Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep / Efeitos cardiorrespiratórios e hemogasométricos da cetamina e suas associações com morfina e xilazina por via epidural em ovinos

This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best opti

Este estudo teve como objetivo avaliar os efeitos cardiorrespiratórios e hemogasométricos da cetamina peridural e suas associações com morfina e xilazina em ovelhas submetidas à manipulação uterina por via transcervical. Foram estudadas dez ovelhas da raça Santa Inês. Três protocolos epidurais foram avaliados: (GK = cetamina 2,0 mg kg−1, GKM = cetamina 2,0 mg kg−1 + morfina 0,1 mg kg−1, GKX = cetamina 2,0 mg kg−1 + xilazina 0,05 mg kg−1). Os três protocolos foram comparados entre si e com um tratamento controle (GS = solução salina 1 mL/7,5kg). As variáveis avaliadas foram frequência cardíaca, frequência respiratória, temperatura auricular, pressão arterial não-invasiva além da análise hemogasométrica. Todos os parâmetros foram avaliados no momento basal e em seguida as ovelhas foram sedadas com associação de acepromazina (0,1 mg kg−1) e diazepam (0,2 mg kg−1). Dez minutos após a sedação, todos os parâmetros foram novamente avaliados e foram realizadas as injeções peridurais. A hemogasometria foi repetida aos 15 e 30 minutos após a peridural e os outros parâmetros avaliados aos 05, 15, 30, 45, e 60 minutos após a peridural. O GKX mostrou sinais de hipoxemia com menores níveis de pO2 e um aumento compensatório na frequência respiratória. O GKM apresentou a média de temperatura mais baixa. Todos os protocolos apresentaram poucos efeitos cardiorrespiratórios em relação ao controle. O protocolo epidural com 2,0 mg kg−1 de cetamina foi considerado a melhor opção para procedimentos curtos como manipulações obstétricas em ovinos devido à estabilidade cardiorrespiratória quando comparado com os protocolos que utilizaram associações.(AU)

Cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in sheep / Efeitos cardiorrespiratórios e hemogasométricos da cetamina e suas associações com morfina e xilazina por via epidural em ovinos

This study aimed to evaluate the cardiorespiratory and hemogasometric effects of epidural ketamine and its associations with morphine and xylazine in ewes submitted to transcervical cervix transposition with a hegar dilator. Ten Santa Inês breed ewes were studied in a cross over model study where three epidural protocols (GK = ketamine 2.0 mg kg-1; GKM = ketamine 2.0 mg kg-1 + morphine 0.1 mg kg-1; GKX = ketamine 2.0 mg kg-1 + xylazine 0.05 mg kg-1) were compared among each other and with a control treatment (GS= saline 1 mL/7.5 kg). The assessed variables were heart rate, respiratory frequency, ear temperature, non-invasive blood pressure and hemogasometric analysis. All parameters were assessed at baseline and then ewes were sedated with an association of acepromazine (0.1 mg kg -1) and diazepam (0.2 mg kg -1). Ten minutes after sedation all parameters were reassessed and afterwards the epidural injections were performed. Hemogasometry was repeated at 15 and 30 minutes after epidural and the other parameters assessed at 05, 15, 30, 45 and 60 minutes after epidural. GKX showed a slight respiratory depression with lower levels of PO2 and a compensatory increase in respiratory frequency. GKM presented the lower temperature mean. All protocols showed few cardiorespiratory effects when compared with control. Epidural with 2.0 mg kg-1 ketamine isolated was considered the best opti

Este estudo teve como objetivo avaliar os efeitos cardiorrespiratórios e hemogasométricos da cetamina peridural e suas associações com morfina e xilazina em ovelhas submetidas à manipulação uterina por via transcervical. Foram estudadas dez ovelhas da raça Santa Inês. Três protocolos epidurais foram avaliados: (GK = cetamina 2,0 mg kg−1, GKM = cetamina 2,0 mg kg−1 + morfina 0,1 mg kg−1, GKX = cetamina 2,0 mg kg−1 + xilazina 0,05 mg kg−1). Os três protocolos foram comparados entre si e com um tratamento controle (GS = solução salina 1 mL/7,5kg). As variáveis avaliadas foram frequência cardíaca, frequência respiratória, temperatura auricular, pressão arterial não-invasiva além da análise hemogasométrica. Todos os parâmetros foram avaliados no momento basal e em seguida as ovelhas foram sedadas com associação de acepromazina (0,1 mg kg−1) e diazepam (0,2 mg kg−1). Dez minutos após a sedação, todos os parâmetros foram novamente avaliados e foram realizadas as injeções peridurais. A hemogasometria foi repetida aos 15 e 30 minutos após a peridural e os outros parâmetros avaliados aos 05, 15, 30, 45, e 60 minutos após a peridural. O GKX mostrou sinais de hipoxemia com menores níveis de pO2 e um aumento compensatório na frequência respiratória. O GKM apresentou a média de temperatura mais baixa. Todos os protocolos apresentaram poucos efeitos cardiorrespiratórios em relação ao controle. O protocolo epidural com 2,0 mg kg−1 de cetamina foi considerado a melhor opção para procedimentos curtos como manipulações obstétricas em ovinos devido à estabilidade cardiorrespiratória quando comparado com os protocolos que utilizaram associações.

