Dioctophyma renale em 28 cães: aspectos clinicopatológicos e ultrassonográficos / Dioctophyma renale in 28 dogs: clinicpathological and ultrasonographic findings

A infecção em cães por Dioctophyma renale, relatada em diversas partes do mundo, é considerada incomum, na maioria das vezes. No entanto, em algumas regiões são descritos números crescentes da infecção e muitos dados da epidemiologia e do ciclo biológico do parasito ainda são obscuros. Dessa forma, o trabalho tem como objetivo descrever os aspectos epidemiológicos, clinicopatológicos e ultrassonográficos de casos de infecção por Dioctophyma renale em cães na região da Fronteira Oeste do Rio Grande do Sul. Foram estudados 28 casos de dioctofimose em cães necropsiados ou clinicamente avaliados, submetidos à ultrassonografia e cirurgia para retirada dos parasitos. Os cães errantes foram os mais acometidos e todos com possível acesso às margens do Rio Uruguai. As lesões renais e extrarrenais foram caracterizadas predominantemente por atrofia do parênquima renal com glomerulonefrite esclerosante e peritonite granulomatosa associada a parasitos adultos livres na cavidade abdominal e ovos, bem como migrações erráticas para o tecido subcutâneo. Por fim, os achados ultrassonográficos corresponderam, especialmente, a imagens transversais circulares de até 0,6 cm de diâmetro, com margem hiperecoica e centro hipoecoico. Esses achados foram patognomônicos para infecção por Dioctophyma renale, e o exame ultrassonográfico se mostrou indispensável para o diagnóstico definitivo durante a avaliação clínica. Os achados observados nesse estudo demonstram a importância dessa parasitose na região. Além disso, alertam para a importância do diagnóstico, que vem sendo subestimado, além de apontar a necessidade de mais dados acerca da epidemiologia da doença para que se chegue a métodos efetivos de controle.(AU)

Dioctophyma renale infection in dogs is being considered uncommon for most parts of the world. However, some regions show an increase of this infection; but many data of the epidemiology and the biological cycle of the parasite are still unclear. The present study describes the epidemiological, clinicpathological and ultrasonographic aspects of 28 cases of infection by Dioctophyma renale in dogs in the West Frontier region of Rio Grande do Sul, Brazil. Street dogs were the most affected and all of them had access to the banks of the Uruguay River. The renal and extra-renal lesions were predominantly characterized by atrophy of the renal parenchyma, sclerotic glomerulonephritis and granulomatous peritonitis, associated with free adult parasites and eggs in the abdominal cavity and erratic migration into the subcutaneous tissue. The ultrasound findings corresponded especially to the circular cross-sectional images with 0.6cm in diameter at most, with hyperechoic margin and hypoechoic center too. These findings were pathognomonic for Dioctophyma renale infection and this examination was essential for the definitive diagnosis by clinical evaluation. The results of the study demonstrate the importance of this parasitism in the region, alert that the diagnosis has being underestimated, and point out the need to clarify its epidemiology in order to reach effective control measures.(AU)

Multiple congenital abnormalities in newborn domestic kittens / Anomalias congênitas múltiplas em felinos domésticos neonatos

Background: Congenital defects and diseases have hereditary or acquired etiology that affects domestic and wildlife animals, and humans. These anomalies are usually isolated and their location and intensity determine the survival of affected animals. Congenital malformations in domestic cats are less frequent than in dogs. Although some racial groups of cats seem to present greater predisposition to develop certain types of congenital defects and / or hereditary diseases, such information is controversial and has been discussed in several reports. Some malformations are rare in cats and poorly reported in Brazil and when they occur, mostly, are not identifi ed or the etiology is unknown.Case: This report describes the clinicopathological features of three newborn Persian kittens of the same dam. They were examined soon after birth because had multiple congenital malformations that involved the oral and nasal cavities, limbs, eyes, abdominal cavity and the vertebrae. The abnormalities were characterized by hyperextension in limbs and palatosquisis (Kittens 1, 2, and 3), unilateral and bilateral clinical anophthalmia (Kittens 1 and 3, respectively), unilateral cheiloschisis (Kittens 2), kyphosis, and abdominosquisis (1). At necropsy the Kitten 1 showed in the right eye socket rudiments of the eye covered with skin, and failure in the lining of the hard palate with bilateral hypop

