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1.
Sci Rep ; 14(1): 10502, 2024 05 07.
Artigo em Inglês | MEDLINE | ID: mdl-38714849

RESUMO

We aimed to conduct a proof-of-concept study of INV-001 in visualizing lymphatic vessels and nodes without venous contamination and to determine the optimal dose condition of INV-001 for magnetic resonance lymphangiography (MRL) in healthy beagles. MRL was performed using a 3.0-Tesla (T) whole body clinical magnetic resonance imaging (MRI) scanner. A dose-finding study of INV-001 for MRL in beagles (N = 6) was carried out according to an adaptive optimal dose finding design. For the reproducibility study (N = 6), MRL was conducted at selected INV-001 doses (0.056 and 0.112 mg Fe/kg) with a 15 mM concentration. Additionally, an excretion study (N = 3) of INV-001 was conducted by analyzing T1, T2, and T2* maps of the liver and kidney 48 h post-administration. INV-001 administration at doses of 0.056 and 0.112 mg Fe/kg (concentration: 15 mM) consistently demonstrated the visualization of contrast-enhanced lymphatic vessels and nodes without venous contamination in the beagles. The contrast enhancement effect was highest at 30 min after INV-001 administration, then gradually decreasing. No toxicity-related issues were identified during the study. After 48 h, the T1, T2, and T2* values in the liver and both kidneys were found to be comparable to the pre-administration values, indicating thorough INV-001 excretion. The optimal dosing conditions of INV-001 for MRL for contrast-enhanced visualization of lymphatic vessels and nodes exclusively with no venous contamination in beagles was determined to be 0.056 mg Fe/kg with a 15 mM concentration.


Assuntos
Meios de Contraste , Vasos Linfáticos , Linfografia , Imageamento por Ressonância Magnética , Animais , Cães , Imageamento por Ressonância Magnética/métodos , Linfografia/métodos , Meios de Contraste/administração & dosagem , Vasos Linfáticos/diagnóstico por imagem , Masculino , Reprodutibilidade dos Testes , Feminino , Linfonodos/diagnóstico por imagem , Estudo de Prova de Conceito
2.
BMC Geriatr ; 24(1): 407, 2024 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-38714958

RESUMO

BACKGROUND: Quality of life of osteoporosis patients had caused widespread concern, due to high incidence and difficulty to cure. Scale specifics for osteoporosis and suitable for Chinese cultural background lacked. This study aimed to develop an osteoporosis scale in Quality of Life Instruments for Chronic Diseases system, namely QLICD-OS (V2.0). METHODS: Procedural decision-making approach of nominal group, focus group and modular approach were adopted. Our scale was developed based on experience of establishing scales at home and abroad. In this study, Quality of life measurements were performed on 127 osteoporosis patients before and after treatment to evaluate the psychometric properties. Validity was evaluated by qualitative analysis, item-domain correlation analysis, multi-scaling analysis and factor analysis; the SF-36 scale was used as criterion to carry out correlation analysis for criterion-related validity. The reliability was evaluated by the internal consistency coefficients Cronbach's α, test-retest reliability Pearson correlation r. Paired t-tests were performed on data of ​​the scale before and after treatment, with Standardized Response Mean (SRM) being calculated to evaluate the responsiveness. RESULTS: The QLICD-OS, composed of a general module (28 items) and an osteoporosis-specific module (14 items), had good content validity. Correlation analysis and factor analysis confirmed the construct, with the item having a strong correlation (most > 0.40) with its own domains/principle components, and a weak correlation (< 0.40) with other domains/principle components. Correlation coefficient between the similar domains of QLICD-OS and SF-36 showed reasonable criterion-related validity, with all coefficients r being greater than 0.40 exception of physical function of SF-36 and physical domain of QLICD-OS (0.24). Internal consistency reliability of QLICD-OS in all domains was greater than 0.7 except the specific module. The test-retest reliability coefficients (Pearson r) in all domains and overall score are higher than 0.80. Score changes after treatment were statistically significant, with SRM ranging from 0.35 to 0.79, indicating that QLICD-OS could be rated as medium responsiveness. CONCLUSION: As the first osteoporosis-specific quality of life scale developed by the modular approach in China, the QLICD-OS showed good reliability, validity and medium responsiveness, and could be used to measure quality of life in osteoporosis patients.


Assuntos
Osteoporose , Qualidade de Vida , Humanos , Qualidade de Vida/psicologia , Feminino , Masculino , Osteoporose/psicologia , Osteoporose/diagnóstico , Idoso , Doença Crônica , Pessoa de Meia-Idade , Inquéritos e Questionários/normas , Reprodutibilidade dos Testes , Psicometria/métodos , Psicometria/instrumentação , Psicometria/normas , Idoso de 80 Anos ou mais
3.
Cardiovasc Diabetol ; 23(1): 158, 2024 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-38715055