Bloqueio de plexo braquial guiado por neuroestimulador para amputação em bezerro / Nerve stimulator-guided brachial plexus block performed in the amputation of a calf’s forelimb

Background: Locoregional anesthesia techniques enable the performance of procedures in the distal portion of the limbs,through the parenteral administration of local anesthetic nerve block. There are devices that can increase the effectivenessof these blocks by accurately locating the nerves. These devices include peripheral nerve stimulators, which enable anesthetic to be injected near the plexus, thus reducing the volume of anesthetic required and allowing for the specific blockadeof a nerve branch by desensitizing exclusively the area of interest. This paper describes the use of nerve stimulator in thebrachial plexus block (BPB) of a calf subjected to amputation of the left foreleg.Case: A newborn calf weighing 30 kg, with a history of injury to the left foreleg, was treated at the Veterinary Hospital ofthe Federal Rural University of the Semi-Arid Region. Clinical and X-ray examinations revealed a fracture in the medialportion of the metacarpus and radiographic alterations indicative of osteomyelitis, so amputation of the affected limb wasrecommended. Prior the beginning, during and after the surgical procedure, the animal was submitted to the evaluation ofits physiological parameters (heart and respiratory rate, capillary refill time, diastolic, systolic and mean blood pressure andrectal temperature). Because it is a newborn animal, it was decided not to pre-operatively fast. After applying preanestheticmedication (xylazine 0.01 mg/kg IV), anesthesia was induced with ketamine (2 mg/kg IV) and midazolam (0.3 mg/kg IV)and maintained with isoflurane. For the brachial plexus block, 0.4 mL/kg (1.5 mg/kg) of 0.375% bupivacaine was usedand aided by a peripheral nerve stimulator to generate 10 mA current, 1 HZ frequency and 100 μs pulse duration, coupledto a nerve stimulation needle, it was possible to observe flexion movements...

Bloqueio de plexo braquial guiado por neuroestimulador para amputação em bezerro / Nerve stimulator-guided brachial plexus block performed in the amputation of a calfs forelimb

Background: Locoregional anesthesia techniques enable the performance of procedures in the distal portion of the limbs,through the parenteral administration of local anesthetic nerve block. There are devices that can increase the effectivenessof these blocks by accurately locating the nerves. These devices include peripheral nerve stimulators, which enable anesthetic to be injected near the plexus, thus reducing the volume of anesthetic required and allowing for the specific blockadeof a nerve branch by desensitizing exclusively the area of interest. This paper describes the use of nerve stimulator in thebrachial plexus block (BPB) of a calf subjected to amputation of the left foreleg.Case: A newborn calf weighing 30 kg, with a history of injury to the left foreleg, was treated at the Veterinary Hospital ofthe Federal Rural University of the Semi-Arid Region. Clinical and X-ray examinations revealed a fracture in the medialportion of the metacarpus and radiographic alterations indicative of osteomyelitis, so amputation of the affected limb wasrecommended. Prior the beginning, during and after the surgical procedure, the animal was submitted to the evaluation ofits physiological parameters (heart and respiratory rate, capillary refill time, diastolic, systolic and mean blood pressure andrectal temperature). Because it is a newborn animal, it was decided not to pre-operatively fast. After applying preanestheticmedication (xylazine 0.01 mg/kg IV), anesthesia was induced with ketamine (2 mg/kg IV) and midazolam (0.3 mg/kg IV)and maintained with isoflurane. For the brachial plexus block, 0.4 mL/kg (1.5 mg/kg) of 0.375% bupivacaine was usedand aided by a peripheral nerve stimulator to generate 10 mA current, 1 HZ frequency and 100 μs pulse duration, coupledto a nerve stimulation needle, it was possible to observe flexion movements...(AU)