Efeito do extrato etanólico das folhas de Myracrodruon urundeuva sobre a contratilidade uterina de ratas Wistar / Effect of ethanol extract of Myracrodruon urundeuva leaves on contractility uterine of Wistar rats

Were used 30 virgin female Wistar rats that were mated with adult male rats and vaginal smears were made to detect pregnancy. The pregnant rats were subdivided into pre-treated group with ethanol extract of M. urundeuva (EEMU) at doses of 125, 250 and 500mg/kg PO for 13 days and the untreated group that receiving distilled water being the extract at concentrations of 125, 250 and 500µg/mL added directly to the bath tub for isolated organ. Rats were euthanized by anesthetic overdose and the uterine strips were placed in the bath tub for isolated organ and subjected to contraction with 80mM KCl, oxytocin (16.8IU/mg) and Carbachol (0.3µM). Treatment with EEMU and its direct application did not interfere with uterine contractility of pregnant rats.

Efeito do extrato etanólico das folhas de Myracrodruon urundeuva sobre a contratilidade uterina de ratas Wistar / Effect of ethanol extract of Myracrodruon urundeuva leaves on contractility uterine of Wistar rats

Were used 30 virgin female Wistar rats that were mated with adult male rats and vaginal smears were made to detect pregnancy. The pregnant rats were subdivided into pre-treated group with ethanol extract of M. urundeuva (EEMU) at doses of 125, 250 and 500mg/kg PO for 13 days and the untreated group that receiving distilled water being the extract at concentrations of 125, 250 and 500µg/mL added directly to the bath tub for isolated organ. Rats were euthanized by anesthetic overdose and the uterine strips were placed in the bath tub for isolated organ and subjected to contraction with 80mM KCl, oxytocin (16.8IU/mg) and Carbachol (0.3µM). Treatment with EEMU and its direct application did not interfere with uterine contractility of pregnant rats.(AU)

Efeito pró-erétil em ratos tratados com extrato etanólico das vagens de Senna spectabilis / Pro-erectile effect in rats treated with ethanol extract of pods of Senna spectabilis

This study aimed analize the Pro-erectile effect of rats trated with ethanol extract os pods of Sennaspectabilis (EEVSs), a native plant from Savana, predominant on brazilian northwest. Compreendendo que Thefeed is an important aspect for the development of good breeders and reproductive risk of failures caused byempirical use of native plants in the feeding of cattle can not be ignoredWere used 40 Wistar rats separated inthree groups treated with EEVSs and one group treated with apomorphine and another treated with distilledwater. After each treatment the animals were observed In a transparent chamber. The rats that received theEEVSs showed no significant alterations. However at presence of apomorphine there was an increase of penileerection, for it is an dopaminergic agonist.(AU)

Frequência de ejaculação de ratos tratados com extrato etanólico de Senna spectabilis / Ejaculation frequency of rats treated with ethanol extract of Senna spectabilis

This study aimed analyse the effects of Senna spectabilis on ejaculatory frequency and copulatoryparameters of rats, getting some answers related to aphrodisiacs and adverse effects and potential influencers inthe sexual behavior of animals observed in some species of plants similar to Senna spectabilis. Were used 35Wistar ratos, being 28 with erectile dysfunction induced by paroxetine The ethanol extract of S. spectabilis(EESs) were administered in three different doses (250, 500 and 1000 mg/kg body weight) for seven consecutivedays. Then the rats were allocated in cages with female rats at estrus phase and the ejaculatory frequency wasnoted. The animals in this study showed no erection while they were on observation and no significantbehavioral change was observed, compared to the control group.(AU)

Efeito do óleo essencial dos frutos de aroeira vermelha (Schinus terebinthifolius Raddi) no período pré-implante de ratas prenhes / Effect of oil essential of aroeira vermelha (Schinus terebinthifolius Raddi) in period of pre-implantation of pregnant rats

Medicinal plants are important for supplying raw materials for the synthesis of drugs and may also betoxic. The species Schinus terebinthifolius Raddi, popularly known as aroeira red or pink pepper is widelyconsumed by many people. This study aimed to assess adverse effects of the essential oil from the fruits ofSchinus terebinthifolius on pregnancy, administered during the preimplantation period. We used 32 pregnantanimals divided into four groups, a control (Tween 80) and three treated oil at doses of 25mg / kg, 50mg / kgand 100mg / kg treated once daily, the first to the seventh day of pregnancy, orally. Statistically there was nodifference between the treated groups compared to pre-implant loss, but there was a statistically significantdifference with respect to the increased weight of the empty uterus, both in relative mass as absolute. It isconcluded that the rats treated with oil of mastic-red fruits showed signs of gestational toxicity.(AU)

