The positive effect of Botulinum toxin type A on the viability of random flap in tobacco exposed in rats
Camargo, Cristina Pires; Fernandes, Felipe Alexandre; Lee, Michel Hyo Mi; Silva, Luiza Campos Moreira; Besteiro, Julio Morais; Gemperli, Rolf.
Acta cir. bras.;
31(11): 720-723, Nov. 2016. ilus, tab
Artigo
em Inglês
| VETINDEX
| ID: vti-20919
Resumo
PURPOSE:To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure.METHODS:60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio.RESULTS:This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03).CONCLUSIONS:Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
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