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OBJECTIVES: to identify cardiovascular risk and cardiovascular risk factors in adolescents and verify correlations between these variables and biochemical markers, and between blood pressure percentiles, Body Mass Index, and biochemical markers. METHODS: a cross-sectional study, conducted at a Brazilian school, from August to September 2019, including 205 participants who were interviewed. After the interview, anthropometric assessments, including weight, height, arm circumference, blood pressure checking, and blood collection for laboratory tests were performed. Descriptive and inferential analysis using the chi-square test was conducted. RESULTS: a total of 18.5% had blood pressure percentiles >95%, 25.4% were overweight, and 25.9% were at very high cardiovascular risk. Statistically significant associations were found between cardiovascular risk and sex, Body Mass Index and blood pressure percentiles, and between blood pressure percentiles and triglycerides. CONCLUSIONS: high prevalence of risk factors among school adolescents reinforces the need for interventions for cardiovascular risk reduction in this population.
Assuntos
Doenças Cardiovasculares , Hipertensão , Adolescente , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/etiologia , Estudos Transversais , Fatores de Risco de Doenças Cardíacas , Humanos , Hipertensão/epidemiologia , Fatores de RiscoRESUMO
ABSTRACT Objectives: to identify cardiovascular risk and cardiovascular risk factors in adolescents and verify correlations between these variables and biochemical markers, and between blood pressure percentiles, Body Mass Index, and biochemical markers. Methods: a cross-sectional study, conducted at a Brazilian school, from August to September 2019, including 205 participants who were interviewed. After the interview, anthropometric assessments, including weight, height, arm circumference, blood pressure checking, and blood collection for laboratory tests were performed. Descriptive and inferential analysis using the chi-square test was conducted. Results: a total of 18.5% had blood pressure percentiles >95%, 25.4% were overweight, and 25.9% were at very high cardiovascular risk. Statistically significant associations were found between cardiovascular risk and sex, Body Mass Index and blood pressure percentiles, and between blood pressure percentiles and triglycerides. Conclusions: high prevalence of risk factors among school adolescents reinforces the need for interventions for cardiovascular risk reduction in this population.
RESUMO Objetivos: identificar o risco cardiovascular e os fatores de risco cardiovascular em adolescentes e verificar correlações entre essas variáveis e marcadores bioquímicos, e entre percentis de pressão arterial, Índice de Massa Corporal e marcadores bioquímicos. Métodos: estudo transversal, realizado em escola brasileira, de agosto-setembro de 2019, incluindo 205 participantes que foram entrevistados. Após a entrevista, foram realizadas avaliações antropométricas, incluindo peso, altura, circunferência do braço, aferição da pressão arterial e coleta de sangue. Foi realizada análise descritiva e inferencial por meio do Teste do Qui-Quadrado. Resultados: 18,5% apresentavam percentis de pressão arterial>95%, 25,4% com sobrepeso e 25,9% com risco cardiovascular muito alto. Foram encontradas associações estatisticamente significativas entre risco cardiovascular e sexo, Índice de Massa Corporal e percentis de pressão arterial e entre percentis de pressão arterial e triglicérides. Conclusões: a alta prevalência de fatores de risco em adolescentes escolares reforça a necessidade de intervenções para redução do risco cardiovascular nessa população.
RESUMEN Objetivos: identificar riesgo cardiovascular y factores de riesgo cardiovascular en adolescentes y verificar las correlaciones entre estas variables y marcadores bioquímicos, y entre percentiles de presión arterial, Índice de Masa Corporal y marcadores bioquímicos. Métodos: estudio transversal, realizado en una escuela brasileña, de agosto a septiembre de 2019, que incluyó a 205 participantes que fueron entrevistados. Después de la entrevista, se realizaron evaluaciones antropométricas que incluyeron peso, talla, perímetro del brazo, medición de la presión arterial y extracción de sangre para pruebas de laboratorio. El análisis descriptivo e inferencial se realizó mediante la prueba de chi-cuadrado. Resultados: el 18,5% tenía percentiles de presión arterial>95%, el 25,4% tenía sobrepeso y el 25,9% tenía un riesgo cardiovascular muy alto.Se encontraron asociaciones estadísticamente significativas entre el riesgo cardiovascular y el sexo, el Índice de Masa Corporal y los percentiles de presión arterial, y entre los percentiles de presión arterial y los triglicéridos. Conclusiones: la alta prevalencia de factores de riesgo en estudiantes adolescentes refuerza la necesidad de intervenciones para reducir el riesgo cardiovascular en esta población.