Efeito do óleo essencial dos frutos de aroeira-vermelha (Schinus terebinthifolius Raddi) no desenvolvimento da progênie de ratas / Effect of oil essential of aroeira red (Schinus terebinthifolius Raddi) in the development of rat progeny

The aroeira red is a plant of the species Schinus terebinthifolius Raddi, a plant native to Brazil andused in folk medicine for several people. This work was the objective of evaluate in the development of theprogeny of rats treated with essential oil of fruits of aroeira red. Was used four groups of pregnant rats, wherethree groups were treated with the oil at doses of 25, 50 and 100mg /kg each, and one control group treated withTween 80. All groups were treated orally once a day, from the 8º day of pregnancy until day before the birth,who interrupted in parturition day and continued treatment until day weaning (± 21 days). It was observed thatthere was an increase in bilateral ankle sprain while the progenies in the two higher doses. We conclude thatfemale rats treated with OE-St in the post-implementation period, showed a possible maternal-fetal toxicit.(AU)

Avaliação do ciclo estral e da toxicidade sistêmica do látex de Himatanthus sucuuba (Spruce) Woodson em ratas Wistar / The estrous cycle evaluation and systemic toxicity in the latex of Himatanthus sucuuba (Spruce) Woodson in Wistar rats

It aimed to investigate the possible effects induced by the diluted latex oral administration of H. sucuuba(LdHs) in Wistar rats on the estrous cycle and other organ systems. The Wistar rats received by gavage the LdHs.The results showed that there was a decrease in average daily intake and ponderable development negativeinterference in the group treated with the dose 100 mg / kg. The number of primary follicles and in the dose 100 mg/ kg LdHs was superior to the control group. It was also observed a decrease in the number of estrous cycles andan increase in the average duration of the estrous cycle in this group. Therefore, doses 25 and 50 mg / kg of LdHshave been shown safe, however the dose 100 mg / kg decreased reproductive efficiency and promoted a lowsystemic toxicity as caused a decrease in feed consumption and interfered with the ponderable development.(AU)

Pesquisa de atividade androgênica e antiandrogênica em ratos tratados com extrato etanólico das vagens de Senna spectabilis / Evaluation of Androgenic and antiandrogenic activity in rats treated with ethanol extract of pods of Senna spectabilis

Although the high expression of the northeastern herds, the levels of productivity, reproducibility,carcass gain and other factors are low. This is mainly due to the main food source being from native plants ofthe Savanna. Were used male Wistar rats (64) divided into eight groups. These animals were castrated and, afterrecovery, received ethanol extract of pods of Senna spectabilis (EEVSs) in three different doses and testosteroneintramuscularly (some groups). The animals were treated for 32 consecutive days and at the end wereeuthanized. The organs were collected and weighed for evaluation of androgenic and anti-androgenic activity.The extract showed no androgenic nor anti-androgenic activity at the doses tested.(AU)

Avaliação do ciclo estral e da toxicidade sistêmica do látex de Himatanthus sucuuba (Spruce) Woodson em ratas Wistar / The estrous cycle evaluation and systemic toxicity in the latex of Himatanthus sucuuba (Spruce) Woodson in Wistar rats

It aimed to investigate the possible effects induced by the diluted latex oral administration of H. sucuuba(LdHs) in Wistar rats on the estrous cycle and other organ systems. The Wistar rats received by gavage the LdHs.The results showed that there was a decrease in average daily intake and ponderable development negativeinterference in the group treated with the dose 100 mg / kg. The number of primary follicles and in the dose 100 mg/ kg LdHs was superior to the control group. It was also observed a decrease in the number of estrous cycles andan increase in the average duration of the estrous cycle in this group. Therefore, doses 25 and 50 mg / kg of LdHshave been shown safe, however the dose 100 mg / kg decreased reproductive efficiency and promoted a lowsystemic toxicity as caused a decrease in feed consumption and interfered with the ponderable development.

