Congenital renal hypoplasia and contralateral kidney failure in a giant otter (Pteronura brasiliensis) ex situ in Southeastern Brazil

Renal hypoplasia is incomplete development of the kidneys, in which fewer than normal numbers of nephrons are present at birth. This report is the first of these conditions in mustelids. A female adult giant otter (Pteronura brasiliensis), ex situ, presented clinically an unusual behavior with prostration, anorexia, hiding in the shelter, ataxia, paraparesis, and death in a clinical course of one day. At the postmortem exam, the left kidney was markedly enlarged and pale and the right kidney was severely reduced and had mild to moderate capsular thickening. Histologically, the left kidney had mineralization, proliferation of fibrous connective tissue and a mild neutrophilic infiltrate. The right kidney presented a reduced number of glomeruli, tubular atrophy and an increase in fibrous connective tissue, which were findings compatible with congenital kidney hypoplasia. Due the clinical condition of the animal, gross and microscopic findings, the cause of death was established as kidney failure induced by renal hypoplasia.(AU)

Mesotelioma peritoneal em onça-pintada (Panthera onca Linnaeus, 1758) / Peritoneal mesothelioma in jaguar (Panthera onca Linnaeus, 1758) / Mesotelioma peritoneal en jaguar (Panthera onca Linnaeus, 1758)

Mesoteliomas são neoplasias malignas que causam lesões graves e extensas em peritônio, pleura, pericárdio e órgãos adjacentes. O presente estudo de caso discorre sobre o óbito de uma onça-pintada (Panthera onca) mantida sob cuidados humanos em um zoológico do estado de São Paulo, com idade estimada de 19 anos, que apresentou aumento de volume abdominal, ascite, diminuição de deslocamento pelo recinto, inapetência e polidipsia. O paciente foi submetido a exames clínicos, laboratoriais e de diagnósticos por imagem, e em curto espaço de tempo foi a óbito. Os resultados anatomopatológicos e imuno-histoquímicos indicaram o diagnóstico conclusivo de mesotelioma peritoneal, com metástase em linfonodo mesenterico.(AU)

Mesotheliomas are malignant neoplasms and cause severe and extensive lesions in the peritoneum, pleura, pericardium and adjacent organs. The present case study discusses the death of a jaguar (Panthera onca) kept under human care in a zoo in the state of São Paulo, Brazil, with an estimated age of 19-years-old. He presented increased abdominal volume, ascites, decreased displacement by the enclosure, inappetence and polydipsia. The patient underwent clinical, laboratory and diagnostic imaging tests and died after a short period of time. The anatomopathological results indicated the diagnosis of peritoneal mesothelioma, with metastasis in the mesenteric lymph node.(AU)

Los mesoteliomas son neoplasias malignas y provocan lesiones graves y extensas en el peritoneo, pleura, pericardio y órganos adyacentes. El presente estudio de caso presenta la muerte de un jaguar (Panthera onca) mantenido bajo cuidado humano en un zoológico en el estado de São Paulo, Brasil, con una edad estimada de 19 años. El animal presentó aumento de volumen abdominal, ascitis, disminución del desplazamiento por el recinto, inapetencia y polidipsia. Al paciente se le realizaron pruebas clínicas, de laboratorio y de diagnóstico por imágenes, pero en poco tiempo falleció. Los resultados anatomopatológicos indicaron el diagnóstico de mesotelioma peritoneal, con metástasis en el ganglio mesenterico.(AU)

Unilateral renal agenesis in Chilean-flamingo (Phoenicopterus chilensis)

Background: Phoenicopterus chilensis is a South American wild bird classified as a near threatened specie in the List ofEndangered Species of the International Union for Conservation of Nature. With the increase of the contact between human population and wild animals, this species’ habitat is becoming increasingly vulnerable, with a declining population.Due to the importance of its conservation, the knowledge of abnormalities that affect this species becomes essential. Thisreport aims to describe the first diagnosed case of unilateral renal agenesis in chilean-flamingo.Case: A captive male chilean-flamingo (Phoenicopterus chilensis) was found dead in its enclosure and then was referredat necropsy. The cause of death was the presence of tracheal fungal granuloma, caused by Aspergillus sp. Macroscopically,during the examination of the body cavity, the absence of the right kidney was noted, also evidencing the absence of thecaudal renal vein. Emerging from the caudal division of the kidney was noted a blind-end renal vessel. For the histopathological examination, the remaining kidney was fixed in 10% formalin, processed by paraffin embedding technique andstained with Hematoxylin and Eosin (HE). When analyzing the left kidney parenchyma, preserved histological architecturewas noted, without any changes in the tissue structures of the organ. Thus, no hypertrophy by compensatory mechanismsof the remaining kidney was observed.Discussion: Unilateral renal agenesis is a very rare congenital defect in dogs, cats and also in birds. It occurs in the complete absence of one of the kidneys, a situation with which the animal can live satisfactorily if there is a normal kidney toassume the functions. In association, ipsilateral ureteral agenesis and compensatory...

