Carcinoma tubulopapilífero em porquinho-da- índia (Cavia porcellus): relato de caso / Tubulopapilliferous carcinoma in guinea pig (Cavia porcellus): case report

Os roedores são pets comuns nas residências das pessoas, dentre os quais destacam-se o porquinho-da-índia, rato twister e a cobaia doméstica como animais de estimação populares na atualidade. Dentre as enfermidades que podem acometer esses animais estão as diferentes categorias de neoplasias, sobre as quais existem poucos estudos e relatos publicados. Tendo isso em mente, percebe-se a necessidade de incentivar pesquisas sobre o tema, visto que o estudo de neoplasias em roedores pode fornecer informações a respeito das causas e formas de tratamento do câncer não só para estes animais, mas também para outras espécies, incluindo seres humanos. Diante do cenário exposto, o presente artigo tem como objetivo relatar um caso de carcinoma tubulopapilífero em um porquinho-da-índia (Cavia porcellus) atendido no Hospital Veterinário da Universidade de Sorocaba (HOVET/UNISO). Após a retirada cirúrgica da neoplasia o paciente recuperou bem e recebeu alta veterinária.

Rodents are common pets in people's homes, among which the guinea pig, twister rat and domestic guinea pig stand out as popular pets today. Among the diseases that can affect these animals are the different categories of neoplasms, on which there are few studies and published reports. With this in mind, there is a need to encourage research on the subject, since the study of neoplasms in rodents can provide information about the causes and forms of cancer treatment not only for these animals, but also for other species, including humans. In view of the above scenario, this article aims to report a case of tubulopapillary carcinoma in a guinea pig (Cavia porcellus) treated at the Veterinary Hospital of the University of Sorocaba (HOVET /UNISO). After surgical removal of the neoplasm, the patient recovered well and was discharged from the veterinary hospital.

Primary nonlymphoid gastrointestinal neoplasms in dogs in Rio Grande do Sul / Neoplasmas gastrointestinais primários não linfoides em cães no Rio Grande do Sul

Gastrointestinal neoplasms (GIN) are uncommon in dogs, but they mainly show malignant behavior and poor prognosis. The types of GIN in dogs and their frequency, as well as their epidemiological and histopathological characteristics were analyzed through a retrospective study of biopsies from 24.711 dogs from 2005 to 2017. Additionally, histological sections of neoplasms were subjected to immunohistochemistry (IHC) using antibodies against pancytokeratin, vimentin, smooth muscle actin, c-Kit, S-100, CD31, CD79αcy, and neuron-specific enolase. Of the total samples from dogs analyzed, 88 corresponded to GIN. Neoplasms occurred more frequently in purebred dogs (64.8%, 57/88), males (53.4%, 47/88), with a median age of 10 years. The intestine was affected by 84.1% (74/88) of the cases. Of these, the large intestine was the most affected (67.6%, 50/74). Most of the neoplasms had malignant behavior (88.6%, 78/88). Regarding the classification of neoplasms, 46.6% (41/88) of the diagnoses corresponded to epithelial, 46.6% (41/88) were mesenchymal, 5.7% (5/88) were hematopoietic, and 1.1% (1/88) was neuroendocrine. The most frequently diagnosed neoplasms were papillary adenocarcinoma (19.3%, 17/88), leiomyosarcoma (17.0%, 15/88), gastrointestinal stromal tumors (GISTs) (12.5%, 11/88), and leiomyoma (5.0%, 8/88). Adenocarcinomas were located mainly in the rectum, whereas leiomyosarcomas and GISTs developed mainly in the cecum. Epithelial neoplasms showed a greater potential for lymphatic invasion whereas mesenchymal neoplasms appeared to be more expansive with intratumoral necrosis and hemorrhage. Immunohistochemistry was found to be an important diagnostic technique for the identification of infiltrating cells in carcinomas and an indispensable technique for the definitive diagnosis of sarcomas.(AU)

