Anaphylactic shock with pulmonary eosinophilic infiltration due to honeybee attack in a donkey: case report / [Choque anafilático com infiltração eosinófila pulmonar devido a ataque de abelhas em um burro: relato de caso]

A case of a donkey attacked by Africanized honeybee is reported here with clinical signs of agitation, dehydration, congestion of the ocular mucous membranes, tongue edema, tachycardia and inspiratory dyspnea, and progression to death. At necropsy, diffuse, severe subcutaneous edema at face and cervical regions and severe diffuse pulmonary hyperemia with abundant edema without parenchymal collapse were observed. Microscopically, marked, diffuse deep dermis and panniculus carnosus edema and marked diffuse alveolar edema, with moderate population of eosinophils predominantly around larger caliber vessels were noted. The final diagnosis of anaphylactic shock was supported by history, clinical signs, and anatomic pathology findings. This is the first report of a honeybee attack with pulmonary eosinophilic infiltration in a mammal.(AU)

Descreve-se um caso de ataque de abelha africanizada em um burro, com sinais clínicos de agitação, desidratação, mucosas oculares congestas, edema de língua, taquicardia e dispneia inspiratória, com progressão e morte. Na necropsia, foram verificados edema subcutâneo difuso grave nas regiões de face e cervical, hiperemia pulmonar difusa grave com edema abundante e sem colapso do parênquima. Microscopicamente, foram observados edema marcado difuso na derme profunda e panículo carnoso e edema alveolar difuso acentuado, com população moderada de eosinófilos predominantemente em torno de vasos de maior calibre. O diagnóstico de choque anafilático foi baseado no histórico, em sinais clínicos e em achados anatomopatológicos. Este é o primeiro relato de ataque de abelhas com infiltração eosinofílica pulmonar em um mamífero.(AU)

Acidentes botrópicos em cães / Bothrops snakebites in dogs

Background: Snakebites occur frequently among humans and animals. In Brazil, about 23,000 cases of snakebite involving humans were recorded in 2016, 11% of them caused by venomous snakes. In the region of Cuiabá, capital of MatoGrosso, the highest occurrence is of snakes of the genus Bothrops (81%), followed by Crotalus (4%). Bothrops venom hasproteolytic, coagulant, and hemorrhagic effects, whereas Crotalus venom is neurotoxic, myotoxic and nephrotoxic. Thispaper reports on three cases of Bothrops snakebites in dogs treated at the Veterinary Hospital of the Federal Universityof Mato Grosso in 2017.Cases: Three dogs were treated showing clinical signs of snakebite, possibly by Bothrops, since their owners reportedthat these are the snakes most frequently found where they live. This information is consistent with the known geographicdistribution of snakes of the genus Bothrops in the state of Mato Grosso, Brazil. In the first report (Case 11), the patientwas bitten on two different occasions in a five-month interval, and died presumably due to anaphylactic shock causedby the venom injected by a second snakebite (Case 12). In both episodes, the animal presented a swollen face and neck,dyspnea and eye bleeding, and these signs were more severe in the second episode. Case 2 was a dog with severe neckand chest swelling and pain. The owner of this dog reported that he had taken his dog for a walk in the countryside, alongwith the dog of Case 1, and had returned home with both dogs about three hours before the consultation. Case 3 was aRottweiler living at a small family farm located 67 km from Cuiabá. The animal presented slight swelling and pain in theleft forelimb, and puncture wounds on the lower limb. Neutrophilic leukocytosis was observed in cases 1 and 3. In addition, Case 12 (the second episode of Case 1) presented thrombocytopenia and increased prothrombin time and activatedpartial...

Acidentes botrópicos em cães / Bothrops snakebites in dogs

Background: Snakebites occur frequently among humans and animals. In Brazil, about 23,000 cases of snakebite involving humans were recorded in 2016, 11% of them caused by venomous snakes. In the region of Cuiabá, capital of MatoGrosso, the highest occurrence is of snakes of the genus Bothrops (81%), followed by Crotalus (4%). Bothrops venom hasproteolytic, coagulant, and hemorrhagic effects, whereas Crotalus venom is neurotoxic, myotoxic and nephrotoxic. Thispaper reports on three cases of Bothrops snakebites in dogs treated at the Veterinary Hospital of the Federal Universityof Mato Grosso in 2017.Cases: Three dogs were treated showing clinical signs of snakebite, possibly by Bothrops, since their owners reportedthat these are the snakes most frequently found where they live. This information is consistent with the known geographicdistribution of snakes of the genus Bothrops in the state of Mato Grosso, Brazil. In the first report (Case 11), the patientwas bitten on two different occasions in a five-month interval, and died presumably due to anaphylactic shock causedby the venom injected by a second snakebite (Case 12). In both episodes, the animal presented a swollen face and neck,dyspnea and eye bleeding, and these signs were more severe in the second episode. Case 2 was a dog with severe neckand chest swelling and pain. The owner of this dog reported that he had taken his dog for a walk in the countryside, alongwith the dog of Case 1, and had returned home with both dogs about three hours before the consultation. Case 3 was aRottweiler living at a small family farm located 67 km from Cuiabá. The animal presented slight swelling and pain in theleft forelimb, and puncture wounds on the lower limb. Neutrophilic leukocytosis was observed in cases 1 and 3. In addition, Case 12 (the second episode of Case 1) presented thrombocytopenia and increased prothrombin time and activatedpartial...(AU)

