Renal dysplasia in dogs: retrospective study (2008-2013) / Displasia renal em cães: estudo retrospectivo (2008-2013)

Background: Renal dysplasia, which has been reported in some dogs and human patients, refers to a developmental disorder of renal parenchyma due to imperfect inductive interaction between the mesonephric duct and the metanephric blastemal. In dogs, the characteristic histological findings on which diagnosis is based include (1) persistent metanephric ducts surrounded by primitive mesenchyme, (2) fetal or immature glomeruli, (3) fetal or immature tubules, and (4) anomalous presence of interstitial fibrous tissue. The aim of this study was to report the major pathological and immunohistochemical features of nine young dogs necropsied with renal dysplasia.Cases: The necropsy files from the Laboratório de Patologia Veterinária (LPV) of the Universidade Federal do Mato Grosso (UFMT) were reviewed between the years 2008 and 2013. Dogs diagnosed with chronic kidney failure and macroscopic and histopathological renal lesions consistent with renal dysplasia were selected. Kidney fragments in paraffin blocks were cut and stained with hematoxylin and eosin and by immunohistochemistry (IHC) using anti-vimentin and anti-cytokeratin monoclonal antibodies. The staining was considered positive for the presence of at least one renal cell marked with brown cytoplasmic staining clear and unambiguous. A total of 787 necropsies of dogs were performed. Of these, 64 had a clinical diagnosis of [...]

Renal dysplasia in dogs: retrospective study (2008-2013) / Displasia renal em cães: estudo retrospectivo (2008-2013)

Background: Renal dysplasia, which has been reported in some dogs and human patients, refers to a developmental disorder of renal parenchyma due to imperfect inductive interaction between the mesonephric duct and the metanephric blastemal. In dogs, the characteristic histological findings on which diagnosis is based include (1) persistent metanephric ducts surrounded by primitive mesenchyme, (2) fetal or immature glomeruli, (3) fetal or immature tubules, and (4) anomalous presence of interstitial fibrous tissue. The aim of this study was to report the major pathological and immunohistochemical features of nine young dogs necropsied with renal dysplasia.Cases: The necropsy files from the Laboratório de Patologia Veterinária (LPV) of the Universidade Federal do Mato Grosso (UFMT) were reviewed between the years 2008 and 2013. Dogs diagnosed with chronic kidney failure and macroscopic and histopathological renal lesions consistent with renal dysplasia were selected. Kidney fragments in paraffin blocks were cut and stained with hematoxylin and eosin and by immunohistochemistry (IHC) using anti-vimentin and anti-cytokeratin monoclonal antibodies. The staining was considered positive for the presence of at least one renal cell marked with brown cytoplasmic staining clear and unambiguous. A total of 787 necropsies of dogs were performed. Of these, 64 had a clinical diagnosis of [...](AU)

Ovarian and uterine horn agenesis accompanied by ectopic fetal mummification in canine / Agenesia ovariana e de corno uterino acompanhada por mumificação fetal ectópica em canino

Background: The uterine horn agenesis or aplasia is a rare anomaly consisting of absence or incomplete development of the paramesonephric ducts that origin the uterine horns. This change occurs during fetal formation and may occur concomitantly to agenesis of the ovary and/or ipsilateral kidney. The extra-uterine pregnancy consists of fetal growth outside the uterine cavity and can occur as a tubal or abdominal pregnancy. We report here the case of a 7-years-old mix breed dog, attended at the Veterinary Hospital of the Federal University of Mato Grosso, with accidental diagnosis of agenesis of uterine horn and ovaries and ectopic fetal mummification. Case: A 7-years-old mix breed dog, not spayed, was attended at the Veterinary Hospital of the Federal University of Mato Grosso (HOVET-UFMT), complaining of mucous bloody vaginal discharge. The patient had regular estrus and was multiparous. There was no mating history in the last estrus neither trauma over the past months. In previous pregnancies the patient presented eutocic labors. On physical examination the dog showed apathy although it was alert, pale mucous membranes, presence of perivulvar blackish secretion and discreet abdominal enlargement. As preoperative exams, a complete blood count, liver and renal function (serum creatinine and alanine aminotransferase) were performed. It has also performed the abdominal ultrasound [...]