Background: Congenital defects and diseases have hereditary or acquired etiology that affects domestic and wildlife animals, and humans. These anomalies are usually isolated and their location and intensity determine the survival of affected animals. Congenital malformations in domestic cats are less frequent than in dogs. Although some racial groups of cats seem to present greater predisposition to develop certain types of congenital defects and / or hereditary diseases, such information is controversial and has been discussed in several reports. Some malformations are rare in cats and poorly reported in Brazil and when they occur, mostly, are not identifi ed or the etiology is unknown.Case: This report describes the clinicopathological features of three newborn Persian kittens of the same dam. They were examined soon after birth because had multiple congenital malformations that involved the oral and nasal cavities, limbs, eyes, abdominal cavity and the vertebrae. The abnormalities were characterized by hyperextension in limbs and palatosquisis (Kittens 1, 2, and 3), unilateral and bilateral clinical anophthalmia (Kittens 1 and 3, respectively), unilateral cheiloschisis (Kittens 2), kyphosis, and abdominosquisis (1). At necropsy the Kitten 1 showed in the right eye socket rudiments of the eye covered with skin, and failure in the lining of the hard palate with bilateral hypop

Anaplastic Ventricular Adenocarcinoma in a Blue and Gold Macaw (Ara ararauna)

A case of anaplastic ventricular adenocarcinoma in an adult, female captive blue and gold macaw (Ara ararauna) is reported. The bird died suddenly and was submitted to necropsy. The carcass was in poor body condition. A pale, firm neoplastic mass was observed infiltrating the wall of the proventricular-ventricular junction. Histologically, the neoplasm consisted of a poorly demarcated and highly invasive proliferation of cuboidal to columnar neoplastic epithelial cells arranged into small groups and admixed with a dense desmoplastic reaction. Numerous neoplastic cells showed a finely fibrillar, Alcian blue-positive cytoplasmic material. Neoplastic cells were strongly positive for pancytokeratin and negative for vimentin. The diagnosis of anaplastic ventricular adenocarcinoma was based on histological, histochemical, and immunohistochemical findings. These neoplasms are uncommon in psittacine birds and to the best of our knowledge have not been reported in this species.(AU)

Anomalias congênitas múltiplas em felinos domésticos neonatos / Multiple congenital abnormalities in newborn domestic kittens

