Calcinosis cutis with large extension and uncommon location in a dog

Background: Calcinosis cutis is an uncommon dermatopathy characterized by the deposition of minerals in the skin,usually involving collagen and elastic fibers in the dermis. Usually, it results from dystrophic calcification and can begeneralized or focal. The dermatopathy may be primary or secondary to certain disorders, especially chronic proliferativeotitis, foreign body reactions, hyperadrenocorticism (HAC) and less frequently percutaneous penetration of calcium-richproducts. The aim of this report is to describe a presentation of calcinosis cutis affecting the skin of the back, internal faceof hind limbs and anal region of a 9-years-old bitch.Case: A 9-year-old, non-defined breed, bitch, ovariohysterectomized, weighing 9.45 kg, was attended at the DermatologicalService of companion animals at the Veterinary Hospital of the Federal University of Jataí (UFJ). The animal came in withthe complaint of extensive dorsal alopecia, covered by firm lesions, with a 3-month evolution, additionally to polyuria andpolydipsia. After physical examination, alopecic areas of great extension were confirmed on the dorsum, on the internalsurface of the hind limbs and in the anal region. Also, an exudative and painful lesion located on the back was detected,plus loss of elasticity of the ventral abdomen skin and visible abdominal vessels. The screening tests showed a markedincrease in the alanine aminotransferase enzyme (ALT), alkaline phosphatase (ALP) and total cholesterol. The specificurinary density was decreased. On the ultrasound examination, hepatomegaly and an increase in the caudal pole of the leftadrenal were detected. Based on these findings, calcinosis cutis secondary to spontaneous hyperadrenocorticism (HAC)was suspected. For confirmation, skin biopsy and low dose dexamethasone suppression test (LDDS) were performed.LDDS test showed no reduction of serum cortisol after 8 h of dexamethasone dose administration and histopathological...

Calcinosis cutis with large extension and uncommon location in a dog

Background: Calcinosis cutis is an uncommon dermatopathy characterized by the deposition of minerals in the skin,usually involving collagen and elastic fibers in the dermis. Usually, it results from dystrophic calcification and can begeneralized or focal. The dermatopathy may be primary or secondary to certain disorders, especially chronic proliferativeotitis, foreign body reactions, hyperadrenocorticism (HAC) and less frequently percutaneous penetration of calcium-richproducts. The aim of this report is to describe a presentation of calcinosis cutis affecting the skin of the back, internal faceof hind limbs and anal region of a 9-years-old bitch.Case: A 9-year-old, non-defined breed, bitch, ovariohysterectomized, weighing 9.45 kg, was attended at the DermatologicalService of companion animals at the Veterinary Hospital of the Federal University of Jataí (UFJ). The animal came in withthe complaint of extensive dorsal alopecia, covered by firm lesions, with a 3-month evolution, additionally to polyuria andpolydipsia. After physical examination, alopecic areas of great extension were confirmed on the dorsum, on the internalsurface of the hind limbs and in the anal region. Also, an exudative and painful lesion located on the back was detected,plus loss of elasticity of the ventral abdomen skin and visible abdominal vessels. The screening tests showed a markedincrease in the alanine aminotransferase enzyme (ALT), alkaline phosphatase (ALP) and total cholesterol. The specificurinary density was decreased. On the ultrasound examination, hepatomegaly and an increase in the caudal pole of the leftadrenal were detected. Based on these findings, calcinosis cutis secondary to spontaneous hyperadrenocorticism (HAC)was suspected. For confirmation, skin biopsy and low dose dexamethasone suppression test (LDDS) were performed.LDDS test showed no reduction of serum cortisol after 8 h of dexamethasone dose administration and histopathological...(AU)

Diabetes insipidus central em felino jovem / Central diabetes insipidus in a young feline

