatic infusion of a usual dose of the antibiotic makes a very high concentration of the drug in the lymphatic system and maintains a therapeutic concentration of the antibiotic in the lymph during a day. In the lymphatic nodes it retains for more than 2 weeks. The methods reduces acute inflammatory processes, makes the temperature and blood leukocytes normal and improves the general state of the patients resulting in their quicker recovery. The endolymphatic therapy with antibiotics is in good agreement with surgical and other conservative methods of treatment.

[Tetraolean pharmacokinetics in the lymph and blood in complicated, acute inflammatory diseases of the abdominal cavity organs]. / Farmakokinetika tetraoleana v limfe i krovi pri oslozhnennykh ostrykh vospalitel'nykh zabolevaniiakh organov briushnoi polosti.

The time-course of tetraolean concentrations (according to tetracycline) in the lymph, blood and urine of 10 patients with various complicated acute inflammatory diseases of the organs of the abdominal cavity was studied. It was found that tetraolean used intramuscularly in the early postoperative periods was well absorbed into the lymph, reached its maximum level within 2 hours and exceeded that in the blood. During the following 8 hours the concentration of the drug in the lymph decreased but still remained much higher than that in the blood. Lymph sorption lowered the antibiotic lymph level to 30 per cent, which indicated the necessity of an adequate increase in the drug dose.

[Experimental study of a new method of endolymphatic antibiotic administration and a trial of its clinical use]. / Eksperimental'noe izuchenie novogo metoda éndolimfaticheskogo vvedeniia antibiotikov i opyt ego klinicheskogo primeneniia.

A new procedure for antibiotic administration via endolymphatic route was developed. Experiments performed on 34 dogs revealed differences in the pharmacokinetics of gentamicin in the central lymph after its administration in a dose of 4 mg/kg via endolymphatic and intramuscular routes: the maximum levels of 590 and 23 mg/kg were determined in 15 and 45 minutes respectively. In 1 hour the concentrations decreased to 17 and 10 mg/kg. When gentamicin was administered endolymphatically it remained in the lymph and blood in concentrations of 0.2 and 0.8 mg/kg respectively for 24 hours. The kinetics of gentamicin in the blood serum within the first 6 hours after its administration by both routes did not differ significantly. After endolymphatic administration high concentrations of gentamicin (56-36 mg/g) were determined in the paraaortal and retroperitoneal lymph nodes in 10-24 hours. Within the period of the 4th to the 13th day its concentrations of at least 5 mg/g were detected. The changes in the structure of the lymph nodes observed 18-48 hours after the antibiotic endolymphatic administration were reversible and returned to normal by the 96th hour. The first experience with the clinical use of the endolymphatic route of gentamicin administration showed its high efficacy in 84.8% of the patients with severe purulent inflammatory diseases of the organs of the abdominal cavity. The antibiotic was used in a dose of 80 mg once a day. The treatment course consisted of 5-6 infusions. Perspectives of the further experimental and clinical investigation of the procedure are indicated. Endolymphatic administration of antibiotics makes it possible to increase the efficacy of antibiotic therapy of a number of severe inflammatory infections.

[Kanamycin sulfate pharmacokinetics in the lymph and blood in complicated acute inflammatory diseases of the abdominal cavity organs]. / Farmakokinetika kanamitsina sul'fata v limfe i krovi pri oslozhnennykh ostrykh vospalitel'nykh zabolevaniiakh organov briushnoi polosti.

Pharmacokinetics of kanamycin sulfate in the lymph, blood and urine of 12 patients with acute inflammatory diseases of the organs of the abdominal cavity was studied. The study showed that kanamycin sulfate administered intramuscularly was rapidly absorbed into the lymph and blood reaching the maximum levels within 2 hours of the administration. The therapeutic levels were preserved for at least 8 hours. The concentration of kanamycin in pure lymph by the method of lymphosorption was 20 per cent lower which was connected with the drug adsorption by the sorbents.

[Detoxification of the body by means of lymphosorption in wound peritonitis]. / Detoksikatsiia organizma metodom limfosorbtsii pri ranevom peritonite.

Lymphosorption was used in 23 patients with diffuse wound peritonitis within 4--6 days in the complex of measures in order to detoxicate the organism. It resulted, as a rule, in decreased ammonemia, normalized residual nitrogen and urea and in the disappearance of erythrocytes from the lymph. Eighteen patients recovered, 5 patients died of progressing peritonitis and hepatic insufficiency.

[Ampicillin pharmacokinetics in the lymph and blood in acute inflammatory diseases of the abdominal cavity organs]. / Farmakokinetika ampitsillina v limfe i krovi pri ostrykh vospalitel'nykh zabolevaniiakh organov briushnoi polosti.

Ampicillin levels in the lymph, blood and urine were studied in 15 patients with various inflammatory diseases of the organs of the abdominal cavity. It was found that ampicillin administered intramuscularly to such patients at early postoperative periods was well absorbed not only to the blood but also to the lymph, reaching in parallel its maximum levels in an hour. After that the drug concentration in the lymph persisted for 6 hours and markedly exceeded that in the blood. Adsorption of the lymph lowered the antibiotic concentration in it to 25 per cent indicating the necessity for increasing the drug therapeutic doses.