Neoplasmas gastrointestinais (NGI) são pouco comuns em cães, mas possuem principalmente comportamento maligno e prognóstico reservado. Os tipos de NGI em cães e sua frequência, bem como características epidemiológicas e histopatológicas foram analisados por meio de um estudo retrospectivo dos exames de biópsias de 24.711 cães entre os anos de 2005 a 2017. Adicionalmente, cortes histológicos de NGI foram submetidos à técnica de imuno-histoquímica (IHQ), utilizando os anticorpos anti-pancitoqueratina, vimentina, actina de músculo liso, c-Kit, S-100, CD31, CD79αcy e enolase neurônio específica. Do total de cães analisados, 88 corresponderam a NGI não linfoides. Os neoplasmas ocorreram com maior frequência em cães de raça pura (64,8%, 57/88), machos (53,4%, 47/88), com mediana de idade de 10 anos. O intestino foi acometido em 84,1% dos casos (74/88). Destes, o intestino grosso foi o segmento mais afetado (67,6%, 50/74). A maior parte dos neoplasmas tinha comportamento maligno (88,6%, 78/88). Quanto à classificação, 46,6% (41/88) dos diagnósticos corresponderam a neoplasmas epiteliais, 46,6% (41/88) mesenquimais, 5,7% (5/88) hematopoiéticos e 1,1% (1/88), neuroendócrino. Os neoplasmas mais frequentemente diagnosticados foram adenocarcinoma papilar (19,3%, 17/88), leiomiossarcoma (17,0%, 15/88), tumor estromal gastrointestinal (GIST) (12,5%, 11/88) e leiomioma (12,5%, 8/88). Adenocarcinomas localizavam-se principalmente no reto, enquanto leiomiossarcoma e GISTs desenvolveram-se principalmente no ceco. Os neoplasmas epiteliais demonstraram um potencial maior de invasão linfática enquanto que os mesenquimais aparentaram ser mais expansivos, com necrose e hemorragia intratumorais. A imuno-histoquímica mostrou ser uma técnica diagnóstica importante para a identificação de células neoplásicas infiltravas no caso dos carcinomas e uma técnica indispensável para o diagnóstico definitivo de sarcomas.(AU)

Primary nonlymphoid gastrointestinal neoplasms in dogs in Rio Grande do Sul / Neoplasmas gastrointestinais primários não linfoides em cães no Rio Grande do Sul

Gastrointestinal neoplasms (GIN) are uncommon in dogs, but they mainly show malignant behavior and poor prognosis. The types of GIN in dogs and their frequency, as well as their epidemiological and histopathological characteristics were analyzed through a retrospective study of biopsies from 24.711 dogs from 2005 to 2017. Additionally, histological sections of neoplasms were subjected to immunohistochemistry (IHC) using antibodies against pancytokeratin, vimentin, smooth muscle actin, c-Kit, S-100, CD31, CD79αcy, and neuron-specific enolase. Of the total samples from dogs analyzed, 88 corresponded to GIN. Neoplasms occurred more frequently in purebred dogs (64.8%, 57/88), males (53.4%, 47/88), with a median age of 10 years. The intestine was affected by 84.1% (74/88) of the cases. Of these, the large intestine was the most affected (67.6%, 50/74). Most of the neoplasms had malignant behavior (88.6%, 78/88). Regarding the classification of neoplasms, 46.6% (41/88) of the diagnoses corresponded to epithelial, 46.6% (41/88) were mesenchymal, 5.7% (5/88) were hematopoietic, and 1.1% (1/88) was neuroendocrine. The most frequently diagnosed neoplasms were papillary adenocarcinoma (19.3%, 17/88), leiomyosarcoma (17.0%, 15/88), gastrointestinal stromal tumors (GISTs) (12.5%, 11/88), and leiomyoma (5.0%, 8/88). Adenocarcinomas were located mainly in the rectum, whereas leiomyosarcomas and GISTs developed mainly in the cecum. Epithelial neoplasms showed a greater potential for lymphatic invasion whereas mesenchymal neoplasms appeared to be more expansive with intratumoral necrosis and hemorrhage. Immunohistochemistry was found to be an important diagnostic technique for the identification of infiltrating cells in carcinomas and an indispensable technique for the definitive diagnosis of sarcomas.(AU)

