Evaluation of the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice
Mota, Matheus Alves de Lima; Landim, José Saul Peixoto; Targino, Thiago Sousa Silva; Silva, Silvia Fernandes Ribeiro da; Silva, Sônia Leite da; Pereira, Márcio Roberto Pinho.
Acta cir. bras.;
30(4): 242-246, Apr. 2015. graf
Artigo
em Inglês
| VETINDEX
| ID: vti-22194
Resumo
PURPOSE: To evaluate the anti-inflammatory and analgesic effects of green tea (Camellia sinensis) in mice.METHODS:The anti-inflammatory effect of alcoholic extracts of green tea (AE) was evaluated in a cell migration assay with four groups of six Swiss mice receiving 0.07g/Kg or 0.14g/Kg EA (treatment groups), saline (negative control) or 10mg/Kg indomethacin (positive control) by gavage. One hour later 300 µg carrageen an was administered intraperitoneally or subcutaneously. The analgesic effect was evaluated using four groups of six animals receiving 0.07g/Kg or 0.14g/Kg EA, saline or 10mg/Kg indomethacin subcutaneously, followed 30 minutes later by 1% acetic acid.RESULTS: When administered subcutaneously at either dose (0.07g/Kg and 0.14g/Kg), AE inhibited carrageenan-induced cell migration (p 0.05). However, when administered by gavage, only the latter (0.14 g/Kg) was efficient (p 0.05). AE at both doses (0.07g/Kg and 0.14g/Kg) inhibited abdominal contortions (p 0.05), but the effect was not dose-dependent.CONCLUSION:Green tea was shown to have analgesic and anti-inflammatory properties and may constitute a natural treatment option in chronic inflammatory disorders.(AU)
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BR68.1
Localização: BR68.1
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