Unilateral renal agenesis in Chilean-flamingo (Phoenicopterus chilensis)

Background: Phoenicopterus chilensis is a South American wild bird classified as a near threatened specie in the List ofEndangered Species of the International Union for Conservation of Nature. With the increase of the contact between human population and wild animals, this species habitat is becoming increasingly vulnerable, with a declining population.Due to the importance of its conservation, the knowledge of abnormalities that affect this species becomes essential. Thisreport aims to describe the first diagnosed case of unilateral renal agenesis in chilean-flamingo.Case: A captive male chilean-flamingo (Phoenicopterus chilensis) was found dead in its enclosure and then was referredat necropsy. The cause of death was the presence of tracheal fungal granuloma, caused by Aspergillus sp. Macroscopically,during the examination of the body cavity, the absence of the right kidney was noted, also evidencing the absence of thecaudal renal vein. Emerging from the caudal division of the kidney was noted a blind-end renal vessel. For the histopathological examination, the remaining kidney was fixed in 10% formalin, processed by paraffin embedding technique andstained with Hematoxylin and Eosin (HE). When analyzing the left kidney parenchyma, preserved histological architecturewas noted, without any changes in the tissue structures of the organ. Thus, no hypertrophy by compensatory mechanismsof the remaining kidney was observed.Discussion: Unilateral renal agenesis is a very rare congenital defect in dogs, cats and also in birds. It occurs in the complete absence of one of the kidneys, a situation with which the animal can live satisfactorily if there is a normal kidney toassume the functions. In association, ipsilateral ureteral agenesis and compensatory...(AU)

Neoplasia testicular em jaguatirica (Leopardus pardalis – Linnaeus, 1758) / Testicular neoplasm in ocelot (Leopardus pardalis – Linnaeus, 1758) / Neoplasia testicular en ocelote (Leopardus pardalis – Linnaeus, 1758)

O crescimento neoplásico é definido como proliferação autônoma e progressiva das células, que na maioria dos casos está correlacionada à presença de massa ou tumor. As neoplasias são pouco relatadas em felinos silvestres e a indicação quase sempre é a exérese da neoformação. Há um significativo aumento na incidência de neoplasias em animais silvestres mantidos sob cuidados humanos, provavelmente relacionadas ao aumento da taxa de longevidade dos animais em zoológicos. Um exemplar de jaguatirica (Leopardus pardalis) apresentou aumento de volume do testículo direito e foi submetido a exames de imagens e laboratoriais. O exame citológico e histopatológico foi conclusivo para seminoma, e o paciente foi submetido a orquiectomia unilateral. O felino apresentou recuperação satisfatória e será acompanhado pelos próximos anos para o monitoramento da neoplasia no organismo. Esse é o primeiro relato de seminoma em jaguatirica.

Neoplastic growth is defined as an autonomous and progressive proliferation of cells which, in most cases, is correlated with the presence of a mass or tumor. Neoplasms are rarely reported in wild cats and the indicated treatment is almost always the excision of the new formation. There is a significant increase in the incidence of neoplasms in wild animals under human care, probably related to the increase in the longevity rate of animals kept in zoos. A specimen of ocelot (Leopardus pardalis) showed an increase in the volume of the right testicle and the patient was submitted to imaging and laboratory tests. The diagnosis was conclusive for seminoma and the patient underwent a unilateral orchiectomy. The patient has recovered well and will be followed-up over the next few years to monitor the presence of neoplasm in the body. This is the first report of seminoma in an ocelot.

