New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
Macêdo, Clóvis Ney Pinheiro; Braga, Francisco Evanilso Silva; Campelo, Ana Paula Bomfim Soares; Diniz, Gabriel Maia; Lopes, Luiz Gonzaga de França; Kubrusly, Marcos; Campelo, Marcio Wilker Soares.
Acta cir. bras.;
34(12): e201901201, 2019. ilus
Artigo
em Inglês
| VETINDEX
| ID: vti-24496
Resumo
Purpose To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Methods Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. Results At the histological examination, all animals (six animals 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). Conclusion Rut-bpy may prevent renal histological changes in rats caused by meloxicam.(AU)
Biblioteca responsável:
BR68.1
Localização: BR68.1
Texto completo