Ovarian and uterine horn agenesis accompanied by ectopic fetal mummification in canine / Agenesia ovariana e de corno uterino acompanhada por mumificação fetal ectópica em canino

Background: The uterine horn agenesis or aplasia is a rare anomaly consisting of absence or incomplete development of the paramesonephric ducts that origin the uterine horns. This change occurs during fetal formation and may occur concomitantly to agenesis of the ovary and/or ipsilateral kidney. The extra-uterine pregnancy consists of fetal growth outside the uterine cavity and can occur as a tubal or abdominal pregnancy. We report here the case of a 7-years-old mix breed dog, attended at the Veterinary Hospital of the Federal University of Mato Grosso, with accidental diagnosis of agenesis of uterine horn and ovaries and ectopic fetal mummification. Case: A 7-years-old mix breed dog, not spayed, was attended at the Veterinary Hospital of the Federal University of Mato Grosso (HOVET-UFMT), complaining of mucous bloody vaginal discharge. The patient had regular estrus and was multiparous. There was no mating history in the last estrus neither trauma over the past months. In previous pregnancies the patient presented eutocic labors. On physical examination the dog showed apathy although it was alert, pale mucous membranes, presence of perivulvar blackish secretion and discreet abdominal enlargement. As preoperative exams, a complete blood count, liver and renal function (serum creatinine and alanine aminotransferase) were performed. It has also performed the abdominal ultrasound [...](AU)

Hemangiosarcoma in a free-living Rufous-bellied Thrush (Turdus rufiventris)

Background: Hemangiosarcoma is a malignant endothelial cell-derived neoplasm characterized by an intense cellular proliferation organized in a solid or cavernous pattern. Is characterized by intense cell proliferation, and organized in vascular slits, filled with blood, with fast grow and there is a high recurrence rate. This paper reports a case of multiple hemangiosarcoma in a Rufous-bellied Thrush (Turdus rufiventris). Case: A free-living Rufous-bellied Thrush (Turdus rufiventris), was attended at the veterinary hospital of the Federal University of Mato Grosso (UFMT) - Cuiabá, presenting prostration and three masses located in the following regions: left periorbital area, left lateral insertion of the beak and distal portion of the left tibia. The masses were blackened colored with an irregular aspect, and the cut surface was multiple cavity, filled with a blackened gelatinous material. The animal died during the surgical procedure and was sent to necropsy. Additionally, special immunohistochemistry staining was used in the tumors sections, with primary anti-S-100, anti-Von Willebrand Factor, anti-desmin, anti-actin, anti-cytokeratin and anti-vimentin. The three masses have rounded shape, multilobuled surface, deep red to blackened color, with skin adhered base, and, when cut, blackened color with multiple cavities filled with red to blackened gelatinous material and [...]

Partial unilateral radial hemimelia in feline / Hemimelia parcial unilateral de rádio em felino

Background: Hemimelia is a rare anomaly in which one of paired bone is congenital or partially absent. The etiology may be related to genetic and/or environmental factors. Clinically is observed the angulation of the affected limb, resulting in functional limitations as angular deformity, lameness and decreased range of motion. The diagnosis is based on clinical findings and radiographic examination that detects the complete or partial absence of the affected bone and angular deviations. We aim to report a case of a partial unilateral radial hemimelia in a feline diagnosed at the Veterinary Hospital of the Federal University of Mato Grosso (HOVET-UFMT). Case: We attended at the HOVET-UFMT a two years old, feline, female, domestic short hair, presenting as a complaint the presence of a friable mass in the oral cavity for a year and a deformity in the left forelimb since birth, showing swallowing difficulties, lameness and difficulty support. On clinical examination, we obeserved the left forelimb flexed and deviation in the medial direction, shortening of the limb, no crepitation during handling and evident lameness. Radiographic examination in the craniocaudal and mediolateral projections of the thoracic limbs revealed the partial absence of the radius with just a trace of the proximal radial epiphysis, shortening and a marked ulnar curvature, producing a significant deviation [...]

Hemangiosarcoma in a free-living Rufous-bellied Thrush (Turdus rufiventris)

Background: Hemangiosarcoma is a malignant endothelial cell-derived neoplasm characterized by an intense cellular proliferation organized in a solid or cavernous pattern. Is characterized by intense cell proliferation, and organized in vascular slits, filled with blood, with fast grow and there is a high recurrence rate. This paper reports a case of multiple hemangiosarcoma in a Rufous-bellied Thrush (Turdus rufiventris). Case: A free-living Rufous-bellied Thrush (Turdus rufiventris), was attended at the veterinary hospital of the Federal University of Mato Grosso (UFMT) - Cuiabá, presenting prostration and three masses located in the following regions: left periorbital area, left lateral insertion of the beak and distal portion of the left tibia. The masses were blackened colored with an irregular aspect, and the cut surface was multiple cavity, filled with a blackened gelatinous material. The animal died during the surgical procedure and was sent to necropsy. Additionally, special immunohistochemistry staining was used in the tumors sections, with primary anti-S-100, anti-Von Willebrand Factor, anti-desmin, anti-actin, anti-cytokeratin and anti-vimentin. The three masses have rounded shape, multilobuled surface, deep red to blackened color, with skin adhered base, and, when cut, blackened color with multiple cavities filled with red to blackened gelatinous material and [...](AU)

Partial unilateral radial hemimelia in feline / Hemimelia parcial unilateral de rádio em felino