RESUMO

BACKGROUND: The association between iron biomarkers and cardiovascular disease risk factors (CVD-RFs) remains unclear. We aimed to (1) evaluate the cross-sectional and longitudinal associations between iron biomarkers (serum ferritin, transferrin saturation (TSAT), transferrin) and CVD-RFs among women, and (2) explore if these associations were modified by menopausal status. METHOD: Cross-sectional and longitudinal analyses including 2542 and 1482 women from CoLaus cohort, respectively. Multiple linear regression and multilevel mixed models were used to analyse the associations between Iron biomarkers and CVD-RFs. Variability of outcomes and iron markers between surveys was accessed using intraclass correlation (ICC). RESULTS: After multivariable adjustment, elevated serum ferritin levels were associated with increased insulin and glucose levels, while higher transferrin levels were linked to elevated glucose, insulin and total cholesterol, and systolic and diastolic blood pressure (p < 0.05). No association was observed between CVD-RFs and TSAT (p > 0.05). Iron biomarkers demonstrated low reliability across reproductive stages but exhibited stronger associations in the perimenopausal group. In longitudinal analysis, we found association only for transferrin with lower glucose levels [ß = - 0.59, 95% CI (- 1.10, - 0.08), p = 0.02] and lower diastolic blood pressure [ß = - 7.81, 95% CI (- 15.9, - 0.56), p = 0.04]. CONCLUSION: In cross-sectional analysis, transferrin was associated with several CVD-RFs, and the associations did not change according to menopausal status. Conversely, in the longitudinal analyses, changes in transferrin were associated only with lower glucose and diastolic blood pressure levels. These differences might stem from the substantial longitudinal variation of iron biomarkers, underscoring the need for multiple iron measurements in longitudinal analyses.


Assuntos
Biomarcadores , Doenças Cardiovasculares , Ferritinas , Fatores de Risco de Doenças Cardíacas , Pós-Menopausa , Transferrina , Humanos , Feminino , Biomarcadores/sangue , Estudos Transversais , Pessoa de Meia-Idade , Ferritinas/sangue , Estudos Longitudinais , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/sangue , Transferrina/metabolismo , Transferrina/análise , Pós-Menopausa/sangue , Medição de Risco , Adulto , Ferro/sangue , Fatores de Tempo , Brasil/epidemiologia , Idoso , Glicemia/metabolismo , Reprodutibilidade dos Testes , Fatores Etários
4.
Korean J Intern Med ; 39(3): 439-447, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38715232

RESUMO

BACKGROUND: Helicobacter pylori infection, prevalent in more than half of the global population, is associated with various gastrointestinal diseases, including peptic ulcers and gastric cancer. The effectiveness of early diagnosis and treatment in preventing gastric cancer highlights the need for improved diagnostic methods. This study aimed to develop a simple scoring system based on endoscopic findings to predict H. pylori infection. METHODS: A retrospective analysis was conducted on 1,007 patients who underwent upper gastrointestinal endoscopy at Asan Medical Center from January 2019 to December 2021. Exclusion criteria included prior H. pylori treatment, gastric surgery, or gastric malignancies. Diagnostic techniques included rapid urease and 13C-urea breath tests, H. pylori culture, and assessment of endoscopic features following the Kyoto gastritis classification. A new scoring system based on endoscopic findings including regular arrangement of collecting venules (RAC), nodularity, and diffuse or spotty redness was developed for predicting H. pylori infection, utilizing logistic regression analysis in the development set. RESULTS: The scoring system demonstrated high predictive accuracy for H. pylori infection in the validation set. Scores of 2 and 3 were associated with 96% and 99% infection risk, respectively. Additionally, there was a higher prevalence of diffuse redness and sticky mucus in cases where the initial H. pylori eradication treatment failed. CONCLUSION: Our scoring system showed potential for improving diagnostic accuracy in H. pylori infection. H. pylori testing should be considered upon spotty redness, diffuse redness, nodularity, and RAC absence on endoscopic findings as determined by the predictive scoring system.


Assuntos
Infecções por Helicobacter , Helicobacter pylori , Valor Preditivo dos Testes , Humanos , Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/microbiologia , Infecções por Helicobacter/tratamento farmacológico , Estudos Retrospectivos , Masculino , Feminino , Pessoa de Meia-Idade , Helicobacter pylori/isolamento & purificação , Helicobacter pylori/efeitos dos fármacos , Adulto , Idoso , Testes Respiratórios , Endoscopia Gastrointestinal , Reprodutibilidade dos Testes , Gastrite/microbiologia , Gastrite/diagnóstico , Medição de Risco , Técnicas de Apoio para a Decisão
5.
Skin Res Technol ; 30(5): e13690, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38716749

RESUMO

BACKGROUND: The response of AI in situations that mimic real life scenarios is poorly explored in populations of high diversity. OBJECTIVE: To assess the accuracy and validate the relevance of an automated, algorithm-based analysis geared toward facial attributes devoted to the adornment routines of women. METHODS: In a cross-sectional study, two diversified groups presenting similar distributions such as age, ancestry, skin phototype, and geographical location was created from the selfie images of 1041 female in a US population. 521 images were analyzed as part of a new training dataset aimed to improve the original algorithm and 520 were aimed to validate the performance of the AI. From a total 23 facial attributes (16 continuous and 7 categorical), all images were analyzed by 24 make-up experts and by the automated descriptor tool. RESULTS: For all facial attributes, the new and the original automated tool both surpassed the grading of the experts on a diverse population of women. For the 16 continuous attributes, the gradings obtained by the new system strongly correlated with the assessment made by make-up experts (r ≥ 0.80; p < 0.0001) and supported by a low error rate. For the seven categorical attributes, the overall accuracy of the AI-facial descriptor was improved via enrichment of the training dataset. However, some weaker performance in spotting specific facial attributes were noted. CONCLUSION: In conclusion, the AI-automatic facial descriptor tool was deemed accurate for analysis of facial attributes for diverse women although some skin complexion, eye color, and hair features required some further finetuning.