El crecimiento de una neoplasia se caracteriza por la proliferación autónoma y progresiva de las células, que en la mayoría de los casos está relacionada con la presencia de una masa o un tumor. Existen pocos relatos de tumores en felinos salvajes, en los que está indicada casi siempre su extirpación. Se ha comprobado un aumento significativo de las neoplasias en animales salvajes bajo cuidados humanos, probablemente relacionado con la mayor longevidad de esos animales en zoológicos. Un ocelote (Leopardus pardalis) presentó aumento de volumen del testículo derecho. Fueran realizados exámenes de laboratorio y de imágenes. Los exámenes tológicos e histopatológicos evidenciaron la presencia de un seminoma, por lo que fue realizada una orquiectomía unilateral. El felino tuvo una recuperación satisfactoria y será controlado durante los próximos años ante la eventual aparición de otros tumores, recidiva o metástasis. Este es el primer relato de un seminoma en un ocelote.

Mycobacterium genavense infection in two species of captive snakes

Background: Mycobacterium is an important zoonotic agent with companion, livestock and wildlife animals reportedly playing a role as reservoirs. Although its association with reptiles has been described, the disease cycle remains to be fully established, particularly in snakes. Accordingly, this study aimed to report the occurrence of mycobacteriosis with clinical pneumonia in one exotic python snake (Python molurus) and one native green snake (Philodryas olfersii) from the Sorocaba Zoo, São Paulo state, Brazil. Methods: Diagnosis was based on necropsy, histopathological examination, Ziehl-Neelsen stain and immunohistochemistry. Results: Using a nested PCR followed by DNA sequencing and bioinformatics analysis, the causative Mycobacterium species was identified as Mycobacterium genavense. Conclusion: Mycobacterium genavense is an infectious zoonotic agent of animal and public health concerns.(AU)

Mycobacterium genavense infection in two species of captive snakes

Mycobacterium is an important zoonotic agent with companion, livestock and wildlife animals reportedly playing a role as reservoirs. Although its association with reptiles has been described, the disease cycle remains to be fully established, particularly in snakes. Accordingly, this study aimed to report the occurrence of mycobacteriosis with clinical pneumonia in one exotic python snake (Python molurus) and one native green snake (Philodryas olfersii) from the Sorocaba Zoo, São Paulo state, Brazil. Methods: Diagnosis was based on necropsy, histopathological examination, Ziehl-Neelsen stain and immunohistochemistry. Results: Using a nested PCR followed by DNA sequencing and bioinformatics analysis, the causative Mycobacterium species was identified as Mycobacterium genavense. Conclusion: Mycobacterium genavense is an infectious zoonotic agent of animal and public health concerns.(AU)

Neoplasia testicular em jaguatirica (Leopardus pardalis Linnaeus, 1758) / Testicular neoplasm in ocelot (Leopardus pardalis Linnaeus, 1758) / Neoplasia testicular en ocelote (Leopardus pardalis Linnaeus, 1758)

O crescimento neoplásico é definido como proliferação autônoma e progressiva das células, que na maioria dos casos está correlacionada à presença de massa ou tumor. As neoplasias são pouco relatadas em felinos silvestres e a indicação quase sempre é a exérese da neoformação. Há um significativo aumento na incidência de neoplasias em animais silvestres mantidos sob cuidados humanos, provavelmente relacionadas ao aumento da taxa de longevidade dos animais em zoológicos. Um exemplar de jaguatirica (Leopardus pardalis) apresentou aumento de volume do testículo direito e foi submetido a exames de imagens e laboratoriais. O exame citológico e histopatológico foi conclusivo para seminoma, e o paciente foi submetido a orquiectomia unilateral. O felino apresentou recuperação satisfatória e será acompanhado pelos próximos anos para o monitoramento da neoplasia no organismo. Esse é o primeiro relato de seminoma em jaguatirica.(AU)

Neoplastic growth is defined as an autonomous and progressive proliferation of cells which, in most cases, is correlated with the presence of a mass or tumor. Neoplasms are rarely reported in wild cats and the indicated treatment is almost always the excision of the new formation. There is a significant increase in the incidence of neoplasms in wild animals under human care, probably related to the increase in the longevity rate of animals kept in zoos. A specimen of ocelot (Leopardus pardalis) showed an increase in the volume of the right testicle and the patient was submitted to imaging and laboratory tests. The diagnosis was conclusive for seminoma and the patient underwent a unilateral orchiectomy. The patient has recovered well and will be followed-up over the next few years to monitor the presence of neoplasm in the body. This is the first report of seminoma in an ocelot.(AU)