Background: Hemimelia is a rare anomaly in which one of paired bone is congenital or partially absent. The etiology may be related to genetic and/or environmental factors. Clinically is observed the angulation of the affected limb, resulting in functional limitations as angular deformity, lameness and decreased range of motion. The diagnosis is based on clinical findings and radiographic examination that detects the complete or partial absence of the affected bone and angular deviations. We aim to report a case of a partial unilateral radial hemimelia in a feline diagnosed at the Veterinary Hospital of the Federal University of Mato Grosso (HOVET-UFMT). Case: We attended at the HOVET-UFMT a two years old, feline, female, domestic short hair, presenting as a complaint the presence of a friable mass in the oral cavity for a year and a deformity in the left forelimb since birth, showing swallowing difficulties, lameness and difficulty support. On clinical examination, we obeserved the left forelimb flexed and deviation in the medial direction, shortening of the limb, no crepitation during handling and evident lameness. Radiographic examination in the craniocaudal and mediolateral projections of the thoracic limbs revealed the partial absence of the radius with just a trace of the proximal radial epiphysis, shortening and a marked ulnar curvature, producing a significant deviation [...](AU)

Pythium insidiosum colitis in a dog: treatment and clinical outcome / Colite por Pythium insidiosum em um cão: tratamento e evolução clínica

The aim of this report is to describe the clinical, pathological and imaging findings and treatment of colitis caused by Pythium insidiosum in a canine presenting haematochezia and progressive weight loss. Through imaging, a thickening of the transverse and descending colon was observed. Histopathological analysis of the large intestine fragment revealed the presence of hyphae, confirmed by immunohistochemistry and PCR as P. insidiosum. Antifungal treatment with itraconazole implemented after partial surgical resection, resulted in control of the disease.(AU)

O objetivo deste relato é descrever os achados clínico-patológicos, de imagem e o tratamento de colite por Pythium insidiosum em canino apresentando hematoquezia e emagrecimento progressivo. Nos exames de imagem, foram observados espessamento do cólon transverso e descendente. Análise histopatológica de fragmento do intestino grosso revelou a presença de hifas, confirmado pela imuno-histoquímica e PCR como P. insidiosum. Terapia antifúngica com itraconazol foi instituída pós-ressecção cirúrgica parcial, obtendo-se controle da doença.(AU)

Schwannoma maligno cutâneo em canino / ienne

As neoplasias primárias de nervos periféricos apresentam-se com pouca frequência em pequenos animais, sendo de aproximadamente 0,5% a incidência de tumores neurais benignos e malignos em cães. O presente trabalho tem por objetivo relatar o caso de uma fêmea canina, sem raça definida, de grande porte e onze anos de idade, atendida no Hospital Veterinário da Universidade Federal de Mato Grosso (HOVET-UFMT), apresentando neoformação em região torácica com evolução de dez meses. O nódulo media aproximadamente cinco centímetros de diâmetro, apresentava-se aderido ao subcutâneo, de formato regular e consistência firme. Ao exame clínico, não foram observadas dor à palpação ou ulceração cutânea. Após a realização dos exames pré-cirúrgicos hematológicos e de imagem (radiografia torácica), sem alterações significativas; a paciente foi encaminhada para a exérese da neoformação. Perante avaliação histopatológica, foi observada massa circunscrita por cápsula de tecido conjuntivo e células dispostas em múltiplos padrões regulares, ocasionalmente, em redemoinhos. Proliferação de células neoplásicas com moderado pleomorfismo celular, núcleo eosinofílico redondo a ovalado, nucléolo fortemente basofílico e citoplasma abundante, por vezes alongado. Anisocariose eanisocitose evidentes, além de figuras bizarras. Observou-se também a presença de infiltrado inflamatório mononuclear multifocal. Sendo assim, o diagnóstico conclusivo foi o de tumor de bainha de nervo periférico maligno (Schwannoma maligno). O procedimento cirúrgico para a extirpação da neoplasia foi realizado respeitando amplas margens de segurança. Por este motivo, mostrou-se eficaz, pois o paciente não apresentou recidivas locais, tampouco metástases a distancia em um período de 26 meses

The primary neoplasms of peripheral nerves present with low frequency in small animals, and from about 0.5 % to neural incidence of benign and malignant tumors in dogs. Herein we report one case of a large female mongrel dog, it was eleven years old, attended at the Veterinary Hospital of the Federal University of Mato Grosso (HOVET-UFMT), with formation in the thoracic region with 10 months evolution. The nodule measuring approximately five centimeters in diameter, it was attached to the subcutaneous, regular format and firm consistency. On clinical examination, there were no pain on palpation and cutaneous ulceration. After completion of hematological pre-surgical and imaging tests (thoracic radiography), with no significant change;the patient was referred to the removal of the neoformation. Before histopathological evaluation, mass was observed circumscribed by connective tissue capsule and cells arranged in multiple regular patterns occasionally in swirls. Proliferation of neoplastic cells with moderate cellular pleomorphism, eosinophilic core round to oval,strongly basophilic nucleoli and abundant cytoplasm, sometimes elongated. It presents anisocariose and obvious anisocytosis with bizarre figures. Also noted it is the presence of multifocal mononuclear inflammatory infiltrate.Thus, the conclusive diagnosis was that of a malignant peripheral nerve sheath tumor (malignant schwannoma).The surgical procedure for removal of the tumor was carried out respecting ample safety margins. For this reason, it was effective because the patient did not present local recurrence, metastases either the distance over a period of 26 months