Background: Congenital defects and diseases have hereditary or acquired etiology that affects domestic and wildlife animals, and humans. These anomalies are usually isolated and their location and intensity determine the survival of affected animals. Congenital malformations in domestic cats are less frequent than in dogs. Although some racial groups of cats seem to present greater predisposition to develop certain types of congenital defects and / or hereditary diseases, such information is controversial and has been discussed in several reports. Some malformations are rare in cats and poorly reported in Brazil and when they occur, mostly, are not identified or the etiology is unknown. Case: This report describes the clinicopathological features of three newborn Persian kittens of the same dam. They were examined soon after birth because had multiple congenital malformations that involved the oral and nasal cavities, limbs, eyes, abdominal cavity and the vertebrae. The abnormalities were characterized by hyperextension in limbs and palatosquisis (Kittens 1, 2, and 3), unilateral and bilateral clinical anophthalmia (Kittens 1 and 3, respectively), unilateral cheiloschisis (Kittens 2), kyphosis, and abdominosquisis (1). At necropsy the Kitten 1 showed in the right eye socket rudiments of the eye covered with skin, and failure in the lining of the hard palate with bilateral hypoplasia of the soft palate. Microscopically, the microphthalmia was confirmed, and were observed dysplastic structures similar to the lens, retina and the ciliary body, and periocular glandular structures, as well as confirmed aplasia cutis in the hard palate with abrupt failure in the ectodermal and mesodermal tissues. Based on epidemiological findings, as well as the types of macroscopic and microscopic changes observed in this study, suggests hereditary component to the pathogenesis of these malformations. Discussion: The epidemiological and clinicopathological findings presented by the three Persian cats malformed suggested hereditary congenital abnormalities associated with high degree of inbreeding. Inbreeding corresponds to the crossing between individuals of the same family tree, it is reported in many species and allows unwanted remaining genes being passed on and increase the chances of defects and hereditary diseases in the offspring. Although many of these abnormalities are infrequent and many of them are rare in cats. Several reports point to possible etiologies associated with genetic defects and hereditary diseases in cats. However, there are many congenital abnormalities similar to those observed in this study developed after exposure to stressors during pregnancy, not observed in this work. In this study the association of multiple hereditary anomalies with changes occurring in the offspring are enhanced not only by the account of inbreeding in the cattery, but also by the data concerning the handling of animals, which ruled out the possibility of changes caused by medications or stress caused by the cat during pregnancy. Comparing the human species the chances of the conditions described in this report are inherited are high and can be seen as a consensus among most authors, that animals with these defects should not be introduced into breeding schemes. There are no reports of malformations similar to those observed in this study, occurring simultaneously in the feline species in Brazil. Because of possible hereditary etiology is recommended castration of animals which survive to the abnormalities.

Aspectos clinicopatológicos e laboratoriais do envenenamento experimental por Bothrops moojeni e Bothropoides neuwiedi em ovinos / Clinicopathological and laboratory aspects of experimental poisoning by Bothrops moojeni and Bothropoides neuwiedi snake venoms in sheep

O envenenamento ofídico espontâneo, ou acidente ofídico, é descrito como causa de morte em animais domésticos. No entanto, dados concretos relativos ao gênero e espécie de serpente envolvida, à evolução do quadro clínico, e às alterações clinicopatológicas desenvolvidas, são escassos. Assim sendo, este trabalho teve como objetivo determinar as alterações clinicopatológicas e laboratoriais provocadas pelo veneno de Bothrops moojeni e Bothropoides neuwiedi em ovinos no intuito de fornecer informações adicionais referentes a acidentes ofídicos em animais de produção, auxiliando o estabelecimento do diagnóstico dessa condição. Os venenos liofilizados foram diluídos em 1 ml de solução fisiológica e administrados a quatro ovinos por via subcutânea na face direita, nas doses de 0,41mg/kg e 0,82mg/kg do veneno de B. moojeni em dois ovinos, e de 1,0mg/kg do veneno de B. neuwiedi em dois ovinos. Apenas o ovino que recebeu a menor dose (0,41mg/kg) sobreviveu, apesar de ter desenvolvido quadro clínico muito severo e semelhante aos demais. Os sinais clínicos iniciaram nos primeiros 10 minutos após a inoculação em todos os ovinos. O período de evolução variou de dois a quatro dias. O quadro clínico dos quatro ovinos caracterizou-se por apatia, acentuado aumento de volume da face, da porção ventral do pescoço e do peito, leve aumento de volume da porção proximal dos membros anteriores, tempo de sangramento aumentado, taquicardia, mucosas pálidas e grande quantidade de sangue não digerido nas fezes. Ao exame laboratorial observou-se principalmente redução das proteínas plasmáticas e aumento de creatinaquinase em todos os ovinos. À necropsia, foram observados extensos hematomas nas áreas correspondentes ao aumento de volume subcutâneo. Observaram-se petéquias, equimoses e sufusões leves a moderadas na serosa de diversos órgãos e acúmulo de sangue em meio às fezes na porção final do reto. Além de hemorragias, a principal alteração histopatológica observada foi necrose das fibras musculares esqueléticas e da parede de vasos, nas áreas próximas à inoculação do veneno. Nos ovinos deste estudo o aumento de volume, observado na face, pescoço, peito e membros, era constituído por sangue.(AU)

