Pulmonary oxidative stress in diabetic rats exposed to hyperoxia
Paiva, Letícia Alves; Silva, Iandara Schettert; Souza, Albert Schiaveto de; Cassino, Pedro Carvalho.
Acta cir. bras.;
32(7): 503-514, July 2017. ilus, tab
Artigo
em Inglês
| VETINDEX
| ID: vti-17591
Resumo
Purpose: To evaluate the pulmonary oxidative stress in diabetic rats exposed to hyperoxia for 90 minutes. Methods: Forty male Wistar rats were divided into four groups, each one containing 10 animals, according to the oxygen concentration to which they were exposed: 21%, 50%, 75% and 100% (hyperoxia). In each group five animals were randomly induced to diabetes by means of at a dose of 55 mg/kg of streptozotocin (STZ). Results: Seventy two hours after diabetes induction, a significant difference was seen in blood glucose in the experimental groups in comparison with the control. In the experimental groups a significant difference was observed in the concentration of malondialdehyde (MDA) in lung tissue and blood plasma (p 0.05), except the 50% group. In the control group, significant differences in the MDA concentration in plasma and lung tissue were also observed (p 0.05), except the 75% group. The MDA concentration in lung tissue in comparison with the diabetic and non-diabetic groups showed a significant difference in the 21% group; however, no difference was seen in the 75 and 100% groups. Conclusion: In diabetic animals high oxygen concentrations (75 and 100%) do not appear to exert deleterious effects on lipid peroxidation in lung tissue.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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