Assuntos
Algoritmos , Face , Humanos , Feminino , Estudos Transversais , Adulto , Face/anatomia & histologia , Face/diagnóstico por imagem , Estados Unidos , Pessoa de Meia-Idade , Adulto Jovem , Fotografação , Reprodutibilidade dos Testes , Inteligência Artificial , Adolescente , Idoso , Pigmentação da Pele/fisiologia
6.
PLoS One ; 19(5): e0303102, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38718000

RESUMO

BACKGROUND: Disability is an important multifaceted construct. A brief, generic self-reported disability questionnaire that promises a broader and more comparable measure of disability than disease-specific instruments does not currently exist. The aim of this study was to develop and evaluate such a questionnaire: the Universal Disability Index (UDI). METHODS: An online survey was used to collect general population data. Data were randomly divided into training and validation subsets. The dimensionality and structure of eight UDI questionnaire items were evaluated using exploratory factor analysis (EFA, training subset) followed by confirmatory factor analysis (CFA, validation subset). To assess concurrent validity, the UDI summed score from the full dataset was compared to the Groningen Activity Restriction Scale (GARS) and the Graded Chronic Pain Scale (GCPS) disability scores. Internal consistency and discriminant validity were also assessed. Bootstrapping was used to evaluate model stability and generalisability. RESULTS: 403 participants enrolled; 364 completed at least one UDI item. Three single-factor versions of the UDI were assessed (8-item, 7-item, and 6-item). All versions performed well during EFA and CFA (182 cases assigned to each), but none met the RMSEA (Root Mean Square Error of Approximation) criterion (≤ 0.08). All versions of the UDI had high internal consistency (Cronbach's α > 0.90), were strongly correlated (Pearson's r > 0.7) with both GARS and GCPS disability scores, indicating concurrent validity, and could accurately discriminate between upper and lower quartiles of these comparators. Confidence intervals of estimates were narrow, suggesting model stability and generalisability. CONCLUSIONS: A brief, generic self-reported disability questionnaire was found to be valid and to possess good psychometric properties. The UDI has a single factor structure and either a 6-item, 7-item or 8-item version can be used to measure disability. For brevity and parsimony, the 6-item UDI is recommended, but further testing of all versions is warranted.


Assuntos
Avaliação da Deficiência , Pessoas com Deficiência , Autorrelato , Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Adulto , Inquéritos e Questionários/normas , Análise Fatorial , Idoso , Psicometria/métodos , Reprodutibilidade dos Testes , Adulto Jovem
7.
PLoS One ; 19(5): e0298872, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38718011

RESUMO

BACKGROUND: Effectively managing their athletic and academic projects is a major challenge for student-athletes. The salience of the identity they develop in each of these contexts can affect their well-being and is therefore an important variable to consider. Examining these mechanisms in countries and student-athlete support systems other than the United States is also important. AIM: This study aims to both translate and evaluate the psychometric properties of a French version of the Academic and Athletic Identity Scale, the AAIS-FR, and to examine the additive and interactive relationships of the two identities with sport burnout and engagement. METHODS: Participants were 359 French student-athletes (50.42% female) who were competing at various levels (ranging from regional to international). RESULTS: Results from analyses using a slightly modified version of the original scale provided evidence of construct (i.e., factor structure) and concurrent (i.e., expected relationships between both identities and several correlates identified in previous work) validity, as well as reliability (i.e., internal consistency) and invariance across gender and sport competition levels of the AAIS-FR. In addition, regression analyses revealed a favourable relationship between athletic identity and sport well-being (i.e., positive with engagement and negative with burnout), no relationship between academic identity and sport well-being, and no interaction between the two identities. CONCLUSION: While further research is needed to provide additional evidence for the validity of the AAIS-FR, researchers can still use this tool to measure the salience of the two identities of French-speaking student-athletes.


Assuntos
Atletas , Psicometria , Esportes , Humanos , Feminino , Masculino , Atletas/psicologia , Psicometria/métodos , Esportes/psicologia , Adulto Jovem , Inquéritos e Questionários , Reprodutibilidade dos Testes , França , Estudantes/psicologia , Adolescente , Adulto
8.
PLoS One ; 19(5): e0302787, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38718077