Neoplasmas gastrointestinais (NGI) são pouco comuns em cães, mas possuem principalmente comportamento maligno e prognóstico reservado. Os tipos de NGI em cães e sua frequência, bem como características epidemiológicas e histopatológicas foram analisados por meio de um estudo retrospectivo dos exames de biópsias de 24.711 cães entre os anos de 2005 a 2017. Adicionalmente, cortes histológicos de NGI foram submetidos à técnica de imuno-histoquímica (IHQ), utilizando os anticorpos anti-pancitoqueratina, vimentina, actina de músculo liso, c-Kit, S-100, CD31, CD79αcy e enolase neurônio específica. Do total de cães analisados, 88 corresponderam a NGI não linfoides. Os neoplasmas ocorreram com maior frequência em cães de raça pura (64,8%, 57/88), machos (53,4%, 47/88), com mediana de idade de 10 anos. O intestino foi acometido em 84,1% dos casos (74/88). Destes, o intestino grosso foi o segmento mais afetado (67,6%, 50/74). A maior parte dos neoplasmas tinha comportamento maligno (88,6%, 78/88). Quanto à classificação, 46,6% (41/88) dos diagnósticos corresponderam a neoplasmas epiteliais, 46,6% (41/88) mesenquimais, 5,7% (5/88) hematopoiéticos e 1,1% (1/88), neuroendócrino. Os neoplasmas mais frequentemente diagnosticados foram adenocarcinoma papilar (19,3%, 17/88), leiomiossarcoma (17,0%, 15/88), tumor estromal gastrointestinal (GIST) (12,5%, 11/88) e leiomioma (12,5%, 8/88). Adenocarcinomas localizavam-se principalmente no reto, enquanto leiomiossarcoma e GISTs desenvolveram-se principalmente no ceco. Os neoplasmas epiteliais demonstraram um potencial maior de invasão linfática enquanto que os mesenquimais aparentaram ser mais expansivos, com necrose e hemorragia intratumorais. A imuno-histoquímica mostrou ser uma técnica diagnóstica importante para a identificação de células neoplásicas infiltravas no caso dos carcinomas e uma técnica indispensável para o diagnóstico definitivo de sarcomas.(AU)

Adenocarcinoma renal papilar em um cão - relato de caso / Papillar renal adenocarcinoma in a dog - case report

O trabalho teve como objetivo relatar um caso de adenocarcinoma renal papilar em um cão macho da raça labrador. O animal foi atendido em uma clínica veterinária de Campo Mourão – PR, com queixa principal de hematúria e perda de peso durante quatro meses. No exame físico o animal apresentou aumento de volume intra-abdominal localizado, de consistência firme e desconforto abdominal à palpação. No exame ultrassonográfico, evidenciou-se a presença de cristais, e pequenos cálculos vesicais urinários, inflamação da parede da vesícula urinária e visualizado uma massa localizada em quadrante abdominal caudal esquerdo em região mesogástrica de difícil delimitação e possivelmente envolvendo o rim esquerdo. Foi realizado o procedimento de laparotomia exploratória e na inspeção da cavidade observou-se significativo aumento de volume do rim esquerdo, realizando o procedimento de nefrectomia unilateral esquerda. Uma amostra deste rim foi enviada para análise histopatológica a um Laboratório de Patologia Animal. Nesta avaliação foram observadas células neoplásicas, características por serem poliédricas e exibirem núcleo grande oval, citoplasma pouco abundante eosinofílico, formam estruturas tubulares e projeções intraluminais papiliformes irregulares. O índice mitótico é de 1 – 2 fm./ 40x, observa-se também desmoplasia foco de necrose tumoral, sendo conclusivo de adenocarcinoma renal papilar. Conclui-se que o exame histopatológico é de suma importância para o diagnóstico desta neoplasia. E o adenocarcinoma renal papilar causa uma lesão grave no rim, podendo ocorrer metástase para outros órgãos e levar o animal a morte.