Efeito do óleo essencial dos frutos de aroeira vermelha (Schinus terebinthifolius Raddi) no período pré-implante de ratas prenhes / Effect of oil essential of aroeira vermelha (Schinus terebinthifolius Raddi) in period of pre-implantation of pregnant rats

Medicinal plants are important for supplying raw materials for the synthesis of drugs and may also betoxic. The species Schinus terebinthifolius Raddi, popularly known as aroeira red or pink pepper is widelyconsumed by many people. This study aimed to assess adverse effects of the essential oil from the fruits ofSchinus terebinthifolius on pregnancy, administered during the preimplantation period. We used 32 pregnantanimals divided into four groups, a control (Tween 80) and three treated oil at doses of 25mg / kg, 50mg / kgand 100mg / kg treated once daily, the first to the seventh day of pregnancy, orally. Statistically there was nodifference between the treated groups compared to pre-implant loss, but there was a statistically significantdifference with respect to the increased weight of the empty uterus, both in relative mass as absolute. It isconcluded that the rats treated with oil of mastic-red fruits showed signs of gestational toxicity.

Efeito do óleo essencial dos frutos de aroeira-vermelha (Schinus terebinthifolius Raddi) no desenvolvimento da progênie de ratas / Effect of oil essential of aroeira red (Schinus terebinthifolius Raddi) in the development of rat progeny

The aroeira red is a plant of the species Schinus terebinthifolius Raddi, a plant native to Brazil andused in folk medicine for several people. This work was the objective of evaluate in the development of theprogeny of rats treated with essential oil of fruits of aroeira red. Was used four groups of pregnant rats, wherethree groups were treated with the oil at doses of 25, 50 and 100mg /kg each, and one control group treated withTween 80. All groups were treated orally once a day, from the 8º day of pregnancy until day before the birth,who interrupted in parturition day and continued treatment until day weaning (± 21 days). It was observed thatthere was an increase in bilateral ankle sprain while the progenies in the two higher doses. We conclude thatfemale rats treated with OE-St in the post-implementation period, showed a possible maternal-fetal toxicit.

Frequência de ejaculação de ratos tratados com extrato etanólico de Senna spectabilis / Ejaculation frequency of rats treated with ethanol extract of Senna spectabilis

This study aimed analyse the effects of Senna spectabilis on ejaculatory frequency and copulatoryparameters of rats, getting some answers related to aphrodisiacs and adverse effects and potential influencers inthe sexual behavior of animals observed in some species of plants similar to Senna spectabilis. Were used 35Wistar ratos, being 28 with erectile dysfunction induced by paroxetine The ethanol extract of S. spectabilis(EESs) were administered in three different doses (250, 500 and 1000 mg/kg body weight) for seven consecutivedays. Then the rats were allocated in cages with female rats at estrus phase and the ejaculatory frequency wasnoted. The animals in this study showed no erection while they were on observation and no significantbehavioral change was observed, compared to the control group.

Pesquisa de atividade androgênica e antiandrogênica em ratos tratados com extrato etanólico das vagens de Senna spectabilis / Evaluation of Androgenic and antiandrogenic activity in rats treated with ethanol extract of pods of Senna spectabilis

Although the high expression of the northeastern herds, the levels of productivity, reproducibility,carcass gain and other factors are low. This is mainly due to the main food source being from native plants ofthe Savanna. Were used male Wistar rats (64) divided into eight groups. These animals were castrated and, afterrecovery, received ethanol extract of pods of Senna spectabilis (EEVSs) in three different doses and testosteroneintramuscularly (some groups). The animals were treated for 32 consecutive days and at the end wereeuthanized. The organs were collected and weighed for evaluation of androgenic and anti-androgenic activity.The extract showed no androgenic nor anti-androgenic activity at the doses tested.

Efeito pró-erétil em ratos tratados com extrato etanólico das vagens de Senna spectabilis / Pro-erectile effect in rats treated with ethanol extract of pods of Senna spectabilis

This study aimed analize the Pro-erectile effect of rats trated with ethanol extract os pods of Sennaspectabilis (EEVSs), a native plant from Savana, predominant on brazilian northwest. Compreendendo que Thefeed is an important aspect for the development of good breeders and reproductive risk of failures caused byempirical use of native plants in the feeding of cattle can not be ignoredWere used 40 Wistar rats separated inthree groups treated with EEVSs and one group treated with apomorphine and another treated with distilledwater. After each treatment the animals were observed In a transparent chamber. The rats that received theEEVSs showed no significant alterations. However at presence of apomorphine there was an increase of penileerection, for it is an dopaminergic agonist.