Evaluation of physiological parameters of dogs submitted to uterine lymphatic mapping using patent blue V dye for anaphylaxis detection / Avaliação de parâmetros fisiológicos de cães submetidos ao mapeamento linfático uterino usando o corante azul patente V para a detecção de anafilaxia

Lymphatic mapping has been performed in humans and dogs. Although several cases of anaphylaxis have been reported in humans, there are no such reports in dogs. The objective of this study was to identify the occurrence of adverse reactions to patent blue V dye in bitches undergoing uterine lymphatic mapping procedures using cardiovascular and hematological evaluations. The experiment was performed in 14 mongrel bitches without any reproductive disease, randomly assigned into two equal groups (PBV- uterine lynphatic mapping and OHE; Control - OHE only). The animals were submitted to pre- and postoperative hematological and serum biochemistry exams (7 days). The anesthetic protocol was: sedation (morphine and acepromazine), induction (propofol), maintenance (isoflurane), transoperative analgesia (fentanyl). Systolic blood pressure was monitored throughout the procedure and arterial blood gas analysis was performed immediate pre and postoperatively. For lymphatic mapping was injected patent blue V in the uterine wall, 10 minutes before OEH. Comparisons between the pre- and postoperative parameters within the same animal were performed using the Wilcoxon-Mann-Whitney test. To compare the values between control and PBV group was obtaining the difference between the pre and post of each group, subjected to the Mann-Whitney test (significance of 5%). Differences were observed (P<0.05) between the pre- and postoperative evaluations in the PBV (total protein and the albumin serum), in both groups (arterial partial pressure of oxygen) and in the Control (arterial oxygen saturation). There were no signs of adverse reactions to the patent blue V dye in the healthy bitches submitted to lymphatic uterine mapping.(AU)

O mapeamento linfático tem sido realizado em humanos e cães. Embora inúmeros casos de anafilaxia já tenham sido relatados em humanos, não existem tais relatos em cães. O objetivo deste estudo foi identificar a ocorrência de reações adversas ao corante azul patente V em cadelas submetidas ao mapeamento linfático uterino, usando avaliações cardiovasculares e hematológicas. O experimento foi realizado em 14 cadelas mestiças, divididas igualmente em dois grupos (PBV- mapeamento linfático uterino e OEH; Controle - apenas OEH). Os animais foram submetidos a exames hematológicos e bioquímicos séricos no pré e pós-operatório (7 dias). O protocolo anestésico foi: sedação (morfina e acepromazina), indução (propofol), manutenção (isoflurano), analgesia trans-operatória (fentanil). A pressão arterial sistólica foi monitorada durante todo o procedimento e hemogasometria arterial no pré e pós-operatório imediato. Para o mapeamento linfático foi injetado azul patente V na parede uterina, 10 minutos antes de realizar a OEH. Comparações entre os valores do pré e pós-operatório do mesmo animal foram realizados pelo teste Wilcoxon-Mann-Whitney. Para a comparação dos valores entre Controle e PBV foi realizado a obtenção da diferença entre os valores pré e pós de cada grupo, submetidas ao teste de Mann-Whitney (significância de 5%). Diferenças foram observadas (p<0,05) entre as avaliações pré e pós-operatórias no PBV (proteína total e albumina), ambos os grupos (pressão parcial de oxigênio arterial) e no Controle (saturação de oxigênio arterial). Não houve sinais de reação adversa ao corante azul patente V em cadelas saudáveis submetidas ao mapeamento linfático uterino.(AU)

Evaluation of physiological parameters of dogs submitted to uterine lymphatic mapping using patent blue V dye for anaphylaxis detection / Avaliação de parâmetros fisiológicos de cães submetidos ao mapeamento linfático uterino usando o corante azul patente V para a detecção de anafilaxia