Spontaneous envenoming by snake bite is described as a cause of death in domestic animals. However, there are just few information about the species of snake involved, course, and clinicopathological and laboratory findings. Thus, this research aimed to determine the clinicopathological and laboratory changes induced by Bothrops moojeni and Bothropoides neuwiedi snake venoms in sheep, in order to provide additional information regarding snakebites in farm animals and to help establish the diagnosis of this condition. The lyophilized snake venoms were dissolved in 1mL saline solution and administered subcutaneously into the right face of four sheep, at doses of 0.41mg/kg and 0.82mg/kg of B. moojeni venom for two sheep, and 1.0mg/kg of B. neuwiedi venom for two other sheep. Only the sheep which had received the lowest dose (0.41mg/kg) survived, but developed severe clinical signs, similar to the others. First clinical signs were observed about 10 minutes after inoculation in all sheep. The course varied from 2 to 4 days. The clinical findings in all sheep were characterized by apathy, marked swelling of the face, the ventral neck and esternal region, and mild swelling of the proximal portion of the forelimbs, as well as increased bleeding time, tachycardia, pale mucous membranes, and large quantity of undigested blood in the intestinal lumen. Laboratory exams showed mainly a reduction in serum protein and increased creatine kinase in all sheep. At necropsy, extensive hematomas were observed in the subcutaneous tissue of the swollen areas. Also petechiae, bruises and mild to moderate hemorrhagic suffusions on the serosa of various organs, and blood within the intestinal contents of the distal rectum were observed. In addition to hemorrhages, the main histopathological changes were necrosis of skeletal muscle fibers and blood vessel walls next to the inoculation site. The swollen areas on face, neck, sternum and limbs of the sheep were due the hematomas.(AU)

Linfossarcoma de células B multicêntrico em uma ovelha / Multicentric B-cell lymphosarcoma in an Ewe

Background: Lymphosarcoma is a malignant tumor from tumoral cells similar to lymphocytes and its spontaneous development in small ruminants is unusual in Brazil. In cattle, the lymphosarcomas are often associated with infection by bovine leukemia virus (BLV), although sheep are considered as a very susceptible specie to BLV. Spontaneously lymphosarcoma is rare and in most cases it is observed in apparently healthy animals in slaughterhouses. There is no report of this tumor in sheep in southern Brazil. We describe a case of spontaneous multicentric B-cells lymphosarcoma in an ewe. Case: In June 2007, a 4-years-old mixed breed ewe was necropsied after clinical signs as anorexia, weight loss and death in few weeks. This ewe was purchased in September 2006 with another 44 sheep, most females of the same age. Dairy cattle were also raised together with sheep at the same farm. Fragments of liver, lung, spleen, kidneys, brain and parotid lymph node were sent to the Veterinary Pathology Laboratory - Universidade Federal de Santa Maria, Brazil, for histopathological evaluation. Multiply white to yellow nodules, with 0.5 to 2 cm of diameter, were observed in the liver, kidneys, and the parotid lymph node. The nodules were soft and some coalesced and infiltrating the hepatic parenchyma. The kidneys nodules were similar to those of the liver but prominent in the capsule. They were observed infiltrating more intensely the cortical region. The parotid lymph node was 6 x 4 x 3.5 cm size, whitish, multilobulated and the cut surface was totally obliterated by the tumor mass. Histologically, the neoplasm showed intense proliferation of neoplastic lymphoid cells arranged in sheets and a poor fibrovascular stroma, with round small and hyperchromatic nuclei, and scarce eosinophilic cytoplasm compressing the adjacent parenchyma.(...)

