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Persistent SARS-CoV-2 antigen presence in multiple organs of a naturally infected cat from Brazil

Jarrah, Samar Afif; Kmetiuk, Louise Bach; Carvalho, Otávio Valério de; Sousa, Alessandra Tammy Hayakawa Ito de; Souza, Valeria Regia Franco; Nakazato, Luciano; Colodel, Edson Moleta; Santos, Andrea Pires dos; Pettan-Brewer, Christina; Hahn, Rosane Christine; Slhessarenko, Renata Dezengrini; Ubiali, Daniel Guimarães; Pereira, Asheley Henrique Barbosa; Morais, Helio Autran de; Biondo, Alexander Welker; Dutra, Valéria.
J. venom. anim. toxins incl. trop. dis; 28: e20210074, 2022. ilus
Artigo em Inglês | LILACS | ID: biblio-1365077


Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. Case presentation: We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen. Conclusion: The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.(AU)
Biblioteca responsável: BR68.1