Schwannoma maligno cutâneo em canino / ienne

As neoplasias primárias de nervos periféricos apresentam-se com pouca frequência em pequenos animais, sendo de aproximadamente 0,5% a incidência de tumores neurais benignos e malignos em cães. O presente trabalho tem por objetivo relatar o caso de uma fêmea canina, sem raça definida, de grande porte e onze anos de idade, atendida no Hospital Veterinário da Universidade Federal de Mato Grosso (HOVET-UFMT), apresentando neoformação em região torácica com evolução de dez meses. O nódulo media aproximadamente cinco centímetros de diâmetro, apresentava-se aderido ao subcutâneo, de formato regular e consistência firme. Ao exame clínico, não foram observadas dor à palpação ou ulceração cutânea. Após a realização dos exames pré-cirúrgicos hematológicos e de imagem (radiografia torácica), sem alterações significativas; a paciente foi encaminhada para a exérese da neoformação. Perante avaliação histopatológica, foi observada massa circunscrita por cápsula de tecido conjuntivo e células dispostas em múltiplos padrões regulares, ocasionalmente, em redemoinhos. Proliferação de células neoplásicas com moderado pleomorfismo celular, núcleo eosinofílico redondo a ovalado, nucléolo fortemente basofílico e citoplasma abundante, por vezes alongado. Anisocariose eanisocitose evidentes, além de figuras bizarras. Observou-se também a presença de infiltrado inflamatório mononuclear multifocal. Sendo assim, o diagnóstico conclusivo foi o de tumor de bainha de nervo periférico maligno (Schwannoma maligno). O procedimento cirúrgico para a extirpação da neoplasia foi realizado respeitando amplas margens de segurança. Por este motivo, mostrou-se eficaz, pois o paciente não apresentou recidivas locais, tampouco metástases a distancia em um período de 26 meses(AU)

The primary neoplasms of peripheral nerves present with low frequency in small animals, and from about 0.5 % to neural incidence of benign and malignant tumors in dogs. Herein we report one case of a large female mongrel dog, it was eleven years old, attended at the Veterinary Hospital of the Federal University of Mato Grosso (HOVET-UFMT), with formation in the thoracic region with 10 months evolution. The nodule measuring approximately five centimeters in diameter, it was attached to the subcutaneous, regular format and firm consistency. On clinical examination, there were no pain on palpation and cutaneous ulceration. After completion of hematological pre-surgical and imaging tests (thoracic radiography), with no significant change;the patient was referred to the removal of the neoformation. Before histopathological evaluation, mass was observed circumscribed by connective tissue capsule and cells arranged in multiple regular patterns occasionally in swirls. Proliferation of neoplastic cells with moderate cellular pleomorphism, eosinophilic core round to oval,strongly basophilic nucleoli and abundant cytoplasm, sometimes elongated. It presents anisocariose and obvious anisocytosis with bizarre figures. Also noted it is the presence of multifocal mononuclear inflammatory infiltrate.Thus, the conclusive diagnosis was that of a malignant peripheral nerve sheath tumor (malignant schwannoma).The surgical procedure for removal of the tumor was carried out respecting ample safety margins. For this reason, it was effective because the patient did not present local recurrence, metastases either the distance over a period of 26 months(AU)

Displasia folicular do pelo preto em canino / Black hair follicular dysplasia in canine

A displasia folicular do pelo preto (DFPP) é um distúrbio genético e raro onde os cães compelagens bi ou tricolor perdem seus pelos apenas nas áreas de pelos pretos, em idade precoce, sem predileçãoracial e sexual. É um distúrbio familiar sem tratamento atualmente, onde são caracterizadas por aglomerados demelanina nos pelos, acúmulo de melanossomas nos melanócitos (macromelanossomas) e insuficientetransferência de melanina para os queratinócitos adjacentes. Este trabalho tem como objetivo relatar um casoatendido no Hospital Veterinário da Universidade Federal do Mato Grosso (HOVET-UFMT), em uma cadela daraça Basset Hound, apresentando queda de pelo nas regiões de pelos pretos, descamação, vesículas, pápulas eprurido leve. Através do histórico, achados clínicos, associados ao tricograma e histopatologia, foi estabelecido odiagnóstico de DFPP. Não existe tratamento específico para esta dermatopatia, entretanto, a melhora do quadroclínico pode ser observada com o tratamento paliativo