Linfossarcoma de células B multicêntrico em uma ovelha / Multicentric B-cell lymphosarcoma in an Ewe

Background: Lymphosarcoma is a malignant tumor from tumoral cells similar to lymphocytes and its spontaneous development in small ruminants is unusual in Brazil. In cattle, the lymphosarcomas are often associated with infection by bovine leukemia virus (BLV), although sheep are considered as a very susceptible specie to BLV. Spontaneously lymphosarcoma is rare and in most cases it is observed in apparently healthy animals in slaughterhouses. There is no report of this tumor in sheep in southern Brazil. We describe a case of spontaneous multicentric B-cells lymphosarcoma in an ewe. Case: In June 2007, a 4-years-old mixed breed ewe was necropsied after clinical signs as anorexia, weight loss and death in few weeks. This ewe was purchased in September 2006 with another 44 sheep, most females of the same age. Dairy cattle were also raised together with sheep at the same farm. Fragments of liver, lung, spleen, kidneys, brain and parotid lymph node were sent to the Veterinary Pathology Laboratory - Universidade Federal de Santa Maria, Brazil, for histopathological evaluation. Multiply white to yellow nodules, with 0.5 to 2 cm of diameter, were observed in the liver, kidneys, and the parotid lymph node. The nodules were soft and some coalesced and infiltrating the hepatic parenchyma. The kidneys nodules were similar to those of the liver but prominent in the capsule. They were observed infiltrating more intensely the cortical region. The parotid lymph node was 6 x 4 x 3.5 cm size, whitish, multilobulated and the cut surface was totally obliterated by the tumor mass. Histologically, the neoplasm showed intense proliferation of neoplastic lymphoid cells arranged in sheets and a poor fibrovascular stroma, with round small and hyperchromatic nuclei, and scarce eosinophilic cytoplasm compressing the adjacent parenchyma.(...)(AU)

Sarcoide equino associado ao papilomavírus bovino BR-UEL-4

A 3-year-old, mixed breed, male horse showed multiple nodules in different areas of the skin. Lesions occurred predominantly on the lips, cheeks, and submandibular and right inguinal regions. The nodules were characterized as mixed, fibroblastic, verrucous and occult types of sarcoid. Histologically there was proliferation of dermal fibroblasts, with or without pseudoepitheliomatous hyperplasia of the epidermis (frequently ulcerated), and formation of small isolated groups of neoplastic fibroblasts in the superficial dermis. Three tissue samples were submitted to DNA extraction and PCR amplification with generic primers for the internal region of the papillomavirus L1 gene. The amplified products from two samples were sequenced and showed 99% identity with the bovine papillomavirus (BPV) BR-UEL-4. This is the first description of BPV BR-UEL-4 infecting a horse and causing sarcoid in this species. BPV BR-UEL-4 is a putative new BPV type recently identified in skin papillomas in a Brazilian cattle herd.

Um equino, sem raça definida, macho com três anos de idade apresentou múltiplos nódulos na pele, em diversas regiões do corpo. As lesões localizavam-se predominantemente nos lábios, nas bochechas, na região submandibular e na região inguinal direita. Os tumores caracterizavam-se como sarcoides dos tipos misto, fibroblástico, verrucoso e oculto. Histologicamente apresentaram proliferação de fibroblastos dérmicos, muitas vezes ulcerado, com ou sem hiperplasia pseudoepiteliomatosa da epiderme e formação de pequenos grupos isolados de fibroblastos neoplásicos na derme superficial. Três amostras de tecido foram submetidas à extração de DNA e amplificação por PCR com oligonucleotídeos iniciadores genéricos direcionados para uma região interna do gene L1 dos papilomavírus. Os produtos resultantes da amplificação de duas amostras foram sequenciados e demonstraram identidade de 99% com o papilomavírus bovino (BPV) BR-UEL-4. Essa é a primeira descrição da infecção de equinos, bem como de sua associação com sarcoide pelo BPV BR-UEL-4, um suposto novo tipo de BPV identificado recentemente no Brasil a partir de papilomas cutâneos em bovinos.