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Abstract Obesity and dyslipidemia are conditions often associated with cardiovascular risk, inflammation, oxidative stress, and death. Thus, a new approach has been highlighted to promote research and development of pharmacological tools derived from natural sources. Among the most widely studied groups of substances, polyphenols such as tyramine stand out. This study investigated hypolipidemic and anti-obesity properties of tyramine. Oral toxicity evaluation, models of dyslipidemia and obesity were used. To induce dyslipidemia, Poloxamer-407 (P-407) was administered intraperitoneally. In the hypercholesterolemic and obesity model, specific diet and oral tyramine were provided. After 24h of P-407 administration, tyramine 2 mg/kg (T2) decreased triglycerides (TG) (2057.0 ± 158.5 mg/dL vs. 2838 ± 168.3 mg/dL). After 48h, TG were decreased by T2 (453.0 ± 35.47 vs. 760.2 ± 41.86 mg/dL) and 4 mg/kg (T4) (605.8 ± 26.61 760.2 ± 41.86 mg/dL). T2 reduced total cholesterol (TC) after 24h (309.0 ± 11.17 mg/dL vs. 399.7 ± 15.7 mg/dL); After 48h, 1 mg/kg (T1) (220.5 ± 12.78 mg/dL), T2 (205.8 ± 7.1 mg/dL) and T4 (216.8 ± 12.79 mg/dL), compared to P-407 (275.5 ± 12.1 mg/dL). The treatment decreased thiobarbituric acid reactive substances and nitrite in liver, increased superoxide dismutase, reduced the diet-induced dyslipidemia, decreasing TC around 15%. Tyramine reduced body mass, glucose, and TC after hypercaloric feed. Treatment with 5 mg/L (0.46 ± 0.04 ng/dL) and 10 mg/L (0.44 ± 0.02 ng/dL) reduced plasma insulin (1.18 ± 0.23 ng/dL). Tyramine increased adiponectin at 5 mg/L (1.02 ± 0.02 vs. 0.83 ± 0.02 ng/mL) and 10mg/L (0.96 ± 0.04 ng/mL). In conclusion, tyramine has low toxicity in rodents, has antioxidant effect, reduces plasma triglycerides and cholesterol levels. However, further studies should be conducted in rodents and non-rodents to better understand the pharmacodynamic and pharmacokinetic properties of tyramine
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Tiramina/efeitos adversos , Hipolipemiantes/farmacologia , Obesidade/classificação , Colesterol/farmacologia , Hiperlipidemias/complicaçõesRESUMO
Objetivo: Identificar e avaliar as evidências científicas em relação ao conhecimento de estudantesuniversitáriossobre os fatores de risco de Doenças Cardiovasculares(DCV). Método: Trata-se de revisão integrativa, realizada em 2020, nas bases de dados MEDLINE, CINAHL,PubMed,Scopus e Web of Science.Baseado na pergunta norteadora, foi feita a busca dos artigos, utilizando-se descritores "Estudantes", "Universidades", "Conhecimento", "Doenças cardiovasculares" e "Fatores de riscos"e seus correspondentes em inglês.Resultados: Dos 17 artigos incluídos, 6 estavam disponíveis no Scopuse todos estavam em língua inglesa. Observou-se que estudantes tinham baixos níveis de conhecimento sobre osfatores de risco de DCV e não reconheciam a vulnerabilidade a elas, além de não adotarem medidas preventivas e um estilo de vida saudável.As publicações sugeriram a necessidade de profissionais de saúde em ambientes educacionais, visando aprimorar o conhecimento relacionado à saúde, incorporar práticas de estilo de vida saudáveis e desenvolver estratégias de redução dos níveis de risco de DCV. Conclusão:O aprofundamento do conhecimento e o olhar crítico sobre a literatura apontaram carência na produção de estudosbrasileiros sobre a temática, despertando a necessidade de condução de mais pesquisas e revisões da literatura para fortalecimento da prática baseada em evidências.