RESUMO

To monitor the sharing of research data through repositories is increasingly of interest to institutions and funders, as well as from a meta-research perspective. Automated screening tools exist, but they are based on either narrow or vague definitions of open data. Where manual validation has been performed, it was based on a small article sample. At our biomedical research institution, we developed detailed criteria for such a screening, as well as a workflow which combines an automated and a manual step, and considers both fully open and restricted-access data. We use the results for an internal incentivization scheme, as well as for a monitoring in a dashboard. Here, we describe in detail our screening procedure and its validation, based on automated screening of 11035 biomedical research articles, of which 1381 articles with potential data sharing were subsequently screened manually. The screening results were highly reliable, as witnessed by inter-rater reliability values of ≥0.8 (Krippendorff's alpha) in two different validation samples. We also report the results of the screening, both for our institution and an independent sample from a meta-research study. In the largest of the three samples, the 2021 institutional sample, underlying data had been openly shared for 7.8% of research articles. For an additional 1.0% of articles, restricted-access data had been shared, resulting in 8.3% of articles overall having open and/or restricted-access data. The extraction workflow is then discussed with regard to its applicability in different contexts, limitations, possible variations, and future developments. In summary, we present a comprehensive, validated, semi-automated workflow for the detection of shared research data underlying biomedical article publications.


Assuntos
Pesquisa Biomédica , Fluxo de Trabalho , Pesquisa Biomédica/métodos , Humanos , Disseminação de Informação/métodos , Acesso à Informação , Reprodutibilidade dos Testes
9.
Child Care Health Dev ; 50(3): e13267, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38722088

RESUMO

BACKGROUND: Maternal parenting self-efficacy plays a critical role in facilitating positive parenting practices and successful adaption to motherhood. The Perceived Maternal Parenting Self-Efficacy Scale (PMPS-E), as a task-specific measure, confirms its psychometric properties in cultural contexts. Compared with other tools, the advantages of the PMPS-E are as follows: (i) specific context or time period during the lifespan of a child, (ii) explicitly assess parenting self-efficacy across a diverse enough range of parenting tasks or activities during the perinatal/postnatal period and (iii) having robust psychometric properties. The aim of this study was to translate and determine the psychometric properties of the PMPS-E among Chinese postpartum women (C-PMPS-E). METHOD: The cross-cultural adaptation process followed Beaton et al.'s intercultural debugging guidelines. A total of 471 women were included to establish the psychometric properties of the C-PMPS-E. Mothers were asked to complete the C-PMPS-E, Edinburgh Postnatal Depression Scale (EPDS), the Generalized Anxiety Disorder-7 (GAD-7) and several demographic questions. The psychometric testing of the C-PMPS-E was established through item analysis, construct validity and internal consistency reliability. RESULTS: Item analysis showed that the critical ratios of all items were greater than 3 between the low-score group and high-score group, and all item-total correlation coefficients were greater than 0.4. The fit indices showed that the original correlated four-factor model of C-PMPS-E was observed to be an excellent fit to the data. The PMPS-E was negatively correlated with the EPDS and GAD-7 demonstrating its discriminant validity. As expected, no significant correlation was found between PMPS-E total or subscale scores and mothers' age. In addition, statistically significant differences for parity were detected for C-PMPS-E total and subscale scores with multipara having higher scores. This was taken as further evidence of the scale known-groups discriminant validity. In terms of internal consistency, the Cronbach's alpha of the C-PMPS-E total scale was 0.950, and subscales ranged from 0.76 to 0.89. Furthermore, a ROC curve analysis was conducted to establish the ability of the C-PMPS-E to distinguish between symptoms of depression and symptoms of anxiety. A cut-off value of 55 was identified that resulted in good specificity and fair sensitivity. CONCLUSION: The C-PMPS-E is a reliable and valid tool to assess maternal parenting self-efficacy in a Chinese context.


Assuntos
Mães , Poder Familiar , Período Pós-Parto , Psicometria , Autoeficácia , Humanos , Feminino , Adulto , Poder Familiar/psicologia , Período Pós-Parto/psicologia , Reprodutibilidade dos Testes , Mães/psicologia , China , Inquéritos e Questionários/normas , Adulto Jovem , Traduções , Depressão Pós-Parto/psicologia , Depressão Pós-Parto/diagnóstico
10.
Lasers Med Sci ; 39(1): 121, 2024 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-38722564

RESUMO

To develop and validate a 3D simulation model to calculate laser ablation (LA) zone size and estimate the volume of treated tissue for thyroid applications, a model was developed, taking into account dynamic optical and thermal properties of tissue change. For validation, ten Yorkshire swines were equally divided into two cohorts and underwent thyroid LA at 3 W/1,400 J and 3 W/1,800 J respectively with a 1064-nm multi-source laser (Echolaser X4 with Orblaze™ technology; ElEn SpA, Calenzano, Italy). The dataset was analyzed employing key statistical measures such as mean and standard deviation (SD). Model simulation data were compared with animal gross histology. Experimental data for longitudinal length, width (transverse length), ablation volume and sphericity were 11.0 mm, 10.0 mm, 0.6 mL and 0.91, respectively at 1,400 J and 14.6 mm, 12.4 mm, 1.12 mL and 0.83, respectively at 1,800 J. Gross histology data showed excellent reproducibility of the ablation zone among same laser settings; for both 1,400 J and 1,800 J, the SD of the in vivo parameters was ≤ 0.7 mm, except for width at 1,800 J, for which the SD was 1.1 mm. Simulated data for longitudinal length, width, ablation volume and sphericity were 11.6 mm, 10.0 mm, 0.62 mL and 0.88, respectively at 1,400 J and 14.2 mm, 12.0 mm, 1.06 mL and 0.84, respectively at 1,800 J. Experimental data for ablation volume, sphericity coefficient, and longitudinal and transverse lengths of thermal damaged area showed good agreement with the simulation data. Simulation datasets were successfully incorporated into proprietary planning software (Echolaser Smart Interface, Elesta SpA, Calenzano, Italy) to provide guidance for LA of papillary thyroid microcarcinomas. Our mathematical model showed good predictability of coagulative necrosis when compared with data from in vivo animal experiments.


