Propolis anti-inflammatory effects on MAGE-1 and retinoic acid-treated dendritic cells and on Th1 and T regulatory cells
Santiago, Karina Basso; Conti, Bruno José; Cardoso, Eliza de Oliveira; Conte, Fernanda Lopes; Tasca, Karen Ingrid; Romagnoli, Graziela Gorete; Golim, Marjorie de Assis; Cruz, Maria Tereza; Sforcin, José Maurício.
J. venom. anim. toxins incl. trop. dis;
29: e20220044, 2023. tab, graf
Artigo
em Inglês
| VETINDEX
| ID: biblio-1418314
Resumo
Background: Propolis exhibits huge potential in the pharmaceutical industry. In the present study, its effects were investigated on dendritic cells (DCs) stimulated with a tumor antigen (MAGE-1) and retinoic acid (RA) and on T lymphocytes to observe a possible differential activation of T lymphocytes, driving preferentially to Th1 or Treg cells. Methods: Cell viability, lymphocyte proliferation, gene expression (T-bet and FoxP3), and cytokine production by DCs (TNF-α, IL-10, IL-6 and IL-1ß) and lymphocytes (IFN-γ and TGF-ß) were analyzed. Results: MAGE-1 and RA alone or in combination with propolis inhibited TNF-α production and induced a higher lymphoproliferation compared to control, while MAGE1 + propolis induced IL-6 production. Propolis in combination with RA induced FoxP3 expression. MAGE-1 induced IFN-γ production while propolis inhibited it, returning to basal levels. RA inhibited TGF-ß production, what was counteracted by propolis. Conclusion: Propolis affected immunological parameters inhibiting pro-inflammatory cytokines and favoring the regulatory profile, opening perspectives for the control of inflammatory conditions.(AU)
Biblioteca responsável:
BR68.1
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