El crecimiento de una neoplasia se caracteriza por la proliferación autónoma y progresiva de las células, que en la mayoría de los casos está relacionada con la presencia de una masa o un tumor. Existen pocos relatos de tumores en felinos salvajes, en los que está indicada casi siempre su extirpación. Se ha comprobado un aumento significativo de las neoplasias en animales salvajes bajo cuidados humanos, probablemente relacionado con la mayor longevidad de esos animales en zoológicos. Un ocelote (Leopardus pardalis) presentó aumento de volumen del testículo derecho. Fueran realizados exámenes de laboratorio y de imágenes. Los exámenes tológicos e histopatológicos evidenciaron la presencia de un seminoma, por lo que fue realizada una orquiectomía unilateral. El felino tuvo una recuperación satisfactoria y será controlado durante los próximos años ante la eventual aparición de otros tumores, recidiva o metástasis. Este es el primer relato de un seminoma en un ocelote.(AU)

Mycobacterium genavense infection in two species of captive snakes

Mycobacterium is an important zoonotic agent with companion, livestock and wildlife animals reportedly playing a role as reservoirs. Although its association with reptiles has been described, the disease cycle remains to be fully established, particularly in snakes. Accordingly, this study aimed to report the occurrence of mycobacteriosis with clinical pneumonia in one exotic python snake (Python molurus) and one native green snake (Philodryas olfersii) from the Sorocaba Zoo, São Paulo state, Brazil. Methods: Diagnosis was based on necropsy, histopathological examination, Ziehl-Neelsen stain and immunohistochemistry. Results: Using a nested PCR followed by DNA sequencing and bioinformatics analysis, the causative Mycobacterium species was identified as Mycobacterium genavense. Conclusion: Mycobacterium genavense is an infectious zoonotic agent of animal and public health concerns.

Linfoma renal felino (relato de caso) / Feline renal lymphoma - case report / Linfoma renal felino - informe de un caso

O linfoma renal é uma neoplasia comum em felinos. Sua etiologia muitas vezes é associada à infecção por retrovírus da leucemia felina e da imunodeficiência felina, podendo também ocorrer de forma isolada. Os sintomas decorrentes são característicos de doença renal crônica como anorexia, apatia, emese, poliúria, polidipsia e emagrecimento progressivo. O diagnóstico definitivo da neoplasia é realizado através de exame histopatológico e o tratamento de eleição é a quimioterapia. O prognóstico é desfavorável devido à presença de síndrome paraneoplásica, ao desenvolvimento de metástases, à insuficiência renal crônica instalada e pela possibilidade de também haver doença viral concorrente. Este relato de caso tem o objetivo de atentar o clinico veterinário para a importância da sorologia precoce para FeLV e FIVna ocorrência de neoplasia renal.(AU)

Renal lymphoma is a common cancer incats. Its etiology is often associated with retrovirus infection of feline leukemia and feline immunodeficiency virus, but may also occur in isolation. Symptoms are characteristic of chronic kidney disease as anorexia, lethargy, emesis, polyuria, polydipsia, and progressive weight loss. The definitive diagnosis of cancer is made through histopathology and treatment of choice is chemotherapy. Presence of paraneoplastic syndrome, development of metastasis, chronic renal failure installed and possibility of also having concurrent viral disease may complicate the unfavorable prognosis. This case report aims to attend the veterinary clinician to the importance of early FeLV and FIV serology for the development of kidney cancer.(AU)

El linfoma renal es un cáncer común en gatos. Su etiología es a menu do asociada con la infección por retrovirus de la leucemia felina y de la inmunodeficiencia felina, también puede ocurrir en el aislamiento. Los síntomas son característicos de la enfermedad renal crónica y resultan en anorexia, letargo, vómitos, poliuria, polidipsia y la pérdida progresiva de peso. El diagnóstico definitivo de la neoplasia se lleva a cabo a través de histopatología y el tratamiento de elección es la quimioterapia. El pronóstico es desfavorable debido a la presencia del síndrome paraneoplásico, el desarrollo de metástasis, insuficiencia renal crónica instalada y también por la posibilidad de una enfermedad viral que compiten. Este informe de caso tiene como objetivo asistir 10 clínico veterinario de la importancia de serologías precoces de FeLV y FIV en el desarrollo de neoplasias renales.(AU)