Background: Central diabetes insipidus (CDI) is an endocrine disorder caused by the failure to produce, transport, orrelease ADH. This disease may show a primary etiology (idiopathic or congenital) or a secondary one (trauma or neoplasms). It is characterized by signs such as polyuria and polydipsia. The definitive diagnosis is obtained by the two-stepwater deprivation test; the absence of adequate urinary concentration in the first stage confirms the diagnosis of diabetesinsipidus and, in the second stage, the response to the application of synthetic desmopressin confirms a central origin.Because CDI is rare in felines, the aim of this study was to report the occurrence of a case of CDI, probably of congenitalprimary origin, in an 8-month-old kitten.Case: An 8-month-old male feline, castrated, 3.2 kg, was brought to consultation with a report of polydipsia, polyuria,smaller size and weight, and lower activity when compared to his brother, for several months. On physical examination,lethargy, body score 2/5, and mild dehydration were noted, as well as deciduous teeth that should have already been replaced. Abdominal ultrasound and laboratory tests were requested, which ruled out chronic kidney disease (CKD), diabetesmellitus (DM), hyperadrenocorticism (HAC), and hyperthyroidism. Due to the fact that urinalysis evidenced hyposthenuria(urinary density [UD] 1.004), CDI was suspected. The patient underwent a water deprivation test and, after 7.5 h, lost4.7% of his initial weight, while UD was 1.012, confirming the diagnosis of DI. The investigation then proceeded to theevaluation of the response to synthetic desmopressin by the application of 5 U IM. Two h later, UD was 1.019, confirming...

Evidence of pituitary hypoplasia associated with partial central diabetes insipidus in a young Persian cat

Background: Congenital anomalies are an uncommon pituitary hypofunction cause associated to multiple hormone deficiencies. Congenital hyposomatotropism is often related to an inherited anomaly, characterized mainly by delayed growth. It is not uncommon to find associated thyroid-stimulating hormone and gonadotropin deficiencies. Pituitary malformation may be associated to progressive cystic lesion expansion. Central diabetes insipidus (CDI) is another rare disease associated to polyuria (PU) and polydipsia (PD) secondary to antidiuretic hormone (ADH) deficient secretion. The aim of this report is to describe a likely case of pituitary hypoplasia, associated with partial CDI in a cat. Case: A 9-month-old unneutered male Persian cat weighing 2 kg was presented due to severe polyuria and polydipsia associated with growth deficit when compared with its sibling. After clinical and laboratory evaluations during the months in which the patient was monitored, reduced serum concentration of insulin-like growth factor-1 (IGF-1), thyroid-stimulating hormone (TSH), thyroid hormones, and testosterone were documented, confirming the diagnosis of hyposomatotropism, hypogonadism, and secondary hypothyroidism. Furthermore, therapeutic diagnosis with desmopressin revealed partial central diabetes insipidus (CDI). As the sibling showed normal development aging 13-months, a radiographic examination of the forelimb (carpus) was performed on both cats. There was lack of growth plate fusion in the patient, without any other evidence of dysgenesis, whereas complete epiphyseal closure was observed in the sibling. Despite therapeutic prescriptions of desmopressin and levothyroxine, the owners refused further follow-up to the...

Evidence of pituitary hypoplasia associated with partial central diabetes insipidus in a young Persian cat

Background: Congenital anomalies are an uncommon pituitary hypofunction cause associated to multiple hormone deficiencies. Congenital hyposomatotropism is often related to an inherited anomaly, characterized mainly by delayed growth. It is not uncommon to find associated thyroid-stimulating hormone and gonadotropin deficiencies. Pituitary malformation may be associated to progressive cystic lesion expansion. Central diabetes insipidus (CDI) is another rare disease associated to polyuria (PU) and polydipsia (PD) secondary to antidiuretic hormone (ADH) deficient secretion. The aim of this report is to describe a likely case of pituitary hypoplasia, associated with partial CDI in a cat. Case: A 9-month-old unneutered male Persian cat weighing 2 kg was presented due to severe polyuria and polydipsia associated with growth deficit when compared with its sibling. After clinical and laboratory evaluations during the months in which the patient was monitored, reduced serum concentration of insulin-like growth factor-1 (IGF-1), thyroid-stimulating hormone (TSH), thyroid hormones, and testosterone were documented, confirming the diagnosis of hyposomatotropism, hypogonadism, and secondary hypothyroidism. Furthermore, therapeutic diagnosis with desmopressin revealed partial central diabetes insipidus (CDI). As the sibling showed normal development aging 13-months, a radiographic examination of the forelimb (carpus) was performed on both cats. There was lack of growth plate fusion in the patient, without any other evidence of dysgenesis, whereas complete epiphyseal closure was observed in the sibling. Despite therapeutic prescriptions of desmopressin and levothyroxine, the owners refused further follow-up to the...(AU)