Objective: To identify and assess scientific evidence regarding university students' knowledge about risk factors for Cardiovascular Diseases (CVD). Method: This is an integrative review, carried out in 2020, in the MEDLINE, CINAHL, PubMed, Scopus, and Webof Science databases. Based on the guiding question, the search for articles was made, using the descriptors "Students", "Universities", "Knowledge", "Cardiovascular Diseases", and "Risk Factors" and their correspondents in English.Results:Of the 17 articles included, six were available from Scopus, and all were in English. It was observed that students have a low level of knowledge about risk factors for CVD and do not recognize their vulnerability to them, and not adopting preventive measures and a healthy lifestyle. Publications suggestedthe need for health professionals in educational settings to improve knowledge related to health, incorporate healthy lifestyle practices, and develop strategies to reduce CVD risk levels.Conclusion:Thedeepening of knowledge and a critical look at the literature showed a lack in producing Brazilian studies on the subject, arousing the need to conduct more research and literature reviews to strengthen evidence-based practice.
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Humanos , Masculino , Feminino , Estudantes , Universidades , Doenças Cardiovasculares , Fatores de Risco , ConhecimentoRESUMO
Objetivo: o estudo objetivou investigar os hábitos, o conhecimento sobre higiene oral e o comportamento em saúde bucal bem como o acesso aos serviços odontológicos de estudantes brasileiros e principalmente estudantes africanos, recém-ingressos à universidade.Sujeitos e método: trata-se de estudo exploratório, descritivo,transversal e quantitativo, conduzido em universidade pública brasileira. Após assinatura do termo e consentimento livre e esclarecido, foi aplicado um questionário aos acadêmicos. Os dados foram tabuladose analisados. Resultados: entre os brasileiros, 90%escovavam os dentes no mínimo 3 vezes ao dia, 50%não utilizavam fio dental, 55% não faziam uso de colutório,e 80% higienizavam a língua. Entre os estrangeiros,55% escovavam 2 vezes ao dia, 85% não usavamfio dental, 80% não utilizavam colutório, e 65%higienizavam a língua. Todos os brasileiros conheciam fio dental e colutório, enquanto que 70% dos acadêmicos estrangeiros sabiam o que era fio dental, e 60%desconheciam o que era colutório. Observou-se uma associação entre ser estudante estrangeiro e não utilizar fio dental. Dos participantes, 95% dos brasileiros e 50%dos estrangeiros já tinham buscado atendimento odontológico.Sobre a autopercepção de higiene bucal, 95%dos brasileiros e 60% dos estrangeiros consideravam-na boa. Constatou-se ainda uma relação entre ser acadêmico recém-ingresso e ter uma boa percepção de higiene oral sem utilizar fio dental. Conclusão: concluiu-se que há diferenças entre hábitos, conhecimento e comportamento em saúde bucal de acadêmicos de acordo com anacionalidade. A pesquisa contribuiu para caracterização,comparação e relação de importantes variáveis em saúde bucal nos contextos universitário e étnico. (AU)
Objective: the study aimed to investigate the oral hygiene habits and knowledge, and the oral health behavior, as well as the access to dental services of Brazilian and international students recently admitted to the university. Subjects and method: this is an exploratory, descriptive, cross-sectional, and quantitative study conducted in a Brazilian public university. After signing the Informed Consent Form, a questionnaire was applied to the students. The data were tabulated and analyzed. Results: among the Brazilian students, 90% brushed their teeth at least 3 times a day, 50% did not use dental floss, 55% did not use mouthwash, and 80% cleaned their tongue. Among the international students, 55% brushed their teeth 2 times a day, 85% did not use dental floss, 80% did not use mouthwash, and 65% cleaned their tongue. All Brazilians were aware of dental floss and mouthwash, while 70% of international students knew dental floss and 60% were unaware of the mouthwash. There was an association between being an international student and not using dental floss. From the participants, 95% of Brazilians and 50% of international students had already sought dental care. Regarding oral hygiene self-perception, 95% of Brazilians and 60% of international students considered it satisfactory. Additionally, being a newly enrolled student and having a good perception of oral hygiene were associated with not using dental floss. Conclusion: it was concluded that there are differences between oral health habits, knowledge, and behavior of students according to nationality. The research contributed to the characterization, comparison, and association of major oral health variables in the university and ethnic context. (AU)