Assuntos
Terapia a Laser , Glândula Tireoide , Animais , Terapia a Laser/métodos , Terapia a Laser/instrumentação , Glândula Tireoide/cirurgia , Glândula Tireoide/patologia , Suínos , Simulação por Computador , Modelos Teóricos , Reprodutibilidade dos Testes
11.
J Med Internet Res ; 26: e57963, 2024 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-38722675

RESUMO

BACKGROUND: As digital health services are increasingly developing and becoming more interactive in Serbia, a comprehensive instrument for measuring eHealth literacy (EHL) is needed. OBJECTIVE: This study aimed to translate, culturally adapt, and investigate the psychometric properties of the Serbian version of the eHealth Literacy Questionnaire (eHLQ); to evaluate EHL in the population of primary health care (PHC) users in Serbia; and to explore factors associated with their EHL. METHODS: The validation study was conducted in 8 PHC centers in the territory of the Macva district in Western Serbia. A stratified sampling method was used to obtain a representative sample. The Translation Integrity Procedure was followed to adapt the questionnaire to the Serbian language. The psychometric properties of the Serbian version of the eHLQ were analyzed through the examination of factorial structure, internal consistency, and test-retest reliability. Descriptive statistics were calculated to determine participant characteristics. Differences between groups were tested by the 2-tailed Students t test and ANOVA. Univariable and multivariable linear regression analyses were used to determine factors related to EHL. RESULTS: A total of 475 PHC users were enrolled. The mean age was 51.0 (SD 17.3; range 19-94) years, and most participants were female (328/475, 69.1%). Confirmatory factor analysis validated the 7-factor structure of the questionnaire. Values for incremental fit index (0.96) and comparative fit index (0.95) were above the cutoff of ≥0.95. The root mean square error of approximation value of 0.05 was below the suggested value of ≤0.06. Cronbach α of the entire scale was 0.95, indicating excellent scale reliability, with Cronbach α ranging from 0.81 to 0.90 for domains. The intraclass correlation coefficient ranged from 0.63 to 0.82, indicating moderate to good test-retest reliability. The highest EHL mean scores were obtained for the understanding of health concepts and language (mean 2.86, SD 0.32) and feel safe and in control (mean 2.89, SD 0.33) domains. Statistically significant differences (all P<.05) for all 7 eHLQ scores were observed for age, education, perceived material status, perceived health status, searching for health information on the internet, and occupation (except domain 4). In multivariable regression models, searching for health information on the internet and being aged younger than 65 years were associated with higher values of all domain scores except the domain feel safe and in control for variable age. CONCLUSIONS: This study demonstrates that the Serbian version of the eHLQ can be a useful tool in the measurement of EHL and in the planning of digital health interventions at the population and individual level due to its strong psychometric properties in the Serbian context.


Assuntos
Atenção Primária à Saúde , Telemedicina , Humanos , Sérvia , Atenção Primária à Saúde/métodos , Atenção Primária à Saúde/estatística & dados numéricos , Adulto , Feminino , Pessoa de Meia-Idade , Inquéritos e Questionários/normas , Masculino , Telemedicina/métodos , Telemedicina/estatística & dados numéricos , Traduções , Adulto Jovem , Idoso , Letramento em Saúde/estatística & dados numéricos , Psicometria/métodos , Reprodutibilidade dos Testes
12.
Rev Colomb Psiquiatr (Engl Ed) ; 53(1): 26-31, 2024.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-38724169

RESUMO

OBJECTIVE: The aim of the present study was to verify the psychometric qualities of the PID-5-FBF in a community sample of Brazilian adults. The internal consistency of the facets and the internal structure of the dimensions were checked. In addition, we verified the correlations between the PID-5-FBF facets and domains with a five-factor model measure. METHODS: The sample of this study consists of the 774 Brazilian adults aged 18 to 73 years (mean 28.9±11.58) who answered the PID-5-FBF and BFI-2S. RESULTS: The alpha values were adequate. The internal structure was similar to the PID-5 original form. All the factors and dimensions of the PID-5-FBF have a negative association with agreeableness, while, on the other hand, all correlations with neuroticism were positive. Neuroticism was the factor with the highest correlation with the PID-5-FBF, and openness was the one with the lowest number of correlations. CONCLUSIONS: This research contributes to adding evidence of validity to the PID-5-FBF in the Brazilian community sample. Our results are important because it is the first study with the PID-FBF in a Brazilian sample.