This study aimed to report a case of papillary renal adenocarcinoma in a male labrador dog. The animal was treated at a veterinary clinic in Campo Mourão - PR, with the main complaint of hematuria and weight loss for four months. On physical examination the animal showed localized intra-abdominal volume increase, firm consistency and abdominal discomfort on palpation. The ultrasound examination evinced the presence of crystals, and small urinary bladder stones, inflammation of the urinary bladder wall and it was visualized a mass located in the left caudal abdominal quadrant in the mesogastric region, hardly delimited and possibly involving the left kidney. Exploratory laparotomy and cavity inspection were performed, which significantly increased the volume of the left kidney, performing the left unilateral nephrectomy procedure. A sample of this kidney was sent for histopathological analysis at the Animal Pathology Laboratory. In this evaluation, neoplastic cells, polymer resources and large oval nucleus display, sparse eosinophilic cytoplasm, tubular forms and irregular papilliform intraluminal projections were observed. The mitotic index is 1 - 2 fm./40x, as well as focal desmoplasia of tumor necrosis. Being conclusive of renal papillary adenocarcinoma. To conclude that histopathological examination is extremely important for the diagnosis of this neoplasia. And renal papillary adenocarcinoma causes severe kidney damage, metastasis to other organs can lead to death.

Tubulopapillary carcinoma of the mammary gland in a mare

Background: Mammary gland neoplasia are often observed in bitches and cats, rarely in cows, goats, sheep, sows, andmares. Among the neoplasia that affect mares, breast tumors are rare, as they occur more frequently in older animals. Inhorses, mammary gland tumors occur more frequently in older animals. In this species there are reports of cases describingcarcinomas and adenocarcinomas and several subtypes. Mammary neoplasms in equines tend to be locally aggressive andpromote metastases to the regional lymph nodes and other organs, including the lungs, and may cause pleural effusion.The aim objective of the present case report was to describe the clinical-pathological and immunohistochemical findingsof a tubulopapillary carcinoma of the mammary gland in mare.Case: Was received a biopsy of a tumor mass of the mammary gland of a 15-year-old Quarter Horse mare. According tothe veterinarian, the mare presented an increase in volume with ulceration of the mammary gland three months before thebiopsy. Macroscopically, the mass was firm to the cut with white surface measuring 12x12 cm. The fragment was fixedin 10% formalin, routinely processed for histology, paraffin embedded, and stained with hematoxylin and eosin. Microscopically, we observed proliferation of epithelial neoplastic cells arranged in tubules and papillary projections, somewith two to three layers of cells. Neoplastic cells had oval, moderate and distinct cytoplasm. The nuclei were roundedwith dense chromatin and an apparent nucleolus. There were two figures of mitosis per field of high magnification. Proliferation of neoplastic cells invaded adjacent tissues, and in lymph vessels of the region, neoplastic cells were observedas well as inflammation in adjacent tissue. In addition, the breast fragment was submitted to the immunohistochemistrytechnique using anti-pancytokeratin and anti-vimentin antibody. In immunohistochemistry for pancytokeratin, there wasimmunoreactivity...

Tubulopapillary carcinoma of the mammary gland in a mare

Background: Mammary gland neoplasia are often observed in bitches and cats, rarely in cows, goats, sheep, sows, andmares. Among the neoplasia that affect mares, breast tumors are rare, as they occur more frequently in older animals. Inhorses, mammary gland tumors occur more frequently in older animals. In this species there are reports of cases describingcarcinomas and adenocarcinomas and several subtypes. Mammary neoplasms in equines tend to be locally aggressive andpromote metastases to the regional lymph nodes and other organs, including the lungs, and may cause pleural effusion.The aim objective of the present case report was to describe the clinical-pathological and immunohistochemical findingsof a tubulopapillary carcinoma of the mammary gland in mare.Case: Was received a biopsy of a tumor mass of the mammary gland of a 15-year-old Quarter Horse mare. According tothe veterinarian, the mare presented an increase in volume with ulceration of the mammary gland three months before thebiopsy. Macroscopically, the mass was firm to the cut with white surface measuring 12x12 cm. The fragment was fixedin 10% formalin, routinely processed for histology, paraffin embedded, and stained with hematoxylin and eosin. Microscopically, we observed proliferation of epithelial neoplastic cells arranged in tubules and papillary projections, somewith two to three layers of cells. Neoplastic cells had oval, moderate and distinct cytoplasm. The nuclei were roundedwith dense chromatin and an apparent nucleolus. There were two figures of mitosis per field of high magnification. Proliferation of neoplastic cells invaded adjacent tissues, and in lymph vessels of the region, neoplastic cells were observedas well as inflammation in adjacent tissue. In addition, the breast fragment was submitted to the immunohistochemistrytechnique using anti-pancytokeratin and anti-vimentin antibody. In immunohistochemistry for pancytokeratin, there wasimmunoreactivity...(AU)