Linfoma renal felino (relato de caso) / Feline renal lymphoma - case report / Linfoma renal felino - informe de un caso

O linfoma renal é uma neoplasia comum em felinos. Sua etiologia muitas vezes é associada à infecção por retrovírus da leucemia felina e da imunodeficiência felina, podendo também ocorrer de forma isolada. Os sintomas decorrentes são característicos de doença renal crônica como anorexia, apatia, emese, poliúria, polidipsia e emagrecimento progressivo. O diagnóstico definitivo da neoplasia é realizado através de exame histopatológico e o tratamento de eleição é a quimioterapia. O prognóstico é desfavorável devido à presença de síndrome paraneoplásica, ao desenvolvimento de metástases, à insuficiência renal crônica instalada e pela possibilidade de também haver doença viral concorrente. Este relato de caso tem o objetivo de atentar o clinico veterinário para a importância da sorologia precoce para FeLV e FIVna ocorrência de neoplasia renal.

Renal lymphoma is a common cancer incats. Its etiology is often associated with retrovirus infection of feline leukemia and feline immunodeficiency virus, but may also occur in isolation. Symptoms are characteristic of chronic kidney disease as anorexia, lethargy, emesis, polyuria, polydipsia, and progressive weight loss. The definitive diagnosis of cancer is made through histopathology and treatment of choice is chemotherapy. Presence of paraneoplastic syndrome, development of metastasis, chronic renal failure installed and possibility of also having concurrent viral disease may complicate the unfavorable prognosis. This case report aims to attend the veterinary clinician to the importance of early FeLV and FIV serology for the development of kidney cancer.

El linfoma renal es un cáncer común en gatos. Su etiología es a menu do asociada con la infección por retrovirus de la leucemia felina y de la inmunodeficiencia felina, también puede ocurrir en el aislamiento. Los síntomas son característicos de la enfermedad renal crónica y resultan en anorexia, letargo, vómitos, poliuria, polidipsia y la pérdida progresiva de peso. El diagnóstico definitivo de la neoplasia se lleva a cabo a través de histopatología y el tratamiento de elección es la quimioterapia. El pronóstico es desfavorable debido a la presencia del síndrome paraneoplásico, el desarrollo de metástasis, insuficiencia renal crónica instalada y también por la posibilidad de una enfermedad viral que compiten. Este informe de caso tiene como objetivo asistir 10 clínico veterinario de la importancia de serologías precoces de FeLV y FIV en el desarrollo de neoplasias renales.

Linfoma multicêntrico em um quati (Carnivora: Procyonidae, NasuaNasua) / Multicentric lymphoma in coati (Carnivora: Procyonidae, Nasua Nasua)

Relata-se o caso de um quati, recebido pela Divisão Fauna Silvestre da Prefeitura de São Paulo e mantido emcativeiro pela impossibilidade de reintrodução do mesmo ao seu habitat natural. Possuindo cerca de três anosde idade, apresentou anorexia, espirros e andar cambaleante, respondendo ao tratamento clínico. Passadosquatro meses, apresentou perda de peso, prostração, mucosas hipocoradas, apatia e diarréia persistente. Noexame físico, havia marcante aumento de volume abdominal. Os exames hematológicos, bioquímicos e aurinálise apresentavam-se alterados. O exame ultrassonográfico abdominal sugeriu um processo neoplásico.A partir dessa suspeita e do intenso sofrimento apresentado pelo animal, optou-se pela eutanásia. O examenecroscópico revelou a presença de formações de consistência macia e coloração esbranquiçada em rins, pulmão,mucosa gástrica e cavidade abdominal. Havia linfonodomegalia e discreta enterite. O exame histopatológicodemonstrou infiltração de células neoplásicas em diversos órgãos e proliferação neoplásica linfocitáriaem linfonodos e em formação abdominal. O quadro microscópico foi compatível com Linfoma de baixo grau,com metástase. Devido à distribuição das lesões, foi classificado como linfoma multicêntrico. O estudo imunohistoquímiconão permitiu definir a histogênese das células neoplásicas, porém os aspectos morfológicosfavoreceram o diagnóstico de linfoma. Este é o primeiro relato de caso de linfoma multicêntrico em quati.(AU)