Sarcoide equino associado ao papilomavírus bovino BR-UEL-4

A 3-year-old, mixed breed, male horse showed multiple nodules in different areas of the skin. Lesions occurred predominantly on the lips, cheeks, and submandibular and right inguinal regions. The nodules were characterized as mixed, fibroblastic, verrucous and occult types of sarcoid. Histologically there was proliferation of dermal fibroblasts, with or without pseudoepitheliomatous hyperplasia of the epidermis (frequently ulcerated), and formation of small isolated groups of neoplastic fibroblasts in the superficial dermis. Three tissue samples were submitted to DNA extraction and PCR amplification with generic primers for the internal region of the papillomavirus L1 gene. The amplified products from two samples were sequenced and showed 99% identity with the bovine papillomavirus (BPV) BR-UEL-4. This is the first description of BPV BR-UEL-4 infecting a horse and causing sarcoid in this species. BPV BR-UEL-4 is a putative new BPV type recently identified in skin papillomas in a Brazilian cattle herd.

Um equino, sem raça definida, macho com três anos de idade apresentou múltiplos nódulos na pele, em diversas regiões do corpo. As lesões localizavam-se predominantemente nos lábios, nas bochechas, na região submandibular e na região inguinal direita. Os tumores caracterizavam-se como sarcoides dos tipos misto, fibroblástico, verrucoso e oculto. Histologicamente apresentaram proliferação de fibroblastos dérmicos, muitas vezes ulcerado, com ou sem hiperplasia pseudoepiteliomatosa da epiderme e formação de pequenos grupos isolados de fibroblastos neoplásicos na derme superficial. Três amostras de tecido foram submetidas à extração de DNA e amplificação por PCR com oligonucleotídeos iniciadores genéricos direcionados para uma região interna do gene L1 dos papilomavírus. Os produtos resultantes da amplificação de duas amostras foram sequenciados e demonstraram identidade de 99% com o papilomavírus bovino (BPV) BR-UEL-4. Essa é a primeira descrição da infecção de equinos, bem como de sua associação com sarcoide pelo BPV BR-UEL-4, um suposto novo tipo de BPV identificado recentemente no Brasil a partir de papilomas cutâneos em bovinos.

Linfossarcoma de células B multicêntrico em uma ovelha

Background:  :  : Lymphosarcoma is a malignant tumor from tumoral cells similar to lymphocytes and its spontaneous development in small ruminants is unusual in Brazil. In cattle, the lymphosarcomas are often associated with infection by bovine leukemia virus (BLV), although sheep are considered as a very susceptible specie to BLV. Spontaneously lymphosarcoma is rare and in most cases it is observed in apparently healthy animals in slaughterhouses. There is no report of this tumor in sheep in southern Brazil. We describe a case of spontaneous multicentric B-cells lymphosarcoma in an ewe. Case: In June 2007, a 4-years-old mixed breed ewe was necropsied after clinical signs as anorexia, weight loss and death in few weeks. This ewe was purchased in September 2006 with another 44 sheep, most females of the same age. Dairy cattle were also raised together with sheep at the same farm. Fragments of liver, lung, spleen, kidneys, brain and parotid lymph node were sent to the Veterinary Pathology Laboratory - Universidade Federal de Santa Maria, Brazil, for histopathological evaluation. Multiply white to yellow nodules, with 0.5 to 2 cm of diameter, were observed in the liver, kidneys, and the parotid lymph node. The nodules were soft and some coalesced and infiltrating the hepatic parenchyma. The kidneys nodules were similar to those of the liver but prominent in the capsule. They were o

Linfossarcoma de células B multicêntrico em uma ovelha

Background:  :  : Lymphosarcoma is a malignant tumor from tumoral cells similar to lymphocytes and its spontaneous development in small ruminants is unusual in Brazil. In cattle, the lymphosarcomas are often associated with infection by bovine leukemia virus (BLV), although sheep are considered as a very susceptible specie to BLV. Spontaneously lymphosarcoma is rare and in most cases it is observed in apparently healthy animals in slaughterhouses. There is no report of this tumor in sheep in southern Brazil. We describe a case of spontaneous multicentric B-cells lymphosarcoma in an ewe. Case: In June 2007, a 4-years-old mixed breed ewe was necropsied after clinical signs as anorexia, weight loss and death in few weeks. This ewe was purchased in September 2006 with another 44 sheep, most females of the same age. Dairy cattle were also raised together with sheep at the same farm. Fragments of liver, lung, spleen, kidneys, brain and parotid lymph node were sent to the Veterinary Pathology Laboratory - Universidade Federal de Santa Maria, Brazil, for histopathological evaluation. Multiply white to yellow nodules, with 0.5 to 2 cm of diameter, were observed in the liver, kidneys, and the parotid lymph node. The nodules were soft and some coalesced and infiltrating the hepatic parenchyma. The kidneys nodules were similar to those of the liver but prominent in the capsule. They were o