Adenocarcinoma renal papilar em um cão - relato de caso / Papillar renal adenocarcinoma in a dog - case report

O trabalho teve como objetivo relatar um caso de adenocarcinoma renal papilar em um cão macho da raça labrador. O animal foi atendido em uma clínica veterinária de Campo Mourão PR, com queixa principal de hematúria e perda de peso durante quatro meses. No exame físico o animal apresentou aumento de volume intra-abdominal localizado, de consistência firme e desconforto abdominal à palpação. No exame ultrassonográfico, evidenciou-se a presença de cristais, e pequenos cálculos vesicais urinários, inflamação da parede da vesícula urinária e visualizado uma massa localizada em quadrante abdominal caudal esquerdo em região mesogástrica de difícil delimitação e possivelmente envolvendo o rim esquerdo. Foi realizado o procedimento de laparotomia exploratória e na inspeção da cavidade observou-se significativo aumento de volume do rim esquerdo, realizando o procedimento de nefrectomia unilateral esquerda. Uma amostra deste rim foi enviada para análise histopatológica a um Laboratório de Patologia Animal. Nesta avaliação foram observadas células neoplásicas, características por serem poliédricas e exibirem núcleo grande oval, citoplasma pouco abundante eosinofílico, formam estruturas tubulares e projeções intraluminais papiliformes irregulares. O índice mitótico é de 1 2 fm./ 40x, observa-se também desmoplasia foco de necrose tumoral, sendo conclusivo de adenocarcinoma renal papilar. Conclui-se que o exame histopatológico é de suma importância para o diagnóstico desta neoplasia. E o adenocarcinoma renal papilar causa uma lesão grave no rim, podendo ocorrer metástase para outros órgãos e levar o animal a morte.(AU)

This study aimed to report a case of papillary renal adenocarcinoma in a male labrador dog. The animal was treated at a veterinary clinic in Campo Mourão - PR, with the main complaint of hematuria and weight loss for four months. On physical examination the animal showed localized intra-abdominal volume increase, firm consistency and abdominal discomfort on palpation. The ultrasound examination evinced the presence of crystals, and small urinary bladder stones, inflammation of the urinary bladder wall and it was visualized a mass located in the left caudal abdominal quadrant in the mesogastric region, hardly delimited and possibly involving the left kidney. Exploratory laparotomy and cavity inspection were performed, which significantly increased the volume of the left kidney, performing the left unilateral nephrectomy procedure. A sample of this kidney was sent for histopathological analysis at the Animal Pathology Laboratory. In this evaluation, neoplastic cells, polymer resources and large oval nucleus display, sparse eosinophilic cytoplasm, tubular forms and irregular papilliform intraluminal projections were observed. The mitotic index is 1 - 2 fm./40x, as well as focal desmoplasia of tumor necrosis. Being conclusive of renal papillary adenocarcinoma. To conclude that histopathological examination is extremely important for the diagnosis of this neoplasia. And renal papillary adenocarcinoma causes severe kidney damage, metastasis to other organs can lead to death.(AU)

Papillary Adenocarcinoma of the descending colon in a dog: case report / Adenocarcinoma papilífero em cólon descendente de cão: relato de caso

The aim of this report was to describe the clinical findings and therapeutic management of a case of papillary adenocarcinoma of the descending colon in a Beagle. The patient presented soft stools, haematochezia, tenesmus, and dyschezia. Clinical examination revealed alterations on the ultrasonographic features of the descending colon suggestive of colitis and neoplasia. Following local mass resection, histopathology analysis revealed mild lymphoplasmocytic enteritis and papillary adenocarcinoma of the colon. Enterectomy for tumoral resection and biopsy of locoregional lymph nodes were carried out. Subsequent to the surgical procedure, it was possible to confirm the previous diagnosis and the tumor was classified as intestinal intraluminal papillary adenocarcinoma, with incomplete surgical margins. Adjuvant chemotherapy was performed using carboplatin, cyclophosphamide, and piroxicam, leading to remission of clinical signs and absence of any clinical or imaging alterations compatible with the patient's previous clinical condition.(AU)