Assuntos
Manual Diagnóstico e Estatístico de Transtornos Mentais , Inventário de Personalidade , Psicometria , Humanos , Brasil , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Adulto Jovem , Idoso , Adolescente , Reprodutibilidade dos Testes
13.
Pharmacoepidemiol Drug Saf ; 33(5): e5787, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38724471

RESUMO

PURPOSE: Real-world evidence (RWE) is increasingly used for medical regulatory decisions, yet concerns persist regarding its reproducibility and hence validity. This study addresses reproducibility challenges associated with diversity across real-world data sources (RWDS) repurposed for secondary use in pharmacoepidemiologic studies. Our aims were to identify, describe and characterize practices, recommendations and tools for collecting and reporting diversity across RWDSs, and explore how leveraging diversity could improve the quality of evidence. METHODS: In a preliminary phase, keywords for a literature search and selection tool were designed using a set of documents considered to be key by the coauthors. Next, a systematic search was conducted up to December 2021. The resulting documents were screened based on titles and abstracts, then based on full texts using the selection tool. Selected documents were reviewed to extract information on topics related to collecting and reporting RWDS diversity. A content analysis of the topics identified explicit and latent themes. RESULTS: Across the 91 selected documents, 12 topics were identified: 9 dimensions used to describe RWDS (organization accessing the data source, data originator, prompt, inclusion of population, content, data dictionary, time span, healthcare system and culture, and data quality), tools to summarize such dimensions, challenges, and opportunities arising from diversity. Thirty-six themes were identified within the dimensions. Opportunities arising from data diversity included multiple imputation and standardization. CONCLUSIONS: The dimensions identified across a large number of publications lay the foundation for formal guidance on reporting diversity of data sources to facilitate interpretation and enhance replicability and validity of RWE.


Assuntos
Farmacoepidemiologia , Farmacoepidemiologia/métodos , Humanos , Reprodutibilidade dos Testes , Coleta de Dados/métodos , Coleta de Dados/normas , Fonte de Informação
14.
Port J Card Thorac Vasc Surg ; 31(1): 29-32, 2024 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-38743517

RESUMO

INTRODUCTION: Ankle-Brachial Index (ABI) is a well-established diagnostic tool for evaluating peripheral arterial disease (PAD). Limitations in its application led to the development of alternative diagnostic methods, including Toe-Brachial Index (TBI) and Transcutaneous Pressure of Oxygen (TcPO2), yet these are not as widely available as ABI. Recently, Pedal Acceleration Time (PAT), has gained popularity as a new tool to assess PAD, requiring only an ultrasound. This study seeks to further establish the correlation between ABI and PAT, determining whether PAT can be a reliable alternative for diagnosing and assessing the severity of PAD. METHODS: ABI and PAT were measured in patients attending our consult with no history of vascular or endovascular surgery. Limbs with unmeasurable ABI were excluded. Patients were categorized into groups based on their PAD stage according to the Fontaine classification. Patient demographics, comorbidities and respective ABI and PAT were analysed. RESULTS: Sixty-nine patients (114 limbs) were included in the study. Mean age 68 ± 11.7 years, 78.3% male and 33.3% diabetic patients. Fifty-three claudicant limbs (46.5%) and 26 limbs (22.8%) with chronic limb threatening ischemia. Pearson correlation coefficient between ABI and PAT, showed a strong negative correlation (r= -0.78; p<0.01). Mean ABI and PAT for limbs in Fontaine stage I were 0.94 ± 0.17 and 82.0 ± 27.4 ms; Fontaine stage IIa 0.69 ± 0.21 and 141.3 ± 57.8 ms; Fontaine stage IIb 0.54 ± 0.14 and 173.4 ± 65.1 ms; Fontaine stage III 0.43 ± 0.15 and 216 ± 33.2 ms; Fontaine stage IV 0.49 ± 0.17 and 206.7 ± 78.1 ms, respectively. CONCLUSION: Our study suggests an inverse correlation between ABI and PAT, in accordance with the findings published in the literature, thus supporting the use of PAT as an easily reproducible and efficient alternative to ABI for evaluating the severity of PAD.


Assuntos
Índice Tornozelo-Braço , Doença Arterial Periférica , Humanos , Masculino , Doença Arterial Periférica/fisiopatologia , Doença Arterial Periférica/diagnóstico , Índice Tornozelo-Braço/métodos , Feminino , Idoso , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Pé/irrigação sanguínea , Idoso de 80 Anos ou mais , Aceleração , Reprodutibilidade dos Testes
15.
Ann Ig ; 36(4): 476-486, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38747081

