Effect of powdered shells treatment of the snail Megalobulimus lopesi on wounds of diabetic rats
Andrade, Paulo Henrique Muleta; Portugal, Luciane Canderolo; Rondon, Eric Schmidt; Kadri, Monica Cristina Toffoli; Matos, Maria de Fátima Cepa.
Acta cir. bras.;
33(2): 185-196, fev. 2018. tab, graf
Artigo
em Inglês
| VETINDEX
| ID: vti-18258
Resumo
Purpose: To analyzed the healing effect of the powdered shell of the Megalobulimus lopesi snail on wounds of diabetic rats, since in non-diabetic rats the powdered shell presented healing potential.Methods: Seventy-two Wistar rats (Rattus norvegicus albinus) were divided into three groups: Control group (GC.diab), no therapeutic intervention on the wound; Vehicles Control group, topical via, in diabetic rats (GCvt.diab): Powder Shell Group (PC) applied topically (GPCvt.diab): Experimental group was administered topically shortly after wound dressing and once a day during the experimental period (3, 7, 14 and 21 days) the composition containing the powdered shell of the snail. The following variables related to the healing potential were analyzed: macroscopic one, where the capacity of reduction of the wound area was evaluated; histological analysis in HE, angiogenic activity, morphometric analysis (re-epithelization), leukocyte inflammatory infiltrate; leukocyte count and also differentiation in peripheral blood.Results: The topical application in wounds of diabetic rats presented healing activity, accelerating wound closure, stimulating angiogenesis and being pro-inflammatory in the early and anti-inflammatory stages in the final times of the healing process.Conclusion: The topical administration of the powdered shell on wounds of diabetic patients becomes a therapeutic option of low cost, with ease in the administration and access as well.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
Texto completo