O objetivo desse relato de caso foi descrever os achados clínicos e manejo terapêutico de um caso de adenocarcinoma papilífero do cólon descendente em um Beagle. O paciente apresentou fezes amolecidas, hematoquesia, tenesmo e disquesia. Exame clínico revelou alteração de achados ultrassonográficos do cólon descendente sugerindo colite e neoplasia. Após ressecção de massa local, análise histopatológica revelou enterite linfmoplasmocito leve e adenocarcinoma papilar do cólon. Enterectomia para ressecção tumoral e biopsia das lesões locais e tumores linfonodais foram realizadas. Após procedimento cirúrgico foi possível confirmar o diagnóstico prévio e o tumor foi classificado como adenocarcinoma papilar intraluminal intestinal, com margens cirúrgicas incompletas. Quimioterapia adjuvante foi realizada utilizando carboplatina, ciclofosfamida e piroxano, levando a remissão de sinais clínicos e ausência de alterações de imagem compatíveis com situação clínica prévia do paciente.(AU)

Papillary Adenocarcinoma of the descending colon in a dog: case report / Adenocarcinoma papilífero em cólon descendente de cão: relato de caso

The aim of this report was to describe the clinical findings and therapeutic management of a case of papillary adenocarcinoma of the descending colon in a Beagle. The patient presented soft stools, haematochezia, tenesmus, and dyschezia. Clinical examination revealed alterations on the ultrasonographic features of the descending colon suggestive of colitis and neoplasia. Following local mass resection, histopathology analysis revealed mild lymphoplasmocytic enteritis and papillary adenocarcinoma of the colon. Enterectomy for tumoral resection and biopsy of locoregional lymph nodes were carried out. Subsequent to the surgical procedure, it was possible to confirm the previous diagnosis and the tumor was classified as intestinal intraluminal papillary adenocarcinoma, with incomplete surgical margins. Adjuvant chemotherapy was performed using carboplatin, cyclophosphamide, and piroxicam, leading to remission of clinical signs and absence of any clinical or imaging alterations compatible with the patient's previous clinical condition.(AU)

O objetivo desse relato de caso foi descrever os achados clínicos e manejo terapêutico de um caso de adenocarcinoma papilífero do cólon descendente em um Beagle. O paciente apresentou fezes amolecidas, hematoquesia, tenesmo e disquesia. Exame clínico revelou alteração de achados ultrassonográficos do cólon descendente sugerindo colite e neoplasia. Após ressecção de massa local, análise histopatológica revelou enterite linfmoplasmocito leve e adenocarcinoma papilar do cólon. Enterectomia para ressecção tumoral e biopsia das lesões locais e tumores linfonodais foram realizadas. Após procedimento cirúrgico foi possível confirmar o diagnóstico prévio e o tumor foi classificado como adenocarcinoma papilar intraluminal intestinal, com margens cirúrgicas incompletas. Quimioterapia adjuvante foi realizada utilizando carboplatina, ciclofosfamida e piroxano, levando a remissão de sinais clínicos e ausência de alterações de imagem compatíveis com situação clínica prévia do paciente.(AU)

Thoracotomy with rib resection for pulmonary lobectomy for a big primary papillary adenocarcinoma in dog / Toracotomia com ressecção de costela para lobectomia pulmonar de adenocarcinoma papilar primário extenso em cão