RESUMO

Background and aim: Preoperative surgical fear is an emotional reaction that can be observed in many patients who are waiting to undergo a surgical procedure. The Surgical Fear Questionnaire was originally developed to determine the level of fear in patients who are expected to undergo elective surgery. This study aims to test the validity and reliability of this Italian version in a population of patients waiting for major cardiac surgery. Study design: Methodological research model. Methods: The population of this methodological study included the patients who presented to Lecco Hospital in Italy between January 2022 and October 2023 and were scheduled to undergo valve surgery, aortic surgery or coronary surgery; the sample involved 416 patients who met the inclusion criteria. Results: Results of the analyses showed that the Surgical Fear Questionnaire can be used with two subscales; the "Surgical Fear Questionnaire-S", which shows the fear of the short-term consequences of cardiac-surgery, and the "Surgical Fear Questionnaire-L", which shows the fear of the long-term consequences of cardiac-surgery. The mean score of the patients was 26.32+9.23 on the former, 27.62+11.89 on the latter, and 53.94 +19.16 for the entire questionnaire. The Cronbach's α coefficient was 0.952 for the "Surgical Fear Questionnaire-S", 0.920 for the "Surgical Fear Questionnaire-L", and 0.914 for the entire questionnaire. Conclusion: Based on the validity and reliability tests, we consider the questionnaire adaptable to the Italian reality, specifically to the population waiting for major cardiac surgery.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Medo , Psicometria , Humanos , Itália , Procedimentos Cirúrgicos Cardíacos/psicologia , Masculino , Feminino , Inquéritos e Questionários , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Idoso , Procedimentos Cirúrgicos Eletivos/psicologia , Adulto
16.
Pak J Pharm Sci ; 37(1(Special)): 205-213, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38747271

RESUMO

In this study, a sensitive high-performance liquid chromatography detector was established and validated for the simultaneous determination of geniposide, ellagic acid, piperine, costunolide and dehydrocostuslactone in Liuwei Muxiang Capsules. The analysis was achieved on CHANIN 100-5-C18-H column (5µm, 250 mm×4.6 mm) with the temperature of 30oC. Gradient elution was applied using 0.1% phosphoric acid solution-methanol-acetonitrile (50:50) as mobile phase at the flow rate of 1.0 mL/min. The determination was performed at the wavelength of 225 nm (detecting geniposide), 254 nm (detecting ellagic acid), 343 nm (detecting piperine) and 225 nm (detecting costunolide and dehydrocostuslactone) along with the sample volume of 10µL. The linear ranges of geniposide, ellagic acid, piperine, costunolide and dehydrocostuslactone demonstrated good linear relationships within their respective determination ranges. The average recoveries were 100.04%, 99.86%, 99.79%, 100.17% and 100.41%, respectively. RSD% was 1.3%, 1.2%, 1.2%, 1.2%, 1.5%, respectively. The developed method was proved to be simple, accurate and sensitive, which can provide a quantitative analysis method for the content determination of geniposide, ellagic acid, piperine, costunolide and dehydrocostuslactone in Liuwei Muxiang capsules.


Assuntos
Alcaloides , Benzodioxóis , Cápsulas , Medicamentos de Ervas Chinesas , Ácido Elágico , Iridoides , Lactonas , Piperidinas , Alcamidas Poli-Insaturadas , Cromatografia Líquida de Alta Pressão/métodos , Benzodioxóis/análise , Alcamidas Poli-Insaturadas/análise , Piperidinas/análise , Piperidinas/química , Alcaloides/análise , Lactonas/análise , Medicamentos de Ervas Chinesas/química , Medicamentos de Ervas Chinesas/análise , Iridoides/análise , Ácido Elágico/análise , Reprodutibilidade dos Testes , Sesquiterpenos/análise
17.
Cien Saude Colet ; 29(5): e16892022, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38747778

RESUMO

The school is fundamental for the development of societies and caring for the student is part of the educational process. Reflections on collective health allowed the expansion of the vision of the concept of quality of life considering different social spaces and indicators. Thus, the aim of this study was to assess of some psychometric Properties of the Quality of Life in School instrument into Brazilian Portuguese (QoLS-BR) among elementary school students. The processes of translation, content evaluation, focus group and Confirmatory Factor Analysis (CFA) were carried out. Reproducibility analysis was performed by administering QoLS-BR to 30 students. The sample used for Internal Consistency and CFA comprised 434 students with a mean age of 12.31 years. High indices of language clarity, practical relevance, theoretical relevance, internal consistency, and reproducibility were obtained. In the AFC, adjustments were not necessary in the QoLS-BR model with four factors (RMSEA=0.065; TLI=0.959; CFI=0.962; SRMR=0.080) indicating that the indices were adequate when investigating all four domains. QoLS-BR has adequate psychometric indicators for investigating the quality of life in school.


Assuntos
Características Culturais , Idioma , Psicometria , Qualidade de Vida , Instituições Acadêmicas , Estudantes , Traduções , Humanos , Brasil , Masculino , Feminino , Criança , Adolescente , Estudantes/psicologia , Reprodutibilidade dos Testes , Inquéritos e Questionários , Comparação Transcultural , Análise Fatorial
18.
Braz Oral Res ; 38: e037, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38747824

RESUMO

Dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) can differentiate into osteoblasts, indicating that both are potential candidates for bone tissue engineering. Osteogenesis is influenced by many environmental factors, one of which is lipopolysaccharide (LPS). LPS-induced NF-κB activity affects the osteogenic potencies of different types of MSCs differently. This study evaluated the effect of LPS-induced NF-κB activity and its inhibition in DPSCs and PDLSCs. DPSCs and PDLSCs were cultured in an osteogenic medium, pretreated with/without NF-κB inhibitor Bay 11-7082, and treated with/without LPS. Alizarin red staining was performed to assess bone nodule formation, which was observed under an inverted light microscope. NF-κB and alkaline phosphatase (ALP) activities were measured to examine the effect of Bay 11-7082 pretreatment and LPS supplementation on osteogenic differentiation of DPSCs and PDLSCs. LPS significantly induced NF-κB activity (p = 0.000) and reduced ALP activity (p = 0.000), which inhibited bone nodule formation in DPSCs and PDLSCs. Bay 11-7082 inhibited LPS-induced NF-κB activity, and partially maintained ALP activity and osteogenic potency of LPS-supplemented DPSCs and PDLSCs. Thus, inhibition of LPS-induced NF-κB activity can maintain the osteogenic potency of DPSCs and PDLSCs.