The black hair follicular dysplasia in canine (BHFD) is a genetic and rare disorder where dogswith coats bi or tri lose their hair only in the areas of the black-hair at an early age, without racial and sexualpredilection. It is a family disorder with no current treatment, which are characterized by clusters of melanin inthe hair, melanosomes accumulation in the melanocyte (macromelanosomas) and insufficient melanin transfer tothe adjacent keratinocytes. This study aims to report a case treated at the Veterinary Hospital of the FederalUniversity of Mato Grosso (HOVET-UFMT), a bitch of the race Basset Hound, showing a drop of at the regionsof the black-hair, peeling, blistering, papules and mild itching. Through history, clinical findings, associated withtrichografy and histopathology, was established the diagnosis of BHFD. There is no specific treatment for thisskin disease, however, the clinical picture of the improvement can be observed with the palliative treatment

Clinical, surgical, histological and urinary aspects in six dogs with total penectomy / Aspectos clínicos, cirúrgicos, histológicos e urinários de seis cães submetidos à penectomia total

Background: In dogs, penectomy followed by uretrostomy has been little reported in the veterinary literature. These surgical procedures are indicated in cases of penile trauma and/or neoplasms as well in scrotal and preputial neoplasms. After uretrostomias is commonly observed bleeding site by approximately 4.2 days. However, studies reporting the incidence of UTI in the postoperative period of dogs submitted to penectomy, followed by scrotal urethrostomy have never been evaluated. Thus, the aim was report the evolution of dogs operated by this technique, theirs complications and the histological results, urinalysis and uroculture in patients with 60 days post-operative. Case: In the study period of 17 months (March 2013 to July 2014), nine dogs showed various neoplastic diseases involving the penis, prepuce, scrotum and testicles. In nine selected dogs to the study, only six were considered due to patient death before the minimum period used for postoperative evaluation. After surgery, the genital tract along the resected neoformation were conditioned to 10% formalin and sent to the Veterinary Pathology Laboratory for tissue analysis in light microscopy. All patients remained in hospital in the postoperative period about a week, receiving medications intravenously, execution of dressing every 12 h and evaluation of possible postoperative complications such as dehiscence suture...(AU)

Displasia folicular do pelo preto em canino / Black hair follicular dysplasia in canine

A displasia folicular do pelo preto (DFPP) é um distúrbio genético e raro onde os cães compelagens bi ou tricolor perdem seus pelos apenas nas áreas de pelos pretos, em idade precoce, sem predileçãoracial e sexual. É um distúrbio familiar sem tratamento atualmente, onde são caracterizadas por aglomerados demelanina nos pelos, acúmulo de melanossomas nos melanócitos (macromelanossomas) e insuficientetransferência de melanina para os queratinócitos adjacentes. Este trabalho tem como objetivo relatar um casoatendido no Hospital Veterinário da Universidade Federal do Mato Grosso (HOVET-UFMT), em uma cadela daraça Basset Hound, apresentando queda de pelo nas regiões de pelos pretos, descamação, vesículas, pápulas eprurido leve. Através do histórico, achados clínicos, associados ao tricograma e histopatologia, foi estabelecido odiagnóstico de DFPP. Não existe tratamento específico para esta dermatopatia, entretanto, a melhora do quadroclínico pode ser observada com o tratamento paliativo(AU)

The black hair follicular dysplasia in canine (BHFD) is a genetic and rare disorder where dogswith coats bi or tri lose their hair only in the areas of the black-hair at an early age, without racial and sexualpredilection. It is a family disorder with no current treatment, which are characterized by clusters of melanin inthe hair, melanosomes accumulation in the melanocyte (macromelanosomas) and insufficient melanin transfer tothe adjacent keratinocytes. This study aims to report a case treated at the Veterinary Hospital of the FederalUniversity of Mato Grosso (HOVET-UFMT), a bitch of the race Basset Hound, showing a drop of at the regionsof the black-hair, peeling, blistering, papules and mild itching. Through history, clinical findings, associated withtrichografy and histopathology, was established the diagnosis of BHFD. There is no specific treatment for thisskin disease, however, the clinical picture of the improvement can be observed with the palliative treatment(AU)

Clinical, surgical, histological and urinary aspects in six dogs with total penectomy / Aspectos clínicos, cirúrgicos, histológicos e urinários de seis cães submetidos à penectomia total

Background: In dogs, penectomy followed by uretrostomy has been little reported in the veterinary literature. These surgical procedures are indicated in cases of penile trauma and/or neoplasms as well in scrotal and preputial neoplasms. After uretrostomias is commonly observed bleeding site by approximately 4.2 days. However, studies reporting the incidence of UTI in the postoperative period of dogs submitted to penectomy, followed by scrotal urethrostomy have never been evaluated. Thus, the aim was report the evolution of dogs operated by this technique, theirs complications and the histological results, urinalysis and uroculture in patients with 60 days post-operative. Case: In the study period of 17 months (March 2013 to July 2014), nine dogs showed various neoplastic diseases involving the penis, prepuce, scrotum and testicles. In nine selected dogs to the study, only six were considered due to patient death before the minimum period used for postoperative evaluation. After surgery, the genital tract along the resected neoformation were conditioned to 10% formalin and sent to the Veterinary Pathology Laboratory for tissue analysis in light microscopy. All patients remained in hospital in the postoperative period about a week, receiving medications intravenously, execution of dressing every 12 h and evaluation of possible postoperative complications such as dehiscence suture...