Background: Primary pulmonary neoplasms are uncommon in dogs. The thoracotomy for resection of rib procedure is performed still little in the national territory in small animal medicine and may in some cases of large tumors the best indication. In this context, the aim of this study was to report the clinical, pathological and histological features, as well to describe the pulmonary lobectomy with rib resection as a therapeutic option for a big pulmonary papillary adenocarcinoma in a dog. Case: A Sixteen-years-old female dachshund dog was referred had a history of cough for about two months. In physical examination expiratory dyspnea, abdominal breathing and muffled lung sounds (mainly in the left lower lung field) was observed. In the chest radiograph a radiopaque structure (9.5 x 7.5 cm) was visualized in the left lower lobe and the trachea was shifted to the right. Front to the findings, the animal was referred for thoracotomy with rib resection to lobectomy of the left lower lobe. In surgery, was performed incision skin/musculocutaneous parallel to the seventh left rib extending from the proximity of the costovertebral articulation to the sternum. After incision and dissection of the muscle layer, the periosteum of the seventh rib was incised on the lateral surface of the middle rib. Then sectioned rib with shear and periosteum together with the parietal pleura with the...(AU)

Thoracotomy with rib resection for pulmonary lobectomy for a big primary papillary adenocarcinoma in dog / Toracotomia com ressecção de costela para lobectomia pulmonar de adenocarcinoma papilar primário extenso em cão

Background: Primary pulmonary neoplasms are uncommon in dogs. The thoracotomy for resection of rib procedure is performed still little in the national territory in small animal medicine and may in some cases of large tumors the best indication. In this context, the aim of this study was to report the clinical, pathological and histological features, as well to describe the pulmonary lobectomy with rib resection as a therapeutic option for a big pulmonary papillary adenocarcinoma in a dog. Case: A Sixteen-years-old female dachshund dog was referred had a history of cough for about two months. In physical examination expiratory dyspnea, abdominal breathing and muffled lung sounds (mainly in the left lower lung field) was observed. In the chest radiograph a radiopaque structure (9.5 x 7.5 cm) was visualized in the left lower lobe and the trachea was shifted to the right. Front to the findings, the animal was referred for thoracotomy with rib resection to lobectomy of the left lower lobe. In surgery, was performed incision skin/musculocutaneous parallel to the seventh left rib extending from the proximity of the costovertebral articulation to the sternum. After incision and dissection of the muscle layer, the periosteum of the seventh rib was incised on the lateral surface of the middle rib. Then sectioned rib with shear and periosteum together with the parietal pleura with the...

Carcinoma mamário em égua: achados clínicos e histopatológicos / Mammary carcinoma in a mare: clinical and histopathological findings

Uma égua da raça Quarto-de-Milha, doadora de embriões, de vinte e três anos de idade foi atendida no Departamento de Reprodução Animal e Radiologia Veterinária da FMVZ - UNESP - Botucatu, apresentando uma massa ulcerada, de consistência firme, drenando secreção serosanguinolenta, medindo 15cm x 16cm x 14,8cm na mama direita. O exame citológico foi inconclusivo devido à baixa celularidade e predomínio de células inflamatórias. Foi realizada mastectomia unilateral e exame histopatológico que revelaram um carcinoma mamário túbulo-papilífero, com extensivo acometimento intralobular e intraductal, estroma abundante e infiltrado inflamatório polimorfonuclear acentuado e difuso. Este trabalho tem como objetivo relatar os achados clínico e histopatológicos de um caso de carcinoma mamário túbulo-papilífero em uma égua, confirmando a importância do exame citológico e histopatológico no diagnóstico diferencial de processos inflamatórios e neoplásicos.

A twenty three years old quarter horse mare, embryo donor, was attended at the Veterinary Radiology and Animal Reproduction Department - FMVZ - UNESP - Botucatu, showing an ulcerated, firm consistency mass, draining a serosanguineous secretion, measuring 15cm X 16cm X 14,8cm in the right udder. The cytological exam was inconclusive due to a low celularity and prevalence of inflammatory cells. An unilateral mastectomy and histopathological exam were performed, which revealed a tubulo-papillary mammary carcinoma, with extensive intralobular and intraductal involvement, with profuse stroma and marked and diffuse polymorphonuclear inflammatory infiltrate. The aim of this work is to describe the clinical and histopathological findings of a tubulo-papillary mammary carcinoma in a mare and affirm the importance of the histopathological and cytological exams on the differential diagnosis of neoplasms and inflammatory processes.