This is a report of case of a coati received by the Wildlife Division of São Paulo City Hall. It was held incaptivity by the impossibility of reintroduction to its natural habitat. When it was nearly three years old, it had anorexia, sneezing and incoordination, responding to medical treatment. After four months, itshowed weight loss, prostration, pale mucous membranes, lethargy, and persistent diarrhea. On physicalexamination, there was marked abdominal distension. The hematological, biochemical and urinalysiswere abnormal. The abdominal ultrasound suggested a neoplastic process. From that suspicion and intensesuffering brought by the animal, it was decided to euthanasia. The necropsy revealed the presenceof formations with a soft consistency and whitish coloration in kidney, lung, gastric mucosa and abdominalcavity. There was lymphadenopathy and mild enteritis. Histopathological examination showedinfiltration of neoplastic cells in various organs and neoplastic lymphocyte proliferation in lymph nodesand abdominal mass. The microscopic picture was compatible with low-grade lymphoma, metastatic.Due to the distribution of lesions, it was classified as multicentric lymphoma. An immunohistochemicalstudy did not allow defining the histogenesis of the neoplastic cells, but morphological features favoredthe diagnosis of lymphoma. This is the first case report of multicentric lymphoma in coati.(AU)

Linfoma multicêntrico em um quati (Carnivora: Procyonidae, NasuaNasua) / Multicentric lymphoma in coati (Carnivora: Procyonidae, Nasua Nasua)

Relata-se o caso de um quati, recebido pela Divisão Fauna Silvestre da Prefeitura de São Paulo e mantido emcativeiro pela impossibilidade de reintrodução do mesmo ao seu habitat natural. Possuindo cerca de três anosde idade, apresentou anorexia, espirros e andar cambaleante, respondendo ao tratamento clínico. Passadosquatro meses, apresentou perda de peso, prostração, mucosas hipocoradas, apatia e diarréia persistente. Noexame físico, havia marcante aumento de volume abdominal. Os exames hematológicos, bioquímicos e aurinálise apresentavam-se alterados. O exame ultrassonográfico abdominal sugeriu um processo neoplásico.A partir dessa suspeita e do intenso sofrimento apresentado pelo animal, optou-se pela eutanásia. O examenecroscópico revelou a presença de formações de consistência macia e coloração esbranquiçada em rins, pulmão,mucosa gástrica e cavidade abdominal. Havia linfonodomegalia e discreta enterite. O exame histopatológicodemonstrou infiltração de células neoplásicas em diversos órgãos e proliferação neoplásica linfocitáriaem linfonodos e em formação abdominal. O quadro microscópico foi compatível com Linfoma de baixo grau,com metástase. Devido à distribuição das lesões, foi classificado como linfoma multicêntrico. O estudo imunohistoquímiconão permitiu definir a histogênese das células neoplásicas, porém os aspectos morfológicosfavoreceram o diagnóstico de linfoma. Este é o primeiro relato de caso de linfoma multicêntrico em quati.

This is a report of case of a coati received by the Wildlife Division of São Paulo City Hall. It was held incaptivity by the impossibility of reintroduction to its natural habitat. When it was nearly three years old, it had anorexia, sneezing and incoordination, responding to medical treatment. After four months, itshowed weight loss, prostration, pale mucous membranes, lethargy, and persistent diarrhea. On physicalexamination, there was marked abdominal distension. The hematological, biochemical and urinalysiswere abnormal. The abdominal ultrasound suggested a neoplastic process. From that suspicion and intensesuffering brought by the animal, it was decided to euthanasia. The necropsy revealed the presenceof formations with a soft consistency and whitish coloration in kidney, lung, gastric mucosa and abdominalcavity. There was lymphadenopathy and mild enteritis. Histopathological examination showedinfiltration of neoplastic cells in various organs and neoplastic lymphocyte proliferation in lymph nodesand abdominal mass. The microscopic picture was compatible with low-grade lymphoma, metastatic.Due to the distribution of lesions, it was classified as multicentric lymphoma. An immunohistochemicalstudy did not allow defining the histogenesis of the neoplastic cells, but morphological features favoredthe diagnosis of lymphoma. This is the first case report of multicentric lymphoma in coati.