Skin biopsies retrospective study: a comparison of canine atopic dermatitis and other dermatoses / Estudo retrospectivo de biópsias de pele: um comparativo da dermatite atópica canina com as demais dermatoses

Canine atopic dermatitis (CAD) is a genetic disease which promotes malfunction of the epidermal barrier and allergic sensitization by environmental allergens. Several breeds in ages ranging from one to 3 years are predisposed. The diagnosis demands time, once CAD should be differentiated from other pruritic diseases, therefore the aim of the retrospective study to assess canine cases submitted to skin biopsies, and associate clinical and laboratory findings of the cases of CAD with other non-neoplastic dermatoses. Of the fifty-two biopsies performed, 11 dogs were diagnosed with CAD, 12 without CAD and 29 with neoplastic diseases. Pruritus was described in all atopic dogs and the onset age was 4.4 years. The dermatophytosis and Staphylococcus sp. and/or Malassezia sp. Infection were the most frequent diseases related in cases of CAD. Skin biopsy is a diagnostic tool that in association with clinical and epidemiological findings supports the DAC diagnosis, improving the quality of life of atopic dogs and their owners.

A Dermatite Atópica Canina (DAC) é uma doença de fundo genético que promove deficiência no funcionamento da barreira epidérmica e sensibilização alérgica do indivíduo a alérgenos ambientais. Encontram-se predispostos cães de várias raças e com idade média de um e três anos. O diagnóstico exige tempo, pois a DAC deve ser excluída das doenças pruriginosas, sendo assim o presente trabalho teve como objetivo realizar estudo retrospectivo dos casos de cães submetidos a biópsias de pele, e associar os achados clínicos e laboratoriais dos casos de DAC com as demais dermatoses não neoplásicas. Cinquenta e duas biópsias de pele foram realizadas, sendo 11 de cães com DAC, 14 (26,92%) sem DAC e 27 (51,92%) com doenças neoplásicas. O prurido foi observado em todos os cães atópicos e a idade de surgimento dos sinais foi de 4,4 anos. A dermatofitose e a infecção por Staphylococcus sp. e /ou Malassezia sp. foram as doenças mais frequentes nos casos de DAC. A biopsia é mais um recurso diagnóstico, que somado aos achados clínico-epidemiológicos auxilia na confirmação da DAC, melhorando a qualidade de vida dos cães portadores da doença e dos seus proprietários.

Skin biopsies retrospective study: a comparison of canine atopic dermatitis and other dermatoses / Estudo retrospectivo de biópsias de pele: um comparativo da dermatite atópica canina com as demais dermatoses

Canine atopic dermatitis (CAD) is a genetic disease which promotes malfunction of the epidermal barrier and allergic sensitization by environmental allergens. Several breeds in ages ranging from one to 3 years are predisposed. The diagnosis demands time, once CAD should be differentiated from other pruritic diseases, therefore the aim of the retrospective study to assess canine cases submitted to skin biopsies, and associate clinical and laboratory findings of the cases of CAD with other non-neoplastic dermatoses. Of the fifty-two biopsies performed, 11 dogs were diagnosed with CAD, 12 without CAD and 29 with neoplastic diseases. Pruritus was described in all atopic dogs and the onset age was 4.4 years. The dermatophytosis and Staphylococcus sp. and/or Malassezia sp. Infection were the most frequent diseases related in cases of CAD. Skin biopsy is a diagnostic tool that in association with clinical and epidemiological findings supports the DAC diagnosis, improving the quality of life of atopic dogs and their owners.(AU)

A Dermatite Atópica Canina (DAC) é uma doença de fundo genético que promove deficiência no funcionamento da barreira epidérmica e sensibilização alérgica do indivíduo a alérgenos ambientais. Encontram-se predispostos cães de várias raças e com idade média de um e três anos. O diagnóstico exige tempo, pois a DAC deve ser excluída das doenças pruriginosas, sendo assim o presente trabalho teve como objetivo realizar estudo retrospectivo dos casos de cães submetidos a biópsias de pele, e associar os achados clínicos e laboratoriais dos casos de DAC com as demais dermatoses não neoplásicas. Cinquenta e duas biópsias de pele foram realizadas, sendo 11 de cães com DAC, 14 (26,92%) sem DAC e 27 (51,92%) com doenças neoplásicas. O prurido foi observado em todos os cães atópicos e a idade de surgimento dos sinais foi de 4,4 anos. A dermatofitose e a infecção por Staphylococcus sp. e /ou Malassezia sp. foram as doenças mais frequentes nos casos de DAC. A biopsia é mais um recurso diagnóstico, que somado aos achados clínico-epidemiológicos auxilia na confirmação da DAC, melhorando a qualidade de vida dos cães portadores da doença e dos seus proprietários.(AU)

