Pimobendan improves clinical signs in short term compared to digoxin or placebo in dogs with heart failure due to chronic degenerative mitral valve disease
Larsson, Maria Helena Matiko Akao; Schwartz, Denise Saretta; Goldfeder, Guilherme Teixeira; Oliveira, Valéria Marinho Costa de; Itikawa, Paula Hiromi; Mazini, Ariane Marques; Melo, Priscylla Ramos Rosa; Machado, Fabrício Lorenzini Aranha; Lima Júnior, Francisco Ferreira; Kanayama, Khadine Kazue; Pellegrino, Arine; Daniel, Alexandre Gonçalves Teixeira; Ossada, Raul.
Acta sci. vet. (Impr.);
42: Pub.1175-Dec. 12, 2014. tab
Artigo
em Inglês
| VETINDEX
| ID: biblio-1457200
Resumo
Background: Chronic degenerative mitral valve disease (CDMVD) continues to be the most common cause of heart failure (HF) in small breed dogs. Pimobendan (PIMO) is a mixed action drug with inotropic and vasodilator properties and is widely used to treat heart disease in dogs. Therefore, PIMO increases cardiac output, reduces both preload and afterload and increases myocardial contractility without increasing energy consumption and myocardial oxygen. Digoxin (DIG) is a cardiac glycoside acting through inhibition of the sarcolemmal Na+/K+ ATPase pump, hence increasing intracellular calcium. It exerts beneficial effects on left ventricular function, symptoms and exercise tolerance. The purpose of this prospective, randomized, double blind clinical trial was to evaluate the clinical response and QoLQ in heart failure (HF) dogs treated with digoxin or pimobendan in addition to conventional therapy (furosemide and benazepril).Materials, Methods & Results: Inclusion criteria: dogs in class III or stabilized class IV (NYHA). Exclusion criteria: use of positive inotrope and antiarrhythmic, presence of atrial fibrillation, renal or hepatic disease or neoplasia. Thirty three dogs were included and randomly assigned to DIG (n = 11), PIMO (n = 14) and placebo (PL) (n = 8) and followed up weekly. Data was evaluated for days zero, 7, 14 and 28. Increasing score was assigned to...
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