Diabetes insipidus central em felino jovem / Central diabetes insipidus in a young feline

Background: Central diabetes insipidus (CDI) is an endocrine disorder caused by the failure to produce, transport, orrelease ADH. This disease may show a primary etiology (idiopathic or congenital) or a secondary one (trauma or neoplasms). It is characterized by signs such as polyuria and polydipsia. The definitive diagnosis is obtained by the two-stepwater deprivation test; the absence of adequate urinary concentration in the first stage confirms the diagnosis of diabetesinsipidus and, in the second stage, the response to the application of synthetic desmopressin confirms a central origin.Because CDI is rare in felines, the aim of this study was to report the occurrence of a case of CDI, probably of congenitalprimary origin, in an 8-month-old kitten.Case: An 8-month-old male feline, castrated, 3.2 kg, was brought to consultation with a report of polydipsia, polyuria,smaller size and weight, and lower activity when compared to his brother, for several months. On physical examination,lethargy, body score 2/5, and mild dehydration were noted, as well as deciduous teeth that should have already been replaced. Abdominal ultrasound and laboratory tests were requested, which ruled out chronic kidney disease (CKD), diabetesmellitus (DM), hyperadrenocorticism (HAC), and hyperthyroidism. Due to the fact that urinalysis evidenced hyposthenuria(urinary density [UD] 1.004), CDI was suspected. The patient underwent a water deprivation test and, after 7.5 h, lost4.7% of his initial weight, while UD was 1.012, confirming the diagnosis of DI. The investigation then proceeded to theevaluation of the response to synthetic desmopressin by the application of 5 U IM. Two h later, UD was 1.019, confirming...(AU)

Central Diabetes insipidus in a cat

Background: Diabetes insipidus is a rare disease in cats with few reports in the scientifi c literature. It has two major forms: Central Diabetes Insipidus (CDI); characterized by decreased secretion of antidiuretic hormone (ADH), and Nephrogenic Diabetes Insipidus (NDI); characterized by decreased ability to concentrate urine because of resistance to ADH. The diagnosis is based on excluding diseases with polydipsia/polyuria, the water deprivation test and response to desmopressin. This case report describes Central Diabetes Insipidus in a domestic cat, as well as its response to desmopressin administered intranasally. Case: A 2-year old, male cat of non-defi ned breed and castrated was seen due to a history of polyuria and polydipsia (PU/ PD) that arose after allegedly ingesting thorns that got stuck to its body while going out of the house. Physical examination revealed an active well-fed animal with mild dehydration and persistent paradoxical ischuria. The complementary tests performed: abdominal ultrasound, blood test, urinalysis, serum urea, creatinine, glucose, cortisol, total T4, Total T3 and vasopressin, were within the reference values, except for urinary density and T4 that were below the standard. Based on the laboratory results, conditions compatible with PU and PD symptoms were excluded; however, despite normal vasopressin levels, diabetes insipidus was not ruled...(AU)

Central Diabetes insipidus in a cat

Background: Diabetes insipidus is a rare disease in cats with few reports in the scientifi c literature. It has two major forms: Central Diabetes Insipidus (CDI); characterized by decreased secretion of antidiuretic hormone (ADH), and Nephrogenic Diabetes Insipidus (NDI); characterized by decreased ability to concentrate urine because of resistance to ADH. The diagnosis is based on excluding diseases with polydipsia/polyuria, the water deprivation test and response to desmopressin. This case report describes Central Diabetes Insipidus in a domestic cat, as well as its response to desmopressin administered intranasally. Case: A 2-year old, male cat of non-defi ned breed and castrated was seen due to a history of polyuria and polydipsia (PU/ PD) that arose after allegedly ingesting thorns that got stuck to its body while going out of the house. Physical examination revealed an active well-fed animal with mild dehydration and persistent paradoxical ischuria. The complementary tests performed: abdominal ultrasound, blood test, urinalysis, serum urea, creatinine, glucose, cortisol, total T4, Total T3 and vasopressin, were within the reference values, except for urinary density and T4 that were below the standard. Based on the laboratory results, conditions compatible with PU and PD symptoms were excluded; however, despite normal vasopressin levels, diabetes insipidus was not ruled...