Ocurrence of anti-Toxoplasma gondii and Ehrlichia canis antibodies in dogs with nervous alterations assisted at a veterinary teaching hospital / Ocorrência de anticorpos anti-Toxoplasma gondii e Ehrlichia canis em cães com alterações nervosas atendidos em hospital veterinário universitário

Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii. Most often, the disease is asymptomatic in dogs due to effectiveness of the immune system. By the way, numerous clinical signs can be triggered, including neuromuscular like ataxia, circling, behavioral changes, seizures, spasms and tremors. The disease usually manifests itself after immune depression, and, for this reason, usually may be associated to immunosuppressive infections, like by distemper virus and Ehrlichia canis. E. canis is an obligatory intracellular rickettsia of mature or immature hematopoietic cells and canine monocytes, and the etiologic agent of Canine Monocytic Ehrlichiosis (CME). Like toxoplasmosis, CME may cause nervous signs as well. This study aims to estimate the occurrence of anti- T. gondii and anti- E. canis antibodies and characterize nervous syndromes in dogs with nervous alterations assisted at a veterinary teaching hospital. From May 2010 to December 2011, dogs with nervous alterations assisted at HOVET-UFMT were submitted to neurological evaluation for determining nervous syndromes. Serum and whole blood samples were collected for performing indirect immunofluorescence test (IFAT) for T. gondii and E. canis and hematological evaluation. Prevalence of 10,3 and 94,8% were observed for T. gondii and E. canis, respectively. The most frequent syndrome was multifocal, occurring in 53,5% of the cases, followed by spinal cord alterations in 22,4%, cerebral alterations in 10,3%, paroxysmalsyndrome in 10,3% and neuropathic syndrome in 3,5% of the cases. There was no statistical significancebetween the variables analyzed (titration to T. gondii, E. canis and nervous syndromes). In conclusion,the occurrence of coinfection with T. gondii and E. canis may contribute to toxoplasmosis clinicalmanifestation, due to opportunist character of the parasite in order to the establishment of disease.(AU)

 A toxoplasmose é uma zoonose causada por Toxoplasma gondii. Em cães é na maioria das vezes assintomática em decorrência da efetividade do sistema imunológico. Entretanto, em alguns casos pode desencadear inúmeros sinais clínicos, incluindo comprometimento neuromuscular, sendo os sinais mais descritos ataxia, andar em círculos, alterações de comportamento, convulsões, espasmos e tremores. A toxoplasmose geralmente manifesta-se após imunodepressão e por isso, frequentemente pode estar associada a infecções imunossupressoras como as causadas pelo vírus da cinomose e Ehrlichia canis. E. canis é uma rickettsia intracelular obrigatória de células hematopoiéticas maduras ou imaturas e de monócitos caninos, agente etiológico da Erliquiose Monocítica Canina (EMC). Assim como a toxoplasmose, a EMC também pode ocasionar sinais nervosos. Este estudo tem o objetivo de estimar a prevalência de anticorpos contra T. gondii e E. canis e caracterizar as respectivas síndromes clínicas em cães com sinais nervosos atendidos em um hospital veterinário. Entre maio de 2010 a dezembro de 2011, cães com sinais nervosos atendidos no HOVET-UFMT foram submetidos a exame neurológico para determinação das síndromes nervosas. Amostras de soro e sangue total foram coletadas para realização de reação de imunofluorescência indireta (RIFI) para T. gondii e E. canis e para avaliação hematológica. Observaram-se prevalências de 10,3 e 94,8% para T. gondii e E. canis respectivamente, e a síndrome mais frequente foi a multifocal ocorrendo em 53,5% dos casos, seguido de alterações medulares em 22,4%, alteração cerebral em 10,3%, síndrome paroxística em 10,3% dos casos e síndrome neuropática com 3,5% dos casos. Não houve associação estatística entre as variáveis analisadas (titulação para T. gondii, E. canis e síndromes nervosas). (AU)

Osteossarcoma em gato jovem - relato de caso / Osteosarcoma in a young cat - case report / Osteosarcoma en un gato joven - reporte de un caso

Tumores ósseos primários são raros em felinos, afetam principalmente animais idosos e apresentam predileção pelo esqueleto apendicular. Este trabalho relata o caso de um felino macho de dezoito meses de idade, mestiço, em adequado estado nutricional, que foi atendido com histórico de massa de crescimento rápido no membro pélvico direito. Apresentava-se ativo, porém com claudicação e dor no local. O exame físico e radiográfico levantou a suspeita de osteossarcoma apendicular, o que foi posteriormente confirmado por meio de histopatologia. O paciente foi submetido à amputação por meio de desarticulação coxofemoral. Devido ao baixo índice metastático nessa espécie não foram realizados protocolos quimioterápicos, e nos retornos periódicos o exame radiográfico não apresentou evidência de metástase. A baixa incidência nessa espécie felina, assim como a idade do paciente, justificam a relevância do presente relato.