Assuntos
Fosfatase Alcalina , Diferenciação Celular , Polpa Dentária , Lipopolissacarídeos , NF-kappa B , Nitrilas , Osteogênese , Ligamento Periodontal , Células-Tronco , Humanos , Lipopolissacarídeos/farmacologia , Ligamento Periodontal/citologia , Ligamento Periodontal/efeitos dos fármacos , Osteogênese/efeitos dos fármacos , Osteogênese/fisiologia , Polpa Dentária/citologia , Polpa Dentária/efeitos dos fármacos , NF-kappa B/metabolismo , Fosfatase Alcalina/análise , Diferenciação Celular/efeitos dos fármacos , Células-Tronco/efeitos dos fármacos , Células-Tronco/fisiologia , Células Cultivadas , Nitrilas/farmacologia , Sulfonas/farmacologia , Reprodutibilidade dos Testes , Fatores de Tempo , Adulto Jovem , Adolescente
19.
Braz Oral Res ; 38: e032, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38747819

RESUMO

This study assessed the reliability of a color measurement method using images obtained from a charge-coupled device (CCD) camera and a stereoscopic loupe. Disc-shaped specimens were created using the composite Filtek Z350 XT (shades DA1, DA2, DA3, and DA4) (n = 3). CIELAB color coordinates of the specimens were measured using the spectrophotometer SP60 over white and black backgrounds. Images of the same specimens were taken using a CCD camera attached to a stereoscopic loupe. The color of the image was measured (red-green-blue [RGB]) using an image processing software and converted to CIELAB coordinates. For each color coordinate, data from images were adjusted using linear regressions predicting those values from SP60. The whiteness index for dentistry (WID) and translucency parameter (TP00) of the specimens as well as the color differences (ΔE00) among pairwise shades were calculated. Data were analyzed via repeated-measures analysis of variance and Tukey's post hoc test (α = 0.05). Images obtained using the loupe tended to be darker and redder than the actual color. Data adjustment resulted in similar WID, ΔE00, and TP00 values to those observed for the spectrophotometer. Differences were observed only for the WID of shade DA3 and ΔE00 for comparing DA1 and DA3 over the black background. However, these differences were not clinically relevant. The use of adjusted data from images taken using a stereoscopic loupe is considered a feasible method for color measurement.


Assuntos
Cor , Colorimetria , Resinas Compostas , Teste de Materiais , Espectrofotometria , Reprodutibilidade dos Testes , Resinas Compostas/química , Espectrofotometria/métodos , Colorimetria/métodos , Colorimetria/instrumentação , Análise de Variância , Valores de Referência , Modelos Lineares , Processamento de Imagem Assistida por Computador/métodos
20.
Braz Oral Res ; 38: e039, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38747826

RESUMO

The aim of this study was to evaluate the convergence between the domains of the Autoquestionnaire Qualité de Vie Enfant image (AUQUEI) and the Child Perceptions Questionnaire (CPQ8-10) in the mixed dentition. A sample of 676 children aged 8 to 10 years responded to the health-related quality of life (HRQoL) and oral health-related quality of life (OHRQoL) questionnaires using the AUQUEI and the CPQ8-10, respectively. Clinical (dental caries and malocclusion) and socioeconomic variables were assessed. The validity of convergence between scores (total and per domain) of the two instruments was assessed by Spearman correlation analysis, considering that non-zero coefficient values represented a correlation between scores. The median was calculated to compare the scores of each questionnaire relative to the variables, and the nonparametric Mann-Whitney test was applied to determine statistically significant differences between the categories. A weak significant correlation (between 0.30 and 0.50) was observed between the domains and the total scores of instruments (p < 0.05), except for the leisure domain (p > 0.05). Participants with a lower family income had worse HRQoL (p < 0.05), and those with caries and malocclusion experience had worse OHRQoL (p < 0.05). In conclusion, the AUQUEI and CPQ8-10 instruments showed a weak correlation. Income and clinical variables had a negative impact on the AUQUEI and CPQ8-10, respectively.


Assuntos
Cárie Dentária , Dentição Mista , Má Oclusão , Saúde Bucal , Qualidade de Vida , Fatores Socioeconômicos , Humanos , Criança , Saúde Bucal/estatística & dados numéricos , Feminino , Masculino , Inquéritos e Questionários , Má Oclusão/psicologia , Estatísticas não Paramétricas , Cárie Dentária/psicologia , Reprodutibilidade dos Testes , Estudos Transversais , Valores de Referência
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