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Clinical and pathological features of canine metastatic adrenocortical carcinoma

Silva, Elisângela Olegário da; Bracarense, Ana Paula Frederico Rodrigues Loureiro.
Acta Sci. vet.; 44(supl): 01-05, 2016. ilus
Artigo em Inglês | VETINDEX | ID: vti-15172

Resumo

Background: Adrenocortical carcinomas (ACC) are uncommon in dogs. ACC often invade the posterior vena cava wall and the advential layer of the abdominal aorta; however, metastases to distant organs are rare. Most dogs with ACC show clinical signs of Cushing`s syndrome in a similar way with signs reported in humans. The aim of this study is to report three cases of metastatic ACC in dogs and their clinical and pathological features. Cases: This report describes three cases of metastatic adrenocortical carcinoma (ACC) in dogs diagnosed post mortem through histopathological examination. The animals presented no signs of adrenal hormones overproduction. Case 1. A 13-year-old intact, mixed breed female dog was presented with a history of progressive hepatomegaly during the last four months. The animal was submitted to an exploratory laparotomy, but due to anesthetic complications no tissue specimen was sampled and after one week, the animal died. The necropsy examination showed an increased left adrenal (3 cm in diameter), multiple yellow to whitish nodules measuring 1 to 2 cm of diameter in the lung and severe hepatomegaly. The histopathological diagnosis was established as ACC with pulmonary metastasis. A severe and diffuse accumulation of glycogen in hepatocytes was also observed in Periodic acid-Schiff (PAS) staining. Case 2. A 9-year-old female intact, mixed breed dog was [...](AU)
Biblioteca responsável: BR68.1
Localização: BR68.1