Primary bone tumors are rare in cats; they affect mainly older animals and have a predilection for the appendicular skeleton. This paper reports the case of an eighteen-month-old male mongrel cat. The patient was active and in adequate nutritional status, but had a rapidly growing mass in the right pelvic limb, which caused lameness and pain at the site. Physical and radiographic examination suggested appendicular osteosarcoma, which was subsequently confirmed by histopathology. The patient underwent amputation by hip disarticulation. Due to the low metastatic rate in this species, chemotherapy protocols were not performed. Periodic post-surgical radiographic examinations showed no evidence of metastasis. Both the low incidence of this disease in this feline species and the patient's young age justify the relevance of this report.

Los tumores óseos primarios son poco frecuentes en los gatos y afectan principalmente a animales de edad avanzada, localizándose en la mayor parte de los casos en huesos largos. Este trabajo relata el caso de un gato macho de dieciocho meses de edad, mestizo y en adecuado estado nutricional, que se presentó a consulta con histórico de masa de crecimiento rápido en el miembro posterior derecho. El paciente se encontraba activo, aunque presentaba presencia de claudicación y dolor local. El examen físico y las radiografías llevaron a un diagnóstico presuntivo de osteosarcoma, posteriormente confirmado a través de la histopatología. El paciente fue amputado mediante desarticulación coxo femoral. Dado que el índice de metástasis es bajo en los gatos, no se indicó la realización de quimioterapia; y en los controles clínicos y radiográficos no se detectó la presencia de metástasis. La justificativa del presente relato se fundamenta en la baja incidencia de osteosarcomas en estos felinos, particularmente en animales de baja edad.

Osteossarcoma em gato jovem - relato de caso / Osteosarcoma in a young cat - case report / Osteosarcoma en un gato joven - reporte de un caso

Tumores ósseos primários são raros em felinos, afetam principalmente animais idosos e apresentam predileção pelo esqueleto apendicular. Este trabalho relata o caso de um felino macho de dezoito meses de idade, mestiço, em adequado estado nutricional, que foi atendido com histórico de massa de crescimento rápido no membro pélvico direito. Apresentava-se ativo, porém com claudicação e dor no local. O exame físico e radiográfico levantou a suspeita de osteossarcoma apendicular, o que foi posteriormente confirmado por meio de histopatologia. O paciente foi submetido à amputação por meio de desarticulação coxofemoral. Devido ao baixo índice metastático nessa espécie não foram realizados protocolos quimioterápicos, e nos retornos periódicos o exame radiográfico não apresentou evidência de metástase. A baixa incidência nessa espécie felina, assim como a idade do paciente, justificam a relevância do presente relato.(AU)

Primary bone tumors are rare in cats; they affect mainly older animals and have a predilection for the appendicular skeleton. This paper reports the case of an eighteen-month-old male mongrel cat. The patient was active and in adequate nutritional status, but had a rapidly growing mass in the right pelvic limb, which caused lameness and pain at the site. Physical and radiographic examination suggested appendicular osteosarcoma, which was subsequently confirmed by histopathology. The patient underwent amputation by hip disarticulation. Due to the low metastatic rate in this species, chemotherapy protocols were not performed. Periodic post-surgical radiographic examinations showed no evidence of metastasis. Both the low incidence of this disease in this feline species and the patient's young age justify the relevance of this report.(AU)

Los tumores óseos primarios son poco frecuentes en los gatos y afectan principalmente a animales de edad avanzada, localizándose en la mayor parte de los casos en huesos largos. Este trabajo relata el caso de un gato macho de dieciocho meses de edad, mestizo y en adecuado estado nutricional, que se presentó a consulta con histórico de masa de crecimiento rápido en el miembro posterior derecho. El paciente se encontraba activo, aunque presentaba presencia de claudicación y dolor local. El examen físico y las radiografías llevaron a un diagnóstico presuntivo de osteosarcoma, posteriormente confirmado a través de la histopatología. El paciente fue amputado mediante desarticulación coxo femoral. Dado que el índice de metástasis es bajo en los gatos, no se indicó la realización de quimioterapia; y en los controles clínicos y radiográficos no se detectó la presencia de metástasis. La justificativa del presente relato se fundamenta en la baja incidencia de osteosarcomas en estos felinos, particularmente en animales de baja edad.(AU)