Multiple congenital abnormalities in newborn domestic kittens / Anomalias congênitas múltiplas em felinos domésticos neonatos

Background: Congenital defects and diseases have hereditary or acquired etiology that affects domestic and wildlife animals, and humans. These anomalies are usually isolated and their location and intensity determine the survival of affected animals. Congenital malformations in domestic cats are less frequent than in dogs. Although some racial groups of cats seem to present greater predisposition to develop certain types of congenital defects and / or hereditary diseases, such information is controversial and has been discussed in several reports. Some malformations are rare in cats and poorly reported in Brazil and when they occur, mostly, are not identifi ed or the etiology is unknown.Case: This report describes the clinicopathological features of three newborn Persian kittens of the same dam. They were examined soon after birth because had multiple congenital malformations that involved the oral and nasal cavities, limbs, eyes, abdominal cavity and the vertebrae. The abnormalities were characterized by hyperextension in limbs and palatosquisis (Kittens 1, 2, and 3), unilateral and bilateral clinical anophthalmia (Kittens 1 and 3, respectively), unilateral cheiloschisis (Kittens 2), kyphosis, and abdominosquisis (1). At necropsy the Kitten 1 showed in the right eye socket rudiments of the eye covered with skin, and failure in the lining of the hard palate with bilateral hypop

Background: Congenital defects and diseases have hereditary or acquired etiology that affects domestic and wildlife animals, and humans. These anomalies are usually isolated and their location and intensity determine the survival of affected animals. Congenital malformations in domestic cats are less frequent than in dogs. Although some racial groups of cats seem to present greater predisposition to develop certain types of congenital defects and / or hereditary diseases, such information is controversial and has been discussed in several reports. Some malformations are rare in cats and poorly reported in Brazil and when they occur, mostly, are not identifi ed or the etiology is unknown.Case: This report describes the clinicopathological features of three newborn Persian kittens of the same dam. They were examined soon after birth because had multiple congenital malformations that involved the oral and nasal cavities, limbs, eyes, abdominal cavity and the vertebrae. The abnormalities were characterized by hyperextension in limbs and palatosquisis (Kittens 1, 2, and 3), unilateral and bilateral clinical anophthalmia (Kittens 1 and 3, respectively), unilateral cheiloschisis (Kittens 2), kyphosis, and abdominosquisis (1). At necropsy the Kitten 1 showed in the right eye socket rudiments of the eye covered with skin, and failure in the lining of the hard palate with bilateral hypop

Anaplastic ventricular adenocarcinoma in a blue and gold Macaw (Ara ararauna)

A case of anaplastic ventricular adenocarcinoma in an adult, female captive blue and gold macaw (Ara ararauna) is reported. The bird died suddenly and was submitted to necropsy. The carcass was in poor body condition. A pale, firm neoplastic mass was observed infiltrating the wall of the proventricular-ventricular junction. Histologically, the neoplasm consisted of a poorly demarcated and highly invasive proliferation of cuboidal to columnar neoplastic epithelial cells arranged into small groups and admixed with a dense desmoplastic reaction. Numerous neoplastic cells showed a finely fibrillar, Alcian blue-positive cytoplasmic material. Neoplastic cells were strongly positive for pancytokeratin and negative for vimentin. The diagnosis of anaplastic ventricular adenocarcinoma was based on histological, histochemical, and immunohistochemical findings. These neoplasms are uncommon in psittacine birds and to the best of our knowledge have not been reported in this species.