Lymphatic mapping has been performed in humans and dogs. Although several cases of anaphylaxis have been reported in humans, there are no such reports in dogs. The objective of this study was to identify the occurrence of adverse reactions to patent blue V dye in bitches undergoing uterine lymphatic mapping procedures using cardiovascular and hematological evaluations. The experiment was performed in 14 mongrel bitches without any reproductive disease, randomly assigned into two equal groups (PBV- uterine lynphatic mapping and OHE; Control - OHE only). The animals were submitted to pre- and postoperative hematological and serum biochemistry exams (7 days). The anesthetic protocol was: sedation (morphine and acepromazine), induction (propofol), maintenance (isoflurane), transoperative analgesia (fentanyl). Systolic blood pressure was monitored throughout the procedure and arterial blood gas analysis was performed immediate pre and postoperatively. For lymphatic mapping was injected patent blue V in the uterine wall, 10 minutes before OEH. Comparisons between the pre- and postoperative parameters within the same animal were performed using the Wilcoxon-Mann-Whitney test. To compare the values between control and PBV group was obtaining the difference between the pre and post of each group, subjected to the Mann-Whitney test (significance of 5%). Differences were observed (P 0.05) between the pre- and postoperative evaluations in the PBV (total protein and the albumin serum), in both groups (arterial partial pressure of oxygen) and in the Control (arterial oxygen saturation). There were no signs of adverse reactions to the patent blue V dye in the healthy bitches submitted to lymphatic uterine mapping.(AU)

O mapeamento linfático tem sido realizado em humanos e cães. Embora inúmeros casos de anafilaxia já tenham sido relatados em humanos, não existem tais relatos em cães. O objetivo deste estudo foi identificar a ocorrência de reações adversas ao corante azul patente V em cadelas submetidas ao mapeamento linfático uterino, usando avaliações cardiovasculares e hematológicas. O experimento foi realizado em 14 cadelas mestiças, divididas igualmente em dois grupos (PBV- mapeamento linfático uterino e OEH; Controle - apenas OEH). Os animais foram submetidos a exames hematológicos e bioquímicos séricos no pré e pós-operatório (7 dias). O protocolo anestésico foi: sedação (morfina e acepromazina), indução (propofol), manutenção (isoflurano), analgesia trans-operatória (fentanil). A pressão arterial sistólica foi monitorada durante todo o procedimento e hemogasometria arterial no pré e pós-operatório imediato. Para o mapeamento linfático foi injetado azul patente V na parede uterina, 10 minutos antes de realizar a OEH. Comparações entre os valores do pré e pós-operatório do mesmo animal foram realizados pelo teste Wilcoxon-Mann-Whitney. Para a comparação dos valores entre Controle e PBV foi realizado a obtenção da diferença entre os valores pré e pós de cada grupo, submetidas ao teste de Mann-Whitney (significância de 5%). Diferenças foram observadas (p 0,05) entre as avaliações pré e pós-operatórias no PBV (proteína total e albumina), ambos os grupos (pressão parcial de oxigênio arterial) e no Controle (saturação de oxigênio arterial). Não houve sinais de reação adversa ao corante azul patente V em cadelas saudáveis submetidas ao mapeamento linfático uterino.(AU)

Intoxicação por enrofloxacina em um cão da raça Pinscher Miniatura: relato de caso / Enrofloxacin poisoning in a Miniature Pinscher: a case report

Uma cadela da raça Pinscher Miniatura foi medicada pelo proprietário com enrofloxacina, na dose de 50mg/kg, uma vez ao dia, por dois dias (dose diária 10 vezes maior que a prescrita). Ao exame clínico o animal apresentou-se deprimido, em cifose lombar, hipotérmico, com mucosas pálidas, dispnéia, sialorréia, vômitos e anúria, evoluindo para parada respiratória, convulsões e coma. Foi realizado tratamento sintomático. O fluxo urinário retornou ao normal em 12 horas e as convulsões foram controladas, mas o animal permaneceu em coma, morrendo 72 horas após o início do tratamento. A necropsia e o histopatológico confirmaram insuficiência renal e hepática agudas, e choque hipovolêmico, compatível com intoxicação por enrofloxacina.(AU)

A Miniature Pinscher bitch was treated by the owner with enrofloxacin at dose of 50 mg/kg, once a day, for two days (daily dose rate 10 times greater than prescribed). Physical examination showed depression, lumbar cifosis, hipotermia, pale mucosa, dispneia, drewling, vomiting and anuria, followed by respiratory failure, seizures, and coma. Symptomatic treatment was performed, and the urinary flow returned to normal in 12 hours, and seizures were controlled. However, the animal stayed in coma, and died 72 hours after the beginning of the treatment. Acute renal and hepatic failure, and hipovolemic shock, compatible with enrofloxacin intoxication, were observed